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1,2,3-Trifluoro-4-nitrobenzene

1,2,3-Trifluoro-4-nitrobenzene Structure
1,2,3-Trifluoro-4-nitrobenzene structure
CAS No.
771-69-7
Chemical Name:
1,2,3-Trifluoro-4-nitrobenzene
Synonyms
2,3,4-TRIFLUORONITROBENZENE;1,2,3-Trifluoro-4-ni;4-chloro-2-fluroaniline;4-Trifluoronitrobenzene;2,3,4-Trifluornitrobenzene;3,4,5 TRIFLUORONITROBENZEN;2,3,4-TRIFLUORONITROBRNZENE;1,2,3-Trifluor-4-nitrobenzol;2,3-Trifluoro-4-nitrobenzene;1,2,3-Trifluoro-4-nitrobenzen
CBNumber:
CB7155826
Molecular Formula:
C6H2F3NO2
Molecular Weight:
177.08
MDL Number:
MFCD00041546
MOL File:
771-69-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 03:19:17
Product description Number Pack Size Price
2,3,4-Trifluoronitrobenzene 99% 338362 25g $29
2,3,4-Trifluoronitrobenzene >98.0%(GC) T1539 5g $25
2,3,4-Trifluoronitrobenzene >98.0%(GC) T1539 25g $63
2,3,4-Trifluoronitrobenzene FT36934 100g $150
2,3,4-Trifluoronitrobenzene FT36934 50g $150
More product size
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1,2,3-Trifluoro-4-nitrobenzene Properties

Boiling point 92 °C/20 mmHg (lit.)
Density 1.541 g/mL at 25 °C (lit.)
refractive index n20/D 1.492(lit.)
Flash point 200 °F
storage temp. Sealed in dry,Room Temperature
form clear liquid
Specific Gravity 1.541
color Light yellow to Yellow to Orange
BRN 2449746
InChI InChI=1S/C6H2F3NO2/c7-3-1-2-4(10(11)12)6(9)5(3)8/h1-2H
InChIKey ARCACZWMYGILNI-UHFFFAOYSA-N
SMILES C1(F)=CC=C([N+]([O-])=O)C(F)=C1F
CAS DataBase Reference 771-69-7(CAS DataBase Reference)
FDA UNII NKN86LZ8MM
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338
target organs Respiratory system
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xn,Xi
Risk Statements  20/21/22-36/37/38
Safety Statements  26-36/37/39-24/25
RIDADR  UN2810
WGK Germany  3
Hazard Note  Irritant
HazardClass  6.1
PackingGroup  III
HS Code  29042090
Storage Class 10 - Combustible liquids
Hazard Classifications Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
2
2 0

1,2,3-Trifluoro-4-nitrobenzene price More Price(75)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 338362 2,3,4-Trifluoronitrobenzene 99% 771-69-7 25g $29 2023-06-20 Buy
TCI Chemical T1539 2,3,4-Trifluoronitrobenzene >98.0%(GC) 771-69-7 5g $25 2026-04-30 Buy
TCI Chemical T1539 2,3,4-Trifluoronitrobenzene >98.0%(GC) 771-69-7 25g $63 2026-04-30 Buy
Biosynth FT36934 2,3,4-Trifluoronitrobenzene 771-69-7 100g $150 2026-06-04 Buy
Biosynth FT36934 2,3,4-Trifluoronitrobenzene 771-69-7 50g $150 2026-06-04 Buy
Product number Packaging Price Buy
338362 25g $29 Buy
T1539 5g $25 Buy
T1539 25g $63 Buy
FT36934 100g $150 Buy
FT36934 50g $150 Buy

1,2,3-Trifluoro-4-nitrobenzene Chemical Properties,Uses,Production

Uses

2,3,4-Trifluoronitrobenzene is a useful research chemical.

Chemical Properties

clear yellow liquid after melting

Uses

2,3,4-Trifluoronitrobenzene was employed as starting reagent in the synthesis of ofloxacin. It was also used in the synthesis of the third generation quinolones antibacterial drugs.

