ChemicalBook >> CAS DataBase List >>5-CHLORO-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID

5-CHLORO-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID

CAS No.
128455-63-0
Chemical Name:
5-CHLORO-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID
Synonyms
BUTTPARK 99\18-36;RARECHEM AL BO 1764;5-Chloro-1-methyl-3-(trifluoromethyl);4-Carboxy-5-chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazole;5-chloro-1-methyl-3-trifluoromethylpyrazole-4-carboxylic acid;5-chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxyl...;5-CHLORO-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID;1H-Pyrazole-4-carboxylic acid, 5-chloro-1-methyl-3-(trifluoromethyl)-;5-Chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylicacid97%
CBNumber:
CB7155068
Molecular Formula:
C6H4ClF3N2O2
Molecular Weight:
228.56
MDL Number:
MFCD00215443
MOL File:
128455-63-0.mol
MSDS File:
SDS
Last updated:2026-05-28 03:15:23
Product description Number Pack Size Price
5-Chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid ≥95% PC6318 250mg $21
5-Chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid ≥95% PC6318 1g $37
5-Chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid ≥95% PC6318 250mg $21
5-Chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid ≥95% PC6318 1g $37
5-Chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid 043794 500.00mg $486
More product size

5-CHLORO-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID Properties

Melting point 201 °C
Boiling point 284.4±40.0 °C(Predicted)
Density 1.71±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka 1.77±0.50(Predicted)
CAS DataBase Reference 128455-63-0(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xi,Xn
Risk Statements  20/21/22-36/37/38
Safety Statements  26
HazardClass  IRRITANT
HS Code  2933199090

5-CHLORO-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID price More Price(48)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific PC6318 5-Chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid ≥95% 128455-63-0 250mg $21 2026-06-04 Buy
Apolloscientific PC6318 5-Chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid ≥95% 128455-63-0 1g $37 2026-06-04 Buy
Apolloscientific PC6318 5-Chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid ≥95% 128455-63-0 250mg $21 2026-06-04 Buy
Apolloscientific PC6318 5-Chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid ≥95% 128455-63-0 1g $37 2026-06-04 Buy
Matrix Scientific 043794 5-Chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid 128455-63-0 500.00mg $486 2026-05-18 Buy
Product number Packaging Price Buy
PC6318 250mg $21 Buy
PC6318 1g $37 Buy
PC6318 250mg $21 Buy
PC6318 1g $37 Buy
043794 500.00mg $486 Buy

5-CHLORO-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID Chemical Properties,Uses,Production

Synthesis

5-CHLORO-1-METHYL-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXALDEHYDE

128455-62-9

5-CHLORO-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID

128455-63-0

Example 5: 10 g of 5-chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxaldehyde was added to 50 mL of an aqueous solution containing 5 g of sodium hydroxide (2 equivalents). Under vigorous stirring, 34.4 g of 35% hydrogen peroxide solution was slowly added in 8 drops over a temperature range of 40°C to 50°C, taking 1.5 hours. After the dropwise addition was completed, the reaction mixture was continued to be stirred for 30 minutes and subsequently cooled to 15°C. The pH of the reaction solution was adjusted to 1 with concentrated hydrochloric acid and the solid product was precipitated. The crystals were collected by filtration and washed well with water, after which the crystals were dissolved in ether. The ether solution was dried over anhydrous magnesium sulfate and decolorized by activated carbon, and then the ether was removed by distillation under reduced pressure to give 8.6 g of 5-chloro-1-methyl-3-(trifluoromethyl)pyrrole-4-carboxylic acid in 80.0% yield and 197.5-199.5 °C melting point.

References

[1] Patent: US2004/19221, 2004, A1. Location in patent: Page 7
[2] Patent: CN103951663, 2016, B. Location in patent: Paragraph 0091; 0096; 0097
[3] Journal of Heterocyclic Chemistry, 1990, vol. 27, # 2, p. 243 - 245
[4] Patent: WO2007/84868, 2007, A2. Location in patent: Page/Page column 39
[5] Journal of Heterocyclic Chemistry, 2011, vol. 48, # 2, p. 389 - 396

5-CHLORO-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID Preparation Products And Raw materials

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View Lastest Price from 5-CHLORO-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
5-CHLORO-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID pictures 2019-07-06 5-CHLORO-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID
128455-63-0
$100.00 1KG 98% 100KG Career Henan Chemical Co
5-Chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylicacid97% 5-Chloro-1-methyl-3-(trifluoromethyl) BUTTPARK 99\18-36 5-CHLORO-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID RARECHEM AL BO 1764 4-Carboxy-5-chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazole 5-chloro-1-methyl-3-trifluoromethylpyrazole-4-carboxylic acid 1H-Pyrazole-4-carboxylic acid, 5-chloro-1-methyl-3-(trifluoromethyl)- 5-chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxyl... 128455-63-0 C6H4ClF3N2O2 C6H3ClF3N2O2 Carboxylic Acids Pyrazoles & Triazoles Heterocyclic Building Blocks New Products for Chemical Synthesis Pyrazoles Building Blocks Pyrazole Chemical Synthesis Carboxylic Acids Pyrazoles & Triazoles C6