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ChemicalBook >> CAS DataBase List >>3-iodo-1H-pyrrolo[3,2-b]pyridine

3-iodo-1H-pyrrolo[3,2-b]pyridine

3-iodo-1H-pyrrolo[3,2-b]pyridine Structure
3-iodo-1H-pyrrolo[3,2-b]pyridine structure
CAS No.
1083181-26-3
Chemical Name:
3-iodo-1H-pyrrolo[3,2-b]pyridine
Synonyms
3-Iodo-4-azaindole;3-iodo-1H-pyrrolo[3,2-b]pyridine;1H-Pyrrolo[3,2-b]pyridine, 3-iodo-
CBNumber:
CB71515784
Molecular Formula:
C7H5IN2
Molecular Weight:
244.03
MDL Number:
MFCD11559019
MOL File:
1083181-26-3.mol
MSDS File:
SDS
Last updated:2026-05-28 02:51:08
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3-iodo-1H-pyrrolo[3,2-b]pyridine Properties

Boiling point 360.7±22.0 °C(Predicted)
Density 2.082
storage temp. 2-8°C(protect from light)
pka 13.16±0.40(Predicted)
Appearance White to off-white Solid
InChI InChI=1S/C7H5IN2/c8-5-4-10-6-2-1-3-9-7(5)6/h1-4,10H
InChIKey ZLVQSDNBINQPHB-UHFFFAOYSA-N
SMILES C12C(I)=CNC1=CC=CN=2

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H319-H335-H302+H312+H332-H315
Precautionary statements  P301+P312-P302+P352-P305+P351+P338
HS Code  2933998090

3-iodo-1H-pyrrolo[3,2-b]pyridine price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR321324 3-Iodo-1H-pyrrolo[3,2-b]pyridine 97% 1083181-26-3 250mg $21 2026-06-04 Buy
Activate Scientific AS39384 3-Iodo-1H-pyrrolo[3,2-b]pyridine 98% 1083181-26-3 1g $50 2026-06-04 Buy
Apolloscientific OR321324 3-Iodo-1H-pyrrolo[3,2-b]pyridine 97% 1083181-26-3 1g $48 2026-06-04 Buy
Activate Scientific AS39384 3-Iodo-1H-pyrrolo[3,2-b]pyridine 98% 1083181-26-3 5g $139 2026-06-04 Buy
Synthonix K44806 3-Iodo-1H-pyrrolo[3,2-b]pyridine 98% 1083181-26-3 100mg $24 2026-05-06 Buy
Product number Packaging Price Buy
OR321324 250mg $21 Buy
AS39384 1g $50 Buy
OR321324 1g $48 Buy
AS39384 5g $139 Buy
K44806 100mg $24 Buy

3-iodo-1H-pyrrolo[3,2-b]pyridine Chemical Properties, Uses, Production

Uses

3-Iodo-1H-pyrrolo[3,2-B]pyridine is a pyridine derivative that can be used to prepare plasma kallikrein inhibitors.

Synthesis

4-Azaindole

272-49-1

3-iodo-1H-pyrrolo[3,2-b]pyridine

1083181-26-3

1H-pyrrolo[3,2-b]pyridine (1.94 g, 16.4 mmol) was used as starting material and dissolved in tetrahydrofuran (THF, 10 mL). Subsequently, N-iodosuccinimide (NIS, 4.06 g, 18.1 mmol) was added to this solution. The reaction mixture was stirred at room temperature overnight, during which precipitation was observed to be generated. Upon completion of the reaction, the precipitate was collected by filtration and washed sequentially with a small amount of THF and heptane. The resulting white solid was dried under vacuum to afford the target product 3-iodo-1H-pyrrolo[3,2-b]pyridine (4.1 g, quantitative yield). The structure of the product was confirmed by 1H NMR (DMSO-d6, 300 MHz) δ 8.40 (s, 1H), 7.90-7.70 (m, 2H), 7.15 (d, 1H) and LC-MS (retention time 0.41 min; m/z 245 [M+1]+).

References

[1] Patent: WO2011/78984, 2011, A1. Location in patent: Page/Page column 72
[2] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 24, p. 6935 - 6938
[3] Patent: WO2018/11628, 2018, A1. Location in patent: Paragraph 00203
[4] Organic and Biomolecular Chemistry, 2011, vol. 9, # 14, p. 5129 - 5136
[5] Patent: US2015/94328, 2015, A1. Location in patent: Paragraph 0349; 0350-0352

3-iodo-1H-pyrrolo[3,2-b]pyridine Preparation Products And Raw materials

Raw materials

4-Azaindole Tetrahydrofuran N-Iodosuccinimide

Preparation Products

3-iodo-1H-pyrrolo[3,2-b]pyridine Suppliers

Global Suppliers ( 87)
Supplier Tel Email Country ProdList Advantage
Tianjin Ruide Famo Technology Co., Ltd 13821803402 RD_PHARM@163.com China 842 58
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Shijiazhuang suchen Chemical Technology Co. LTD 186-33933494 18032288352 1130239@qq.com China 192 60
SuZhou ShiYa Biopharmaceuticals, Inc. 86(512)5235 8471 17715136450 sales@shiyabiopharm.com China 4167 58
The future of Shanghai Industrial Co., Ltd. 021-61552785 sales@shshiji.com China 9531 55
SynAsst Chemical. 021-60343070 China 12731 55
Supplier Advantage
Tianjin Ruide Famo Technology Co., Ltd 58
Beijing Ouhe Technology Co., Ltd 60
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Jia Xing Isenchem Co.,Ltd 66
Pure Chemistry Scientific Inc. 62
Adamas Reagent, Ltd. 59
Shijiazhuang suchen Chemical Technology Co. LTD 60
SuZhou ShiYa Biopharmaceuticals, Inc. 58
The future of Shanghai Industrial Co., Ltd. 55
SynAsst Chemical. 55

3-iodo-1H-pyrrolo[3,2-b]pyridine Spectrum

3-iodo-1H-pyrrolo[3,2-b]pyridine(1083181-26-3)1HNMR
3-iodo-1H-pyrrolo[3,2-b]pyridine 3-Iodo-4-azaindole 1H-Pyrrolo[3,2-b]pyridine, 3-iodo- 1083181-26-3