General Description

2,3,4-Trifluoronitrobenzene is a fluoronitrobenzene and its biotransformation under methanogenic conditions has been studied by semicontinuous and batch tests. 2,3,4-Trifluoronitrobenzene is an important pharmaceutical intermediate.

Synthesis

2,3,4-TRICHLORONITROBENZENE

17700-09-3

1,2,3-Trifluoro-4-nitrobenzene

771-69-7

General procedure for the synthesis of 2,3,4-trifluoronitrobenzene from 2,3,4-trichloronitrobenzene: (2) 240 g of DMSO and 120 g of 2,3,4-trichloronitrobenzene were added to an anhydrous reaction flask with stirring turned on, and the temperature was raised to 75-80 °C under reduced pressure with continuous stirring for 2 hours. Subsequently, 76.8 g of KF and 12 g of TBAB were added to the reaction system and dehydrated under reduced pressure at 75-80 °C for 2 h until no droplets of water fell from the distillation head. (3) The reaction system was slowly warmed up to 180 °C to start the reaction. The reaction process was monitored by gas chromatography (GC), and the reaction was completed when the content of both 2-fluoro-3,4-dichloronitrobenzene and 2,3-dichloro-4-fluoronitrobenzene decreased to less than 0.2% after 10 h. The reaction was completed when the content of 2-fluoro-3,4-dichloronitrobenzene and 2,3-dichloro-4-fluoronitrobenzene dropped below 0.2%. The reaction mixture was cooled to 70-75 °C, filtered, and the filtrate was vacuum distilled and reintroduced into the anhydrous reaction unit. 46 g of KF and 12 g of TBAF were added and dehydrated under reduced pressure at 75-80 °C for 2 h until no water droplets appeared in the distillation head. The reaction temperature was set to 120 °C and ultrasonic power to 20 kHz and the reaction was continued. The reaction was monitored by GC and completed after 2 hours. The reaction mixture was cooled to 70-75°C and filtered and the filtrate was distilled to separate DMSO from the product. The final yield of 2,3,4-trifluoronitrobenzene was 99.7%.

References

[1] Patent: CN107325001, 2017, A. Location in patent: Paragraph 0028-0029; 0031-0034; 0036-0039; 0041-0044; 0046

1,2,3-Trifluoro-4-nitrobenzene synthesis

2268-05-5
771-69-7
Synthesis of 1,2,3-Trifluoro-4-nitrobenzene from 1,3-Dichloro-2-fluorobenzene

1,2,3-Trifluoro-4-nitrobenzene Preparation Products And Raw materials

Raw materials

Potassium fluoride Sulfanilamide Fluoroboric acid Hydrochloric acid Nitric acid
2,5-Dichloroaniline 2,6-Dichloroaniline 1,2,3-Trifluorobenzene 3,5-dichloro-4-fluoroaniline 2,4-DICHLORO-3-FLUORONITROBENZENE
3,4,5-Trichloronitrobenzene 3,5-Dichloro-4-fluoronitrobenzene 1,3-Dichloro-2-fluorobenzene 3-CHLORO-2-FLUORONITROBENZENE Tetrabutylphosphonium bromide

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Preparation Products

RUFLOXACIN 2,3,4-Trifluorobenzenamine Lomefloxacin Levofloxacin Lomefloxacin hydrochloride
Ofloxacin 2-(2,3-Difluoro-6-nitrophenyl)acetic acid 2-FLUORORESORCINOL 2,3-Difluoro-4-nitroanisole

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1,2,3-Trifluoro-4-nitrobenzene Suppliers

