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Methyl 1-benzyl-3-oxopiperidine-4-carboxylate

CAS No.
175406-94-7
Chemical Name:
Methyl 1-benzyl-3-oxopiperidine-4-carboxylate
Synonyms
Methyl 1-benzyl-3-oxo-4-piperidinecarboxylate;Methyl 1-benzyl-3-oxopiperidine-4-carboxylate;methyl 1-benzyl-3-oxohexahydropyridine-4-carboxylate;Methyl 3-oxo-1-(phenylmethyl)-4-piperidinecarboxylate;4-Piperidinecarboxylic acid, 3-oxo-1-(phenylmethyl)-, methyl ester
CBNumber:
CB71522933
Molecular Formula:
C14H17NO3
Molecular Weight:
247.29
MDL Number:
MFCD00012792
MOL File:
175406-94-7.mol
MSDS File:
SDS
Last updated:2026-05-28 03:01:30

Methyl 1-benzyl-3-oxopiperidine-4-carboxylate Properties

Boiling point 354.4±42.0 °C(Predicted)
Density 1.177±0.06 g/cm3(Predicted)
pka 10.83±0.20(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P280-P305+P351+P338

Methyl 1-benzyl-3-oxopiperidine-4-carboxylate price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ACHEMBLOCK X192492 Methyl 1-Benzyl-3-oxopiperidine-4-carboxylate 95.00% 175406-94-7 250MG $205 2026-05-27 Buy
ACHEMBLOCK X192492 Methyl 1-Benzyl-3-oxopiperidine-4-carboxylate 95.00% 175406-94-7 1G $620 2026-05-27 Buy
ACHEMBLOCK X192492 Methyl 1-Benzyl-3-oxopiperidine-4-carboxylate 95.00% 175406-94-7 5G $1610 2026-05-27 Buy
Crysdot CD11231725 Methyl 1-benzyl-3-oxopiperidine-4-carboxylate 95+% 175406-94-7 250mg $79 2026-05-26 Buy
Crysdot CD11231725 Methyl 1-benzyl-3-oxopiperidine-4-carboxylate 95+% 175406-94-7 1g $240 2026-05-26 Buy
Product number Packaging Price Buy
X192492 250MG $205 Buy
X192492 1G $620 Buy
X192492 5G $1610 Buy
CD11231725 250mg $79 Buy
CD11231725 1g $240 Buy

Methyl 1-benzyl-3-oxopiperidine-4-carboxylate Chemical Properties, Uses, Production

Synthesis

1-Benzyl-3-piperidone

40114-49-6

Dimethyl carbonate

616-38-6

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

175406-94-7

To a stirred mixture of 1-benzyl-3-piperidone (72 g) and dimethyl carbonate (500 mL) was added sodium hydride (38 g, 60% oil dispersion) in batches. The reaction mixture was heated to reflux for 20 min and then the reaction was quenched by the slow addition of water (800 mL). The aqueous phase was extracted with ethyl acetate (3 x 400 mL), the organic phases were combined and dried over anhydrous sodium sulfate. The organic phase was concentrated under reduced pressure to give methyl 1-benzyl-3-oxopiperidine-4-carboxylate as a brown oil (93 g, 99% yield). lc-MS (ESI+): m/z 248 [M+H]+.

References

[1] Patent: WO2009/26241, 2009, A1. Location in patent: Page/Page column 77-78

40114-49-6
616-38-6
175406-94-7
Synthesis of Methyl 1-benzyl-3-oxopiperidine-4-carboxylate from 1-Benzyl-3-piperidone and Dimethyl carbonate

Methyl 1-benzyl-3-oxopiperidine-4-carboxylate Preparation Products And Raw materials

Methyl 1-benzyl-3-oxopiperidine-4-carboxylate Suppliers

Global Suppliers ( 38)
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Methyl 1-benzyl-3-oxopiperidine-4-carboxylate Methyl 1-benzyl-3-oxo-4-piperidinecarboxylate 4-Piperidinecarboxylic acid, 3-oxo-1-(phenylmethyl)-, methyl ester Methyl 3-oxo-1-(phenylmethyl)-4-piperidinecarboxylate methyl 1-benzyl-3-oxohexahydropyridine-4-carboxylate 175406-94-7