Piperonylic acid
- CAS No.
- 94-53-1
- Chemical Name:
- Piperonylic acid
- Synonyms
- Benzo[d][1,3]dioxole-5-carboxylic acid;Heliotropic acid;1,3-BENZODIOXOLE-5-CARBOXYLIC ACID;PIPEROYLICACID;3,4-(METHYLENEDIOXY)BENZOIC ACID;AKOS 213-90;Pepper acid;heliotropicacid;PIPERONYLIC ACID;PiperonylicAcid>
- CBNumber:
- CB7162666
- Molecular Formula:
- C8H6O4
- Molecular Weight:
- 166.13
- MDL Number:
- MFCD00005830
- MOL File:
- 94-53-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Piperonylic acid 99% | P49805 | 5g | $64.7 |
| Piperonylic acid 99% | P49805 | 25g | $108 |
| Piperonylic Acid >98.0%(GC)(T) | P0459 | 25g | $43 |
| Piperonylic Acid | P490450 | 5g | $50 |
| Piperonylic Acid | 462686 | 5g | $319 |
| More product size | |||
| Melting point | 229-231 °C (lit.) |
|---|---|
| Boiling point | 254.32°C (rough estimate) |
| Density | 1.3579 (rough estimate) |
| refractive index | 1.5090 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 4.35±0.20(Predicted) |
| form | Powder |
| color | Off-white to beige |
| Water Solubility | slightly soluble |
| Merck | 14,7477 |
| BRN | 150206 |
| Cosmetics Ingredients Functions |
SKIN PROTECTING SKIN CONDITIONING |
| InChI | 1S/C8H6O4/c9-8(10)5-1-2-6-7(3-5)12-4-11-6/h1-3H,4H2,(H,9,10) |
| InChIKey | VDVJGIYXDVPQLP-UHFFFAOYSA-N |
| SMILES | OC(=O)c1ccc2OCOc2c1 |
| LogP | 0.810 (est) |
| CAS DataBase Reference | 94-53-1(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | QX3V1NO0KH |
| NIST Chemistry Reference | 1,3-Benzodioxole-5-carboxylic acid(94-53-1) |
| EPA Substance Registry System | 1,3-Benzodioxole-5-carboxylic acid (94-53-1) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H318-H335-H319 | |||||||||
| Precautionary statements | P264-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P280a-P304+P340-P405-P501a-P261-P280-P305+P351+P338 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-37/38-41-36/37/38 | |||||||||
| Safety Statements | 26-36/37/39-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DF4912765 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29329970 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
Piperonylic acid price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P49805 | Piperonylic acid 99% | 94-53-1 | 5g | $64.7 | 2026-04-30 | Buy |
| Sigma-Aldrich | P49805 | Piperonylic acid 99% | 94-53-1 | 25g | $108 | 2026-04-30 | Buy |
| TCI Chemical | P0459 | Piperonylic Acid >98.0%(GC)(T) | 94-53-1 | 25g | $43 | 2026-04-30 | Buy |
| TRC | P490450 | Piperonylic Acid | 94-53-1 | 5g | $50 | 2021-12-16 | Buy |
| Usbiological | 462686 | Piperonylic Acid | 94-53-1 | 5g | $319 | 2021-12-16 | Buy |
Piperonylic acid Chemical Properties,Uses,Production
Chemical Properties
It is a white to light yellow crystalline powder, slightly soluble in water, chloroform, cold ethanol, and ether.
Uses
Piperonylic Acid is a compound closely mimicking the structure of transcinnamic acid involved in the phenylpropanoid pathway in plant physiology.
Definition
ChEBI: Piperonylic acid is a member of the class of benzodioxoles that is 1,3-benzodioxole substituted by a carboxy group at position 5. It is a natural product isolated from several plant species. It is a selective mechanism-based inactivator of the trans-cinnamate 4-hydroxylase enzyme and exhibits antifungal and skin wound healing properties. It has a role as a plant metabolite, an EC 1.14.14.91 ( trans-cinnamate 4-monooxygenase) inhibitor, a vulnerary and an antifungal agent. It is a member of benzodioxoles, a monocarboxylic acid and an aromatic carboxylic acid. It is a conjugate acid of a piperonylate.
Synthesis Reference(s)
The Journal of Organic Chemistry, 40, p. 3803, 1975 DOI: 10.1021/jo00913a051
Purification Methods
Crystallise the acid from EtOH or water. [Beilstein 19/7 V 300.]
References
[1] OTTO RICHARD GOTTLIEB MAURO T M. Isolation of Piperonylic Acid from Ocotea pretiosa[J]. Nature, 1958, 182 4637: 742-743. DOI:10.1038/182742b0.
[2] SEUNG HYUN HAN. Piperonylic Acid Promotes Hair Growth by Activation of EGFR and Wnt/β-Catenin Pathway.[J]. International Journal of Molecular Sciences, 2024, 25 19. DOI:10.3390/ijms251910774.
[3] SCHALK. Piperonylic acid, a selective, mechanism-based inactivator of the trans-cinnamate 4-hydroxylase: A new tool to control the flux of metabolites in the phenylpropanoid pathway[J]. Plant Physiology, 1998, 118 1: 209-218. DOI:10.1104/pp.118.1.209.
Piperonylic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Nanjing Deda New Material Technology Co., Ltd | +8613223293093 | bella@njdeda.com | China | 80 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5235 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21590 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29819 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2949 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
Related articles
- The biological activity of Piperonylic acid
- Piperonylic acid is a natural molecule bearing a methylenedioxy function that closely mimics the structure of transcinnamic ac....
- May 20，2025
View Lastest Price from Piperonylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-30 | Piperonylic acid
94-53-1
|
US $0.00 / Kg/Drum | 1KG | 99% | 200mt/year | Jinan Finer Chemical Co., Ltd | |
 |
2026-03-20 | Piperonylic acid
94-53-1
|
US $10.00 / KG | 1KG | 99% | 100 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2026-03-12 | Piperonylic acid
94-53-1
|
US $0.00 / mg | 10mg | 0.98 | 10g | ShenZhen H&D Pharmaceutical Technology Co., LTD |
-
- Piperonylic acid
94-53-1
- US $0.00 / Kg/Drum
- 99%
- Jinan Finer Chemical Co., Ltd
-
- Piperonylic acid
94-53-1
- US $10.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Piperonylic acid
94-53-1
- US $0.00 / mg
- 0.98
- ShenZhen H&D Pharmaceutical Technology Co., LTD
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