Global( 422)Suppliers
Supplier Tel Email Country ProdList Advantage
.GZ HONESTCHEM CO.,LTD 		+8615013270415 honestchemical@foxmail.com China 300 58
Hebei Yanxi Chemical Co., Ltd. 		+8618531123677 faithe@yan-xi.com China 5853 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-86-13131129325 +8613131129325 sales1@chuanghaibio.com China 5228 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615531151365 mina@chuanghaibio.com China 18126 58
Anhui Zhongda Biotechnology Co., Ltd 		+8619956560829 justine@zhongda-biotech.com China 286 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20122 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
Hi-Tech Chemistry Corp 		0519-86626038 yuhh@hitechem.com CHINA 810 58
Speranza Chemical Co., Ltd. 		+86-86-075521030354 +8618688942810 sophieliu@speranzachem.com China 923 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29815 58
Supplier Advantage
.GZ HONESTCHEM CO.,LTD 		58
Hebei Yanxi Chemical Co., Ltd. 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Anhui Zhongda Biotechnology Co., Ltd 		58
Henan Fengda Chemical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Hi-Tech Chemistry Corp 		58
Speranza Chemical Co., Ltd. 		55
career henan chemical co 		58

View Lastest Price from 1,2,3-Trifluoro-4-nitrobenzene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1,2,3-Trifluoro-4-nitrobenzene pictures 2026-06-06 1,2,3-Trifluoro-4-nitrobenzene
771-69-7
 $1.00 300g 99.8% 20 TONS .GZ HONESTCHEM CO.,LTD
1,2,3-Trifluoro-4-nitrobenzene pictures 2026-05-28 1,2,3-Trifluoro-4-nitrobenzene
771-69-7
 $10.00 1KG 99.% 10 ton Hebei Chuanghai Biotechnology Co,.LTD
2,3,4-Trifluoronitrobenzene pictures 2026-03-06 2,3,4-Trifluoronitrobenzene
771-69-7
 100kg 99% 10 tons Shanghai Xinchem

1,2,3-Trifluoro-4-nitrobenzene Spectrum

1,2,3-Trifluoro-4-nitrobenzene(771-69-7)MS1,2,3-Trifluoro-4-nitrobenzene(771-69-7)1HNMR1,2,3-Trifluoro-4-nitrobenzene(771-69-7)13CNMR1,2,3-Trifluoro-4-nitrobenzene(771-69-7)IR1

771-69-7(1,2,3-Trifluoro-4-nitrobenzene)Related Search:

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2,6-Difluoronitrobenzene 4-Fluoronitrobenzene 1-Fluoro-2-nitrobenzene Nitrobenzene 2,3,4,5-Tetrafluoronitrobenzene
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3,4,5 TRIFLUORONITROBENZEN 2,3,4-Trifluornitrobenzene 4-chloro-2-fluroaniline 2,3,4-TRIFLUORONITROBRNZENE 1-nitro-2,3,4-trifluorobenzene 2,3,4-Trifluoronitrobenzene 99% 2,3,4-Trifluoronitrobenzene99% 2,3,4-TRIFLUORONITROBENZENEOFLOXACIN 1,2,3-Trifluoro-4-nitrobenzene, 4-Nitro-1,2,3-trifluorobenzene Benzene, 1,2,3-trifluoro-4-nitro- 1,2,3-Trifluoro-4-nitrobenzene,97% 1,2,3-Trifluoro-4-ni 4-Trifluoronitrobenzene 4-NITRO-1,2,3-TRIFLUOROBENZENE 1,2,3-TRIFLUORO-4-NITROBENZENE 2,3,4-TRIFLUORO-1-NITROBENZENE 1,2,3-Trifluoro-4-nitrobenzene ISO 9001：2015 REACH 1,2,3-Trifluor-4-nitrobenzol 2,3-Trifluoro-4-nitrobenzene 1,2,3-Trifluoro-4-nitrobenzen 2,3,4-TRIFLUORONITROBENZENE 771-69-7 71-69-7 C6H2NO2F3 C6H2F3NO2 Nitrogen Compounds Organic Building Blocks Nitro Compounds Building Blocks Fluorine series blocks FluoroCompounds NitroCompounds Aromatic Hydrocarbons (substituted) & Derivatives API intermediates OLED