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2'-Deoxyadenosine

2'-Deoxyadenosine structure

CAS No.: 958-09-8

Chemical Name:: 2'-Deoxyadenosine

Synonyms: DA;DEOXYADENOSINE;IFN-α;(2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol;2'-dA;-dA CEP;2'-dA·H2O;DESOXYADENOSINE;8-Bromo-2’8-Amino-2&rsquo

CBNumber:: CB7162318

Molecular Formula:: C10H13N5O3

Molecular Weight:: 251.24

MDL Number:: MFCD00005754

MOL File:: 958-09-8.mol

MSDS File:: SDS

Last updated:2025-11-11 10:47:11

Product description	Number	Pack Size	Price
2'-Deoxyadenosine Anhydrous >98.0%(HPLC)(T)	D4137	5g	$129
2’-Deoxyadenosine	D239583	5g	$45
2'-Deoxyadenosine - isolated from DNA	FD158139	1g	$50
2'-Deoxyadenosine	BID1006	10g	$51
2'-Deoxyadenosine	K731	5g	$25
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2'-Deoxyadenosine Properties

Melting point	187-189 °C
Boiling point	394.4°C (rough estimate)
Density	1.2938 (rough estimate)
refractive index	1.7610 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	DMSO (Slightly), Methanol (Slightly), Water (Slightly)
pka	pK1:3.8(+1) (25°C,μ=0.1)
form	powder
color	White
PH	3.8
Water Solubility	Soluble in water and caustic soda.
λmax	258 (pH 2)；260 (pH 7)
Stability	Hygroscopic
InChI	InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1
InChIKey	OLXZPDWKRNYJJZ-RRKCRQDMSA-N
SMILES	OC[C@H]1O[C@@H](N2C3C(=C(N=CN=3)N)N=C2)C[C@@H]1O
CAS DataBase Reference	958-09-8(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	P582C98ULC
NIST Chemistry Reference	Deoxyadenosine(958-09-8)
EPA Substance Registry System	Adenosine, 2'-deoxy- (958-09-8)
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H301

Precautionary statements

P264-P270-P301+P310

RIDADR

2811

WGK Germany

RTECS

AU7358600

10-23

TSCA

Yes

HazardClass

6.1

PackingGroup

Ⅲ

HS Code

2934999090

NFPA 704

	1
1		0

2'-Deoxyadenosine price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	D4137	2'-Deoxyadenosine Anhydrous >98.0%(HPLC)(T)	958-09-8	5g	$129	2025-07-31	Buy
TRC	D239583	2’-Deoxyadenosine	958-09-8	5g	$45	2021-12-16	Buy
Biosynth Carbosynth	FD158139	2'-Deoxyadenosine - isolated from DNA	958-09-8	1g	$50	2021-12-16	Buy
Apolloscientific	BID1006	2'-Deoxyadenosine	958-09-8	10g	$51	2021-12-16	Buy
AK Scientific	K731	2'-Deoxyadenosine	958-09-8	5g	$25	2021-12-16	Buy

Product number	Packaging	Price	Buy
D4137	5g	$129	Buy
D239583	5g	$45	Buy
FD158139	1g	$50	Buy
BID1006	10g	$51	Buy
K731	5g	$25	Buy

2'-Deoxyadenosine Chemical Properties,Uses,Production

Description

2'-Deoxyadenosine is a natural deoxyribonucleoside, which is a structural fragment of deoxyribonucleic acid DNA. It is a purine nucleoside component of DNA comprised of adenosine linked by its N9 nitrogen to the C1 carbon of deoxyribose. Like other natural nucleosides, it is involved in the transmission of genetic information in almost all biological cells, affecting protein synthesis and polysaccharide. It plays a very important role in regulating the growth, proliferation, differentiation and inhibition of cells in vivo.

Uses

2'-Deoxyadenosine is used in paradoxical stimulation study of human sperm motility. It plays an essential role as sperm motility stimulants used in sperm micro-injection on mouse and human embryo development. It finds an application in some cells as an energy source under energy stress conditions. It is involved in various biological processes to compare the functions of adenosine analogues.

