Retigabine Dihydrochloride
- CAS No.
- 150812-13-8
- Chemical Name:
- Retigabine Dihydrochloride
- Synonyms
- D 20443;CS-2270;Retigabin.2HCl;Retigabine HCl;Retigabine 2HCL;Retigabine DiHCl;D20443 dihydrochloride;D-20443 dihydrochloride;D 20443 dihydrochloride;Retigabine HCl - Bio-X ?
- CBNumber:
- CB71565451
- Molecular Formula:
- C16H20Cl2FN3O2
- Molecular Weight:
- 376.2
- MDL Number:
- MFCD00912289
- MOL File:
- 150812-13-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 168-170°C |
|---|---|
| storage temp. | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| solubility | ≥18.8 mg/mL in DMSO; ≥52.4 mg/mL in H2O with gentle warming; ≥8.71 mg/mL in EtOH with gentle warming and ultrasonic |
| form | solid |
| Stability | Hygroscopic |
| FDA UNII | WV9W9019AP |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H413 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313-P273-P501 |
Retigabine Dihydrochloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 39309 | Retigabine (hydrochloride) ≥98% | 150812-13-8 | 1mg | $55 | 2026-04-30 | Buy |
| Cayman Chemical | 39309 | Retigabine (hydrochloride) ≥98% | 150812-13-8 | 5mg | $220 | 2026-04-30 | Buy |
| Biosynth | FR27709 | Retigabine dihydrochloride | 150812-13-8 | 500mg | $275 | 2026-06-04 | Buy |
| Biosynth | FR27709 | Retigabine dihydrochloride | 150812-13-8 | 1000mg | $450 | 2026-06-04 | Buy |
| Biosynth | FR27709 | Retigabine dihydrochloride | 150812-13-8 | 2000mg | $660 | 2026-06-04 | Buy |
Retigabine Dihydrochloride Chemical Properties, Uses, Production
Chemical Properties
Off-White Powder
Uses
A new experimental anticonvulsant drug. Anxiolytic.
Retigabine Dihydrochloride (0.1 ~ 10 μM) induced a potassium current and hyperpolarized CHO-KCNQ2/Q3 cells but not in wild-type cells. In the 6-Hz psychomotor seizure model, Retigabine Dihydrochloride dose-dependently blocked seizures induced by either 32 or 44 mA current stimulation.
Drug interactions
A clinical interaction study showed that there was no pharmacokinetic interaction between phenobarbitone and retigabine in healthy subjects. Thus, no dosage adjustment is likely to be necessary when phenobarbitone and retigabine are coadministered to patients
Biological Activity
Retigabine is a first-in-class k+ channel (kcnq) opener. kcnq channels are reported to be expressed predominantly in neurons and are critical determinants of cellular excitability, as shown by the occurrence of human genetic mutations in kcnq channels which underlie inheritable disorders including the syndrome of benign familial neonatal convulsions.
in vitro
retigabine was found to combine a novel mode of actions, which were namely potassium channel opening (kcnq2, kcnq3 as well as kcnq4 channels). retigabine also showed activities with some potentiation of gamma amino butyric acid (gaba)-evoked currents at its higher concentrations [1].
in vivo
animal models of epileptic seizures showed that retigabine treatment was effective at an oral dose as low as 0.01 mg/kg. studies performed in mice also indicated that combining retigabine with another anticonvulsant agent leads to an additive effect [1].
References
[1] ferron gm,patat a,parks v,rolan p,troy sm. lack of pharmacokinetic interaction between retigabine and phenobarbitone at steady-state in healthy subjects. br j clin pharmacol.2003 jul;56(1):39-45.
Retigabine Dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Wuhu Huaren Science and Technology Co., Ltd. | 5842013 18155347026 | xujuan@hdpharm.com | China | 255 | 64 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2110 | 70 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| China Nobel Chem Co., Limited | +86(0)21 60484900 | China | 762 | 50 |
View Latest Price from Retigabine Dihydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | Retigabine Dihydrochloride
150812-13-8
|
$60.00-150.00 | 10mg | 99% | 50 | Zibo Hangyu Biotechnology Development Co., Ltd | |
 |
2025-04-04 | Retigabine Dihydrochloride
150812-13-8
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2024-11-01 | Retigabine Dihydrochloride
150812-13-8
|
10g | 98%+ | 100kgs | Wuhan Nutra Biotechnology Co.,Ltd |
-
- Retigabine Dihydrochloride
150812-13-8
- $60.00-150.00
- 99%
- Zibo Hangyu Biotechnology Development Co., Ltd
-
- Retigabine Dihydrochloride
150812-13-8
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- Retigabine Dihydrochloride
150812-13-8
- 98%+
- Wuhan Nutra Biotechnology Co.,Ltd
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