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(4-Trifluoromethyl-pyridin-3-yl)-methanol

(4-Trifluoromethyl-pyridin-3-yl)-methanol Structure
(4-Trifluoromethyl-pyridin-3-yl)-methanol structure
CAS No.
198401-76-2
Chemical Name:
(4-Trifluoromethyl-pyridin-3-yl)-methanol
Synonyms
4-(Trifluoromethyl)-3-pyridinemethanol;3-Pyridinemethanol, 4-(trifluoromethyl)-;(4-Trifluoromethyl-pyridin-3-yl)-methanol
CBNumber:
CB71554077
Molecular Formula:
C7H6F3NO
Molecular Weight:
177.12
MDL Number:
MFCD10568162
MOL File:
198401-76-2.mol
MSDS File:
SDS
Last updated:2026-05-28 03:15:29
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(4-Trifluoromethyl-pyridin-3-yl)-methanol Properties

storage temp. Sealed in dry,Room Temperature
Appearance Colorless to light yellow Liquid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338

(4-Trifluoromethyl-pyridin-3-yl)-methanol price More Price(39)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Activate Scientific AS45187 3-(Hydroxymethyl)-4-(trifluoromethyl)pyridine 95% 198401-76-2 1g $518 2026-06-04 Buy
aablocks AA002BEV (4-(Trifluoromethyl)Pyridin-3-Yl)Methanol 98% 198401-76-2 100mg $67 2026-05-28 Buy
aablocks AA002BEV (4-(Trifluoromethyl)Pyridin-3-Yl)Methanol 98% 198401-76-2 250mg $110 2026-05-28 Buy
aablocks AA002BEV (4-(Trifluoromethyl)Pyridin-3-Yl)Methanol 95% 198401-76-2 1g $352 2026-05-28 Buy
aablocks AA002BEV (4-(Trifluoromethyl)Pyridin-3-Yl)Methanol 95% 198401-76-2 5g $952 2026-05-28 Buy
Product number Packaging Price Buy
AS45187 1g $518 Buy
AA002BEV 100mg $67 Buy
AA002BEV 250mg $110 Buy
AA002BEV 1g $352 Buy
AA002BEV 5g $952 Buy

(4-Trifluoromethyl-pyridin-3-yl)-methanol Chemical Properties, Uses, Production

Synthesis

METHYL 4-(TRIFLUOROMETHYL)NICOTINATE

175204-82-7

(4-Trifluoromethyl-pyridin-3-yl)-methanol

198401-76-2

General procedure for the synthesis of (4-trifluoromethyl-3-pyridine)-methanol from 4-trifluoromethylnicotinic acid methyl ester: 0.37 g (9.7 mmol) of lithium aluminum hydride was dissolved in 100 ml of THF and the solution was cooled down to -50 °C. Subsequently, a solution of 2.0 g (9.8 mmol) of methyl 4-trifluoromethylnicotinate dissolved in 30 ml of THF was added slowly and dropwise. The reaction mixture was stirred continuously at -50 °C for 3 h to ensure complete reaction. Upon completion of the reaction, ethyl acetate was added cautiously and stirred briefly before adding water and continuing to stir. The reaction mixture was separated by vacuum filtration and the filtrate was extracted with ethyl acetate. The organic layer obtained by extraction was washed sequentially with water and aqueous sodium chloride solution and subsequently dried with anhydrous magnesium sulfate. The dried solution was distilled under vacuum to remove the solvent, and the residue was purified by silica gel column chromatography (unfolding agent: hexane-ethyl acetate mixed solvent) to finally obtain 0.6 g (35.3% yield) of (4-trifluoromethylpyridin-3-yl)-methanol as a yellow oil. The product was analyzed by 1H-NMR [CDCl3/TMS, δ (ppm)]: 9.00 (1H, s), 8.73 (1H, d), 7.51 (1H, d), 4.95 (2H, s).

References

[1] Patent: EP1364946, 2003, A1. Location in patent: Page/Page column 200-201
[2] Patent: US2005/256004, 2005, A1. Location in patent: Page/Page column 35
[3] Patent: US5756497, 1998, A

(4-Trifluoromethyl-pyridin-3-yl)-methanol Preparation Products And Raw materials

Raw materials

Methyl 4-(trifluoromethyl)nicotinate Tetrahydrofuran Lithium Aluminum Hydride

Preparation Products

(4-Trifluoromethyl-pyridin-3-yl)-methanol Suppliers

Global Suppliers ( 47)
Supplier Tel Email Country ProdList Advantage
SynAsst Chemical. 021-60343070 China 12731 55
Aloespharm Co., Ltd. 021-20960837 market@aloespharm.com China 1299 55
Cochemical Ltd. 029-86115547 17791676824 sales@cochemical.com China 3014 58
ShangHai AmK Pharmaceutical Technology Co., Ltd. 微信 18019252918 18019252918 sale@amkchem.com China 14982 55
Shanghai HuanChuan Industry Co.,Ltd. 021-61478794 sales@hcshhai.com China 9781 50
JW & Y Pharmlab Co., Ltd. 021-64340559 xinyu_shi@jwypharmlab.com.cn China 11999 58
SuZhou ShiYa Biopharmaceuticals, Inc. 0512-0512-52358471 17715136450 sales@shiyabiopharm.com China 9814 58
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Nanijing m&m biotechnology Co. ,Ltd. 025-87782433 18021532344 1345332203@qq.com China 4226 58
Sichuan BoYou Biotechnology Co., Ltd. 028-65791793 18140026355 568470422@qq.com China 9961 58
Supplier Advantage
SynAsst Chemical. 55
Aloespharm Co., Ltd. 55
Cochemical Ltd. 58
ShangHai AmK Pharmaceutical Technology Co., Ltd. 55
Shanghai HuanChuan Industry Co.,Ltd. 50
JW & Y Pharmlab Co., Ltd. 58
SuZhou ShiYa Biopharmaceuticals, Inc. 58
Amadis Chemical Company Limited 58
Nanijing m&m biotechnology Co. ,Ltd. 58
Sichuan BoYou Biotechnology Co., Ltd. 58

(4-Trifluoromethyl-pyridin-3-yl)-methanol Spectrum

(4-Trifluoromethyl-pyridin-3-yl)-methanol(198401-76-2)1HNMR

198401-76-2 ((4-Trifluoromethyl-pyridin-3-yl)-methanol) Related Search:

4-(Trifluoromethyl)nicotinic acid Methyl 6-chloro-4-(trifluoromethyl)nicotinate 2-Methyl-4-trifluoromethyl-nicotinic acid 2,6-Dichloro-4-trifluoromethyl-nicotinic acid RARECHEM AL BO 2173
Methyl 4-(trifluoromethyl)nicotinate 6-Hydroxy-4-(trifluoromethyl)nicotinicacid 6-[(Quinolin-8-yl)oxy]-4-(trifluoromethyl)pyridine-3-carboxylic acid, methyl ester RARECHEM AL BO 2071 RARECHEM AL BO 1640
RARECHEM AL BO 0986 RARECHEM AL BO 0931 RARECHEM AL BO 0988 RARECHEM AL BW 1946 RARECHEM AL BO 1641
RARECHEM AL BO 2132 RARECHEM AL BO 2072 4-(Cyanomethyl)phenyl 2-chloro-4-(trifluoromethyl)nicotinate

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(4-Trifluoromethyl-pyridin-3-yl)-methanol 3-Pyridinemethanol, 4-(trifluoromethyl)- 4-(Trifluoromethyl)-3-pyridinemethanol 198401-76-2