Definition

ChEBI: 2'-deoxyadenosine is a purine 2'-deoxyribonucleoside having adenine as the nucleobase. It has a role as a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a purines 2'-deoxy-D-ribonucleoside and a purine 2'-deoxyribonucleoside.

Preparation

2'-deoxyadenosine synthesis: esterification of adenosine, acylation of an acylating agent and an acid binding agent to obtain an acylate; the obtained acylate is then subjected to reduction and purification to obtain 2'-deoxyadenosine. The esterification agent used in the esterification process is dialkyl tin oxide, 2'-O-p-toluenesulfonyladenosine is synthesized from adenosine, and 2'-deoxyadenosine is synthesized from 2'-O-p-toluenesulfonyladenosine glycosides.

benefits

2'-Deoxyadenosine is an adenine nucleoside and a component of DNA. It plays an important role in many biological processes in the human body and has the following benefits:
(1) Provides energy to the human body and affects cAMP levels
(2) Enhances skin repair and maintains skin health
(3) Improves heart health and fights inflammation, cancer, diabetes and aging.
(4) Inhibits the growth of viruses and certain cancer cells

Biological Functions

2'-Deoxyadenosine (Deoxyadenosine) is a critical component of DNA. When present in sufficiently high levels, deoxyadensoine can act as an immunotoxin and a metabotoxin. An immunotoxin disrupts, limits the function, or destroys immune cells. A metabotoxin is an endogenous metabolite that causes adverse health effects at chronically high levels.

Biological Activity

2'-Deoxyadenosine is a deoxyribonucleoside and an intermediate in the purine nucleotide degradation pathway. It is transported into cells via facilitated diffusion or formed within cells by degradation of S-adenosylhomocysteine or AMP and is removed from cells by purine metabolism or is converted into adenine nucleotides. 2'-Deoxyadenosine has been used in the characterization of DNA conformations and the synthesis of nucleoside analogs as antiviral agents.

Source

2'-Deoxyadenosine is a metabolite found in or produced by Escherichia coli (strain K12, MG1655). 2'-Deoxyadenosine is a natural product found in Streptomyces jiujiangensis, Fritillaria przewalskii, and other organisms with data available.

2'-Deoxyadenosine synthesis

Synthesis of 2'-Deoxyadenosine from 9H-Purin-6-amine, 9-[2-deoxy-3,5-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]-β-L-erythro-pentofuranosyl]-

2'-Deoxyadenosine Preparation Products And Raw materials

Raw materials

Preparation Products

5'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYADENOSINE N6-PHEAC-DEOXYADENOSINE 8-BROMO-2'-DEOXYADENOSINE PHTHALAMIDE N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine

2'-Deoxyadenosine 5'-phosphate 7-METHYLGUANINE N6,N6-dibenzoyl-3',5'-O-dibenzoyl-2'-deoxyadenosine

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2'-Deoxyadenosine Suppliers

Global( 476)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Wuhu Nuowei chemistry Co., Ltd.	+86-0553-2911116-802 +86-18055326116	sales1@nuowei-chem.com	China	1627	58
Yunbio Tech Co.,Ltd.	+86-010-60605551 +86-18046518538	yunbiochem@126.com	China	321	58
SHANGHAI NOVRIBO BIOTECH	17821030819	June.Liu@Desano.com	China	73	58
Hangzhou Measure Life Technology Co., LTD	+8613343730176	2924244016@qq.com	China	83	58
Xinxiang Aurora Biotechnology Co.,Ltd.	+86-0086-0373-3088722 +8618637352520	info@aurora-biotech.com	China	112	58
INNOBIO PHARM CO.,LTD	+8615600141006	cindyyb@126.com	China	279	58
Zhengzhou Youmei Medical Technology Co., Ltd.	+8615716484486	495737714@qq.com	China	7	58
WeiTai BioPharmaceutical Co.,Ltd(Hangzhou?)	+86-86-057182358004 +8613588879771	info@weitai-pharmaceutical.com	China	61	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
HangZhou RunYan Pharma Technology Co.,LTD.	+8618882027439	sales2@runyanpharma.com	China	302	58

