4-Amino-3-pyridinecarboxylic acid
- CAS No.
- 7418-65-7
- Chemical Name:
- 4-Amino-3-pyridinecarboxylic acid
- Synonyms
- 4-AMINONICOTINIC ACID;4-AMINOPYRIDINE-3-CARBOXYLIC ACID;H-4ANIC-OH;AURORA KA-2553;AKOS BBS-00001375;IFLAB-BB F1957-0006;RARECHEM AL BE 1386;4-Aminonicotinc acid;4-AminonicotinicAcid98%;4-Aminonicotinic acid 99%
- CBNumber:
- CB7184989
- Molecular Formula:
- C6H6N2O2
- Molecular Weight:
- 138.12
- MDL Number:
- MFCD00234183
- MOL File:
- 7418-65-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4-Amino-nicotinic acid ≥97.0% (HPLC) | 11585 | 5G | $76.1 |
| 4-amino Nicotinic Acid ≥98% | 20733 | 1g | $36 |
| 4-amino Nicotinic Acid ≥98% | 20733 | 5g | $103 |
| 4-amino Nicotinic Acid ≥98% | 20733 | 10g | $169 |
| 4-amino Nicotinic Acid ≥98% | 20733 | 25g | $336 |
| More product size | |||
| Melting point | 307-312 °C |
|---|---|
| Boiling point | 253.51°C (rough estimate) |
| Density | 1.3471 (rough estimate) |
| refractive index | 1.5100 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Soluble in aqueous acid and base. |
| pka | 2.94±0.10(Predicted) |
| form | Powder |
| color | Cream to yellow |
| Major Application | peptide synthesis |
| InChI | InChI=1S/C6H6N2O2/c7-5-1-2-8-3-4(5)6(9)10/h1-3H,(H2,7,8)(H,9,10) |
| InChIKey | IASBMUIXBJNMDW-UHFFFAOYSA-N |
| SMILES | C1=NC=CC(N)=C1C(O)=O |
| CAS DataBase Reference | 7418-65-7(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | N | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
4-Amino-3-pyridinecarboxylic acid price More Price(93)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 11585 | 4-Amino-nicotinic acid ≥97.0% (HPLC) | 7418-65-7 | 5G | $76.1 | 2025-07-31 | Buy |
| Cayman Chemical | 20733 | 4-amino Nicotinic Acid ≥98% | 7418-65-7 | 1g | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 20733 | 4-amino Nicotinic Acid ≥98% | 7418-65-7 | 5g | $103 | 2026-04-30 | Buy |
| Cayman Chemical | 20733 | 4-amino Nicotinic Acid ≥98% | 7418-65-7 | 10g | $169 | 2026-04-30 | Buy |
| Cayman Chemical | 20733 | 4-amino Nicotinic Acid ≥98% | 7418-65-7 | 25g | $336 | 2026-04-30 | Buy |
4-Amino-3-pyridinecarboxylic acid Chemical Properties,Uses,Production
Description
4-amino Nicotinic acid is a synthetic intermediate that has been used in various syntheses.
Chemical Properties
Light yellow Cryst
Uses
4-Aminonicotinic acid has been used in the preparation of 2-methyl-pyrido-oxazine. It is also used as pharmaceutical intermediate.
Definition
ChEBI: 4-aminonicotinic acid is an aminonicotinic acid in which the amino group is situated at position 4 of the pyridine ring. It has a role as a metabolite. It is an aromatic amine, an aminopyridine and an aminonicotinic acid. It is functionally related to a 4-aminopyridine and a nicotinic acid.
General Description
4-Amino-nicotinic acid is a white to light yellow and faint beige to light beige and faint brown to light brown powder or crystals.
Synthesis
16135-36-7
7418-65-7
The general procedure for the synthesis of 4-aminopyridine-3-carboxylic acid from 4-aminonicotinic acid methyl ester was as follows: to an aqueous ethanol solution of 4-aminopyridine-3-carboxylic acid methyl ester (2 g, 13.15 mmol) in stirring (120 mL, V/V=1:1) was added LiOH-H2O (1.21 g, 28.80 mmol) at room temperature, and the reaction mixture was subsequently heated to 80°C for 2 h (the progress of the reaction was monitored by TLC to confirm complete consumption of the feedstock). After completion of the reaction, the volatiles were removed under reduced pressure to give the crude product. The crude product was dissolved in water (30 mL) and washed with ethyl acetate (2 x 25 mL) to remove non-polar impurities. The aqueous layer was acidified to pH=1 with 1N HCl solution and subsequently extracted with ethyl acetate (2 x 10 mL). The organic extracts were combined and concentrated under reduced pressure to give a crude residue. The crude product was purified by crystallization from methanol (20 mL) to give finally 4-aminopyridine-3-carboxylic acid (1 g, 55% yield) as an off-white solid.LCMS (ESI+): m/z: 139.31 [M+H]+.
References
[1] Patent: WO2018/125961, 2018, A1. Location in patent: Page/Page column 98; 99; 100
4-Amino-3-pyridinecarboxylic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21586 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2994 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | 52513593@qq.com | CHINA | 2972 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19936 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| Shenzhen Excellent Biotech Co., Ltd. | 13480692018 | ramyan@ex-biotech.com | CHINA | 954 | 58 |
View Lastest Price from 4-Amino-3-pyridinecarboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 4-Amino-3-pyridinecarboxylic acid
7418-65-7
|
$8.00 | 1KG | 99% | 10tons | Career Henan Chemical Co |
-
- 4-Amino-3-pyridinecarboxylic acid
7418-65-7
- $8.00
- 99%
- Career Henan Chemical Co
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