Dibenzoylmethane
- CAS No.
- 120-46-7
- Chemical Name:
- Dibenzoylmethane
- Synonyms
- DBM;1,3-diphenylpropane-1,3-dione;1,3-DIPHENYL-1,3-PROPANEDIONE;1,3-Diphenylpropanedione;1,3-diphenyl-3-propanedione;karenzudk2;phenylphenacylketone;2-Benzoylacetophenone;Phenyl phenacyl ketone;DBM83
- CBNumber:
- CB7175433
- Molecular Formula:
- C15H12O2
- Molecular Weight:
- 224.25
- MDL Number:
- MFCD00003085
- MOL File:
- 120-46-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 77-79 °C(lit.) |
|---|---|
| Boiling point | 219-221 °C18 mm Hg(lit.) |
| Density | 0.800 g/cm3 |
| vapor pressure | 0.01Pa at 20℃ |
| refractive index | 1.6600 (estimate) |
| Flash point | 219-221°C/18mm |
| storage temp. | Store below +30°C. |
| solubility | Chloroform (Slightly), Methanol (Slightly, Sonicated) |
| pka | 8.95±0.10(Predicted) |
| form | Crystals |
| color | Light yellow to yellow |
| Water Solubility | It is Soluble in ether, chloroform, and aqueous sodium hydroxide. Insoluble in water. |
| Merck | 14,3009 |
| BRN | 514910 |
| Henry's Law Constant | 7.5×103 mol/(m3Pa) at 25℃, Zhang et al. (2010) |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChI | 1S/C15H12O2/c16-14(12-7-3-1-4-8-12)11-15(17)13-9-5-2-6-10-13/h1-10H,11H2 |
| InChIKey | NZZIMKJIVMHWJC-UHFFFAOYSA-N |
| SMILES | O=C(CC(=O)c1ccccc1)c2ccccc2 |
| LogP | 4.59 at 25℃ |
| CAS DataBase Reference | 120-46-7(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | ANS7ME8OKC |
| NIST Chemistry Reference | 1,3-Propanedione, 1,3-diphenyl-(120-46-7) |
| EPA Substance Registry System | 1,3-Propanedione, 1,3-diphenyl- (120-46-7) |
| UNSPSC Code | 12352115 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P271-P280 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TZ1930000 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29143900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Toxicity | rat,LD,oral,> 500mg/kg (500mg/kg),National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. Vol. 5, Pg. 28, 1953. | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
Dibenzoylmethane price More Price(86)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D33454 | 1,3-Diphenyl-1,3-propanedione 98% | 120-46-7 | 25g | $59.9 | 2026-04-30 | Buy |
| Sigma-Aldrich | D33454 | 1,3-Diphenyl-1,3-propanedione 98% | 120-46-7 | 100g | $220 | 2026-04-30 | Buy |
| TCI Chemical | D0910 | 1,3-Diphenyl-1,3-propanedione >98.0%(GC) | 120-46-7 | 25g | $20 | 2026-04-30 | Buy |
| TCI Chemical | D0910 | 1,3-Diphenyl-1,3-propanedione >98.0%(GC) | 120-46-7 | 100g | $38 | 2026-04-30 | Buy |
| Usbiological | 273859 | 1,3-Diphenyl-1,3-propanedione Asreported | 120-46-7 | 250g | $382 | 2026-06-03 | Buy |
Dibenzoylmethane Chemical Properties, Uses, Production
Chemical Properties
Dibenzoylmethane (DB), a minor constituent of the root extract of licorice, belongs to the flavonoid family. It is a colorless rhombus flake crystal or yellowish-white powder. soluble in chlorohydrin and chloroform, soluble in sodium hydroxide solution, insoluble in sodium carbonate solution, and very slightly soluble in water. It is used as a colorimetric reagent for the determination of uranium.
Occurrence
Dibenzoylmethane(DBM) is a 1,3-diketone derivative of acetylacetone that has both methyl groups replaced with phenyl groups.Although smaller in size and lacking hydroxyl and methoxy groups，DBM resembles the turmeric spice curcumin (CUR),a diferuloylmethane. Both molecules are metal-chelating agents，contain a B-diketone flanked by two aryl groups,and exhibit anti-proliferative and anticarcinogenic activity. In addition to sharing structural similarity with DBM,CUR,which is also a naturally occurring compound is found in the plant Curcuma longa and has numerous medicinal uses.