Supplier	Advantage
Wuhu Nuowei chemistry Co., Ltd.	58
Yunbio Tech Co.,Ltd.	58
SHANGHAI NOVRIBO BIOTECH	58
Hangzhou Measure Life Technology Co., LTD	58
Xinxiang Aurora Biotechnology Co.,Ltd.	58
INNOBIO PHARM CO.,LTD	58
Zhengzhou Youmei Medical Technology Co., Ltd.	58
WeiTai BioPharmaceutical Co.,Ltd(Hangzhou?)	58
Hebei Chuanghai Biotechnology Co., Ltd	58
HangZhou RunYan Pharma Technology Co.,LTD.	58

How to synthesize of 2′-deoxyadenosine and its derivatives
2′-Deoxyadenosine has extraordinary strong potentials as a intermediate compound of anti-cancer and anti-viral nucleoside drug....
May 20，2025

What diseases are 2'-Deoxyadenosine levels associated with?
2'-Deoxyadenosine is a derivative of the adenosine nucleoside with adenine (A) as the nucleobase, which pairs with deoxythymid....
Nov 4，2024

Synthesis and Bioactivity of 2'-Deoxyadenosine
2'-Deoxyadenosine can also be used as an important intermediate for antiviral, anticancer and anti-AIDS drugs.
Sep 26，2022

Related Qustion

Ask a question

Q:What are the benefits of 2'-Deoxyadenosine supplementation?STAR - Nov 6，2025

A:2'-Deoxyadenosine (2'-dA) is a nucleoside involved in DNA replication, holding significant importance for maintaining human health. Supplementation with 2'-Deoxyadenosine may help enhance its anti-ageing properties and improve skin repair and cellular renewal capabilities. As a stimulator of epidermal adenylate cyclase, 2'-dA has been demonstrated to effectively inhibit keratinocyte proliferation.

Q:What is the difference between adenosine and deoxyadenosine?STAR - Nov 6，2025

A:Adenosine and deoxyadenosine are both nucleosides containing the nitrogenous base adenine. The primary distinction between them lies in the structural presence of a ribose moiety in adenosine, whereas deoxyadenosine incorporates a deoxyribose moiety. Adenosine is one of the four nucleoside components of RNA, whereas deoxyadenosine is one of the four nucleoside components of DNA. The adenosine structure contains the nitrogenous base adenine and a ribose moiety, with no attached phosphate group. The molecule consists of adenine connected to the ribose moiety via a β-N-glycosidic bond. The deoxyadenosine structure incorporates a deoxyribose moiety. This differs from adenosine. In deoxyadenosine, the hydroxyl group at the 2' position of the sugar moiety is replaced by a hydrogen atom. This substitution transforms the ribose moiety into a deoxyribose moiety.

View Lastest Price from 2'-Deoxyadenosine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-11-24	2'-Deoxyadenosine 958-09-8	US $1.00 / g	10g	≥98%	10kgs/month	WUHAN FORTUNA CHEMICAL CO., LTD
2025-11-21	2'-Deoxyadenosine 958-09-8	US $5.00-0.50 / KG	0.10000000149011612KG	99% hplc	5000kg	Wuhan JiyunZen Tech Co., Ltd.
2025-11-10	2'-Deoxyadenosine 958-09-8	US $55.00-39.00 / mg		99.85%	10g	TargetMol Chemicals Inc.

2'-Deoxyadenosine
958-09-8
US $1.00 / g
≥98%
WUHAN FORTUNA CHEMICAL CO., LTD

2'-Deoxyadenosine
958-09-8
US $5.00-0.50 / KG
99% hplc
Wuhan JiyunZen Tech Co., Ltd.

2'-Deoxyadenosine
958-09-8
US $55.00-39.00 / mg
99.85%
TargetMol Chemicals Inc.

