Heptanoyl-Coenzyme A (sodium salt)
- CAS No.
- Chemical Name:
- Heptanoyl-Coenzyme A (sodium salt)
- Synonyms
- Heptanoyl-Coenzyme A (sodium salt)
- CBNumber:
- CB715499197
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
Heptanoyl-Coenzyme A (sodium salt) Chemical Properties, Uses, Production
Description
Heptanoyl-coenzyme A (heptanoyl-CoA) is a derivative of CoA (Item Nos. 16147 | 21499 | 21722) that contains the medium-chain fatty acid heptanoic acid (Item No. 33672).1 It inhibits butyryl-CoA:acetate-CoA transferase isolated from the gut bacteria P. elsdenii when used at a concentration of 200 µM. Heptanoyl-CoA levels are increased in primary fibroblasts derived from patients with medium-chain acyl-CoA dehydrogenase (MCAD) deficiency in the presence of heptanoic acid, indicating heptanoyl-CoA formation by short-chain acyl-transferases.2 It blocks decreases in infarct volume and improvements in motor function induced by the isoquinoline alkaloid berberine (Item No. 10006427) in a mouse model of ischemic stroke induced by middle cerebral artery occlusion (MCAO) when administered at a dose of 0.4 mg/kg per day.3WARNING This product is not for human or veterinary use.
References
[1] M SCHULMAN D V. Kinetics and catalytic properties of coenzyme A transferase from Peptostreptococcus elsdenii.[J]. Journal of Bacteriology, 1976, 128 1: 372-381. DOI: 10.1128/jb.128.1.372-381.1976
[2] ANURADHA KARUNANIDHI . Heptanoic and medium branched-chain fatty acids as anaplerotic treatment for medium chain acyl-CoA dehydrogenase deficiency[J]. Molecular genetics and metabolism, 2023, 140 3: Article 107689. DOI: 10.1016/j.ymgme.2023.107689
[3] DUAN H, HU J, DENG Y, et al. Berberine Mediates the Production of Butyrate to Ameliorate Cerebral Ischemia via Gut Microbiota in Mice[C]//17 1. 2023: 0. DOI: 10.20944/preprints202310.1351.v1
Heptanoyl-Coenzyme A (sodium salt) Preparation Products And Raw materials
Raw materials
Preparation Products
Heptanoyl-Coenzyme A (sodium salt) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Beiwanta Biotechnology Co., Ltd. | 021-67187366 19901745723 | info@bwtlab.com | China | 9888 | 58 |
| Shanghai meikai technology co., ltd | 021-68689288 15300790979 | info@mkbio.com.cn | China | 9988 | 58 |
| Supplier | Advantage |
|---|---|
| Shanghai Beiwanta Biotechnology Co., Ltd. | 58 |
| Shanghai meikai technology co., ltd | 58 |