DBM and its many naturally occurring derivatives are minor constituentsof licorice. DBM has been isolated from licorice root extracts and otherspecies of Glycyrrhiza.
Uses
Dibenzoylmethane is a new kind of PVC heat stabilizer, it has better transparency, nontoxic and odorless. In case of combined use with Calcium/Zinc, Barium/Zin and other heat stabilizer, it can greatly improve the initial color, transparency, long term stability of PVC, and also can improve the precipitation and “zinc burning” problem during the process. It has very good synergy with zinc soaps, and can protect the PVC color. This material can absorb UV at 290nm, which has the effect as light stabilizer and act as long term stabilizer for PVC products.
Uses
Dibenzoylmethane is a compound known to inhibit tumorigenesis in mice.
Definition
ChEBI: Dibenzoylmethane is a beta-diketone that is acetylacetone (acac) in which both methyl groups have been replaced by phenyl groups. It is a minor constituent of the root extract of licorice (Glycyrrhiza glabra) and exhibits antimutagenic and anticancer effects. It has a role as an antineoplastic agent, a metabolite and an antimutagen. It is a beta-diketone and an aromatic ketone.
Preparation
dibenzoylmethane is prepared by condensation of ethyl benzoate with acetophenone.
Synthesis Reference(s)
Tetrahedron Letters, 37, p. 3885, 1996 DOI: 10.1016/0040-4039(96)00689-2
Chemical and Pharmaceutical Bulletin, 29, p. 2762, 1981 DOI: 10.1248/cpb.29.2762
Flammability and Explosibility
Non flammable
Biological Activity
In a screen of 300 compounds for those that regulate ER stress, the DBM (Dibenzoylmethane) derivative 14-26 (2,2'-dimethoxydibenzoylmethane) was identified as a novel neuroprotective agent. Other DBM derivatives that have been successfully used in protection against ER stress are 4,4'-dibromodibenzoylmethane and 4,4'-dichlorodibenzoyl-methane. Both compounds showed their protective effect against ER stress in F9 homocysteine-induced ER protein (Herp)-null cells treated with Tm[1].
Safety Profile
Moderately toxic by ingestion. When heated to decomposition it emits acrid smoke and irritating vapors
Purification Methods
Dibenzoylmethane (1,3-diphenyl-1,3-propanedione) [120-46-7] M 224.3, m 8 0o. Crystallise dibenzoylmethane from pet ether or MeOH. [Beilstein 7 IV 2512.]
References
[1] HONORATA KRASKIEWICZ Una F. InterfERing with endoplasmic reticulum stress.[J]. Trends in pharmacological sciences, 2012, 33 2: 53-63. DOI:10.1016/j.tips.2011.10.002.
Dibenzoylmethane Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan beileye Biomedical Technology Co., Ltd | 15871353653 18086118076 | 1784708432@qq.com | China | 4746 | 58 |
| Nanjing Deweiqi Chemical Technology Co., Ltd | 18652911584 | 381854775@qq.com | China | 319 | 58 |
| Tianjin Zhongxin Chemtech Co., Ltd. | 022-66880623 | sales@tjzxchem.com | China | 612 | 60 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
Related articles
- Dibenzoylmethane: Biological Activities and Mechanisms
- Dibenzoylmethane is a metal-chelating agent with anti-proliferative and anticarcinogenic activities against various cancers.
- Jun 3,2025
View Latest Price from Dibenzoylmethane manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-17 | Dibenzoylmethane
120-46-7
|
$1.00 | 1KG | ≥99% | 2000mt/year | Jinan Finer Chemical Co., Ltd | |
 |
2026-09-17 | dibenzoylmethane
120-46-7
|
1KG | 99.9% | 100 | Wuhan Biet Co., Ltd. | ||
 |
2026-08-12 | Dibenzoylmethane
120-46-7
|
$9680.00 | 1T | 98% | 1-250mt | Baoji Guokang Healthchem Co., Ltd. |
-
- Dibenzoylmethane
120-46-7
- $1.00
- ≥99%
- Jinan Finer Chemical Co., Ltd
-
- dibenzoylmethane
120-46-7
- $0.00
- 99.9%
- Wuhan Biet Co., Ltd.
-
- Dibenzoylmethane
120-46-7
- $9680.00
- 98%
- Baoji Guokang Healthchem Co., Ltd.
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