2'-Deoxyadenosine Spectrum

2'-Deoxyadenosine(958-09-8)MS 2'-Deoxyadenosine(958-09-8)¹HNMR 2'-Deoxyadenosine(958-09-8)¹³CNMR 2'-Deoxyadenosine(958-09-8)IR1 2'-Deoxyadenosine(958-09-8)IR2

958-09-8(2'-Deoxyadenosine )Related Search:

Adenosine5'-(tetrahydrogen triphosphate), disodiuM salt, trihydrate (9CI) Vidarabine ADENOSINE 5'-TRIPHOSPHATASE Deoxycholic acid Coenzyme B12

Cyclic AMP 2'-Deoxyadenosine 5'-phosphate Dideoxyadenosine ADP 2'-Deoxyadenosine-5'-triphosphate, trisodiuM salt

c-di-AMP ADENOSINE-2':3'-CYCLIC MONOPHOSPHATE, SODIUM SALT [5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-oxolan-2-yl]methoxyphosphonic acid 2'-O-Methyladenosine ADENOSINE 2' -& 3'-MONOPHOSPHATE FREE

[(2R,5R)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxy-oxolan-2-yl]me thoxyphosphonic acid 3'-ADENYLIC ACID 6-METHYLAMINOPURINE 9-RIBOFURANOSIDE

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(2R,3S,5R)-5-(6-AMINO-PURIN-9-YL)-2-HYDROXYMETHYL-TETRAHYDRO-FURAN-3-OL 2'-DEOXY-D-ADENOSINE 2'-Deoxyadenosineanhydrous 2'-dA·H2O (2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol 2'-Deoxy-a-adenosine 2’-deoxy-adenosin 9-(2-Deoxy-beta-D-erythro-pentofuranosyl)adenine 9H-Purin-6-amine, 9-(2-deoxy-beta-D-erythro-pentofuranosyl)- 9H-Purin-6-amine, 9-(2-deoxy-beta-D-ribofuranosyl)- Adenine deoxy nucleoside Adenine deoxyribonucleoside 2''-DEOXYADENOSINE (isolated from DNA) 3-Deaza-3-methyl-2&rsquo -dA CEP 2'-Deoxyadenosine(Da) adeninedeoxyribonucleoside adeninedeoxyribose Adenosine, 2'-deoxy- Adenyldeoxyriboside beta-D-Erythro-Pentofuranoside, adenine-9 2-deoxy- beta-D-Ribofuranose, 1-(6-amino-9H-purin-9-yl)-1,2-dideoxy- ADENINE DESOXYRIBOSIDE DA DEOXYADENOSINE DEOXYADENOSINE-2' DESOXYADENOSINE 9-(2'-DEOXY-BETA-D-RIBOFURANOSYL)ADENINE N6-(6-Aminohexyl)-2&rsquo -deoxyadenosine-13C2,15N 6-N-Acyl-6-N-methyl-2&rsquo 8-Bromo-2&rsquo N6-Benzoyl-8-oxo-2&rsquo 8-Amino-2&rsquo 2-Amino-N2-isobutyryl-2&rsquo 2-Amino-5&rsquo -O-(dimethoxytrityl)-N6-(dimethylaminomethylidene)-N2-isobutyryl-2&rsquo 8-Bromo-N6-(dimethylaminomethylidene)-2&rsquo N6-Benzoyl-5&rsquo -O-(dimethoxytrityl)-8-oxo-2&rsquo 2-Methoxy 2&rsquo N6-Benzoyl-8-benzyloxy-2&rsquo 2-Fluoro-2&rsquo 8-Azido-2&rsquo 7-(3-Nitrophenyl)-7-deaza-2&rsquo 2'-Deoxyadenosine anhydrate 2'-DeoxyadenosineAnhydrous> IFN-α 2'-Deoxyadenosine USP/EP/BP 2'-Deoxyadenosine-WIDELY 2'-Deoxyadenosine Anhydrous, ≥ 98.0% 2'-Deoxyadenosine 2'-Deoxyadenosine(2'-dA) 2'-Deoxyadenosine Anhydrous (2'-dA) 2'-DeoxyAdenosine 2'-dA Medetomidine Impurity 67 Monkey Interferon Alpha (IFNa)ELISA Kit