BOC-(4-AMINOPHENYL)ACETIC ACID
- CAS No.
- 81196-09-0
- Chemical Name:
- BOC-(4-AMINOPHENYL)ACETIC ACID
- Synonyms
- BOC-4-APH-OH;BOC-APH(4)-OH;BOC-4-APAC-OH;BOC-4-NHPHAC-OH;BOC-(4-AMINOPHENYL)ACETIC ACID;4-(Boc-aMino)phenylacetic acid;4-(T-Butoxycarbonylamino)phenylacetic acid;4-(T-BUTYLOXYCARBONYLAMINO)PHENYLACETIC ACID;4-(tert-Butoxycarbonylamino)benzeneacetic acid;4-(TERT-BUTYLOXYCARBONYLAMINO)-PHENYLACETIC ACID
- CBNumber:
- CB7155482
- Molecular Formula:
- C13H17NO4
- Molecular Weight:
- 251.28
- MDL Number:
- MFCD00099367
- MOL File:
- 81196-09-0.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H315-H335 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
| HazardClass | IRRITANT |
| HS Code | 29225090 |
BOC-(4-AMINOPHENYL)ACETIC ACID price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 265374 | Boc-4-aminophenylacetic acid | 81196-09-0 | 1g | $366 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB49969 | Boc-4-aminophenylacetic acid | 81196-09-0 | 10g | $393.3 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 38329 | 2-(4-((tert-Butoxycarbonyl)amino)phenyl)aceticacid 95+% | 81196-09-0 | 5G | $460 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0091721 | BOC-(4-AMINOPHENYL)ACETIC ACID 95.00% | 81196-09-0 | 1G | $721.57 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0091721 | BOC-(4-AMINOPHENYL)ACETIC ACID 95.00% | 81196-09-0 | 2.5G | $983.88 | 2021-12-16 | Buy |
BOC-(4-AMINOPHENYL)ACETIC ACID Chemical Properties,Uses,Production
Chemical Properties
White crystalline powder
Synthesis
24424-99-5
1197-55-3
81196-09-0
General method: synthesis of 2-(4-((tert-butoxycarbonyl)amino)phenyl)acetic acid (5). 4-Aminophenylacetic acid (4, 4 g, 26.46 mmol, 1 equiv) was dissolved in a solvent mixture of dioxane (52 mL) and water (52 mL). In a separate vessel, sodium carbonate (2.8 g, 26.42 mmol, 1 eq.) was dissolved in water (25 mL), stirred and cooled in an ice bath. The sodium carbonate solution was added to a solution of 4-aminophenylacetic acid followed by a one-time addition of di-tert-butyl dicarbonate (BOC-anhydride, 6.24 g, 28.59 mmol, 1.1 eq.). The reaction mixture was continued to be stirred at room temperature for 4 hours. After completion of the reaction, the dioxane was removed by distillation under reduced pressure. The cooled aqueous layer was covered with ethyl acetate and acidified with dilute KHSO4 solution to pH 4. Subsequent extraction with ethyl acetate was carried out and the organic layers were combined and purified by column chromatography (eluent ratio of ethyl acetate-hexane-acetic acid in 1:1:1 eluent ratio) to afford the target compound 5 (7.07 g, 94% yield) as a white solid.1H-NMR (300 MHz, CDCl3) The data were as follows: δ 7.29 (d, J = 8.40 Hz, 2H), 7.19 (d, J = 8.47 Hz, 2H), 3.70 (s, 1H), 3.58 (s, 2H), 1.52 (s, 9H).
References
[1] Journal of Medicinal Chemistry, 1998, vol. 41, # 13, p. 2361 - 2370
[2] Molecules, 2017, vol. 22, # 1,
[3] Patent: US6335445, 2002, B1. Location in patent: Page column 86-87
[4] Journal of Medicinal Chemistry, 2013, vol. 56, # 1, p. 254 - 263
[5] Patent: WO2014/85545, 2014, A1. Location in patent: Page/Page column 52; 53
BOC-(4-AMINOPHENYL)ACETIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30229 | 58 |
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; +8619817745290 | bd@blocksynth.com | China | 5661 | 58 |
| Golden Pharma Co., Limited | +undefined18958062155 | sales@zjgoldpharm.com | China | 5899 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Sichuan Biosynce Pharmatech Co., Ltd. | +8619950309693 | diane@biosynce.com | China | 4871 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 |
View Lastest Price from BOC-(4-AMINOPHENYL)ACETIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-01-15 | Boc-4-aminophenylaceticacid
81196-09-0
|
US $0.00 / KG | 1KG | 97.0% | 100 tons | Honest Joy Holdings Limited |
-
- Boc-4-aminophenylaceticacid
81196-09-0
- US $0.00 / KG
- 97.0%
- Honest Joy Holdings Limited
81196-09-0(BOC-(4-AMINOPHENYL)ACETIC ACID)Related Search:
1of3
