GSK-CXCR2
- CAS No.
- 211096-49-0
- Chemical Name:
- GSK-CXCR2
- Synonyms
- SB 265610;GSK-CXCR2;SB 265610 ，S9516;SB265610 >=98% (HPLC);SB-265610, 10 mM in DMSO;N-(2-Bromophenyl)-N'-(7-cyano-1H-benzotriazol-4-yl)urea;Urea, N-(2-bromophenyl)-N'-(4-cyano-1H-benzotriazol-7-yl)-;1-(2-Bromophenyl)-3-(4-cyano-1H-benzo[d] [1,2,3]triazol-7-yl)urea;CXCR,nonpeptide,inhibit,Inhibitor,SB-265610,inflammation,recruitment,Delay,SB 265610,healing,neutrophil,SB265610,wound,CXC chemokine receptors
- CBNumber:
- CB71872298
- Molecular Formula:
- C14H9BrN6O
- Molecular Weight:
- 357.16
- MDL Number:
- MFCD09971124
- MOL File:
- 211096-49-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| SB265610 ≥98% (HPLC) | SML0421 | 5mg | $176 |
| SB265610 ≥98% (HPLC) | SML0421 | 25mg | $707 |
| SB 265610 ≥98% | 17879 | 1mg | $107 |
| SB 265610 ≥98% | 17879 | 5mg | $143 |
| SB 265610 ≥98% | 17879 | 10mg | $246 |
| Boiling point | 527.0±45.0 °C(Predicted) |
|---|---|
| Density | 1.77±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble15mg/mL, clear |
| form | powder |
| pka | 6.13±0.40(Predicted) |
| color | white to light brown |
| InChI | 1S/C14H9BrN6O/c15-9-3-1-2-4-10(9)17-14(22)18-11-6-5-8(7-16)12-13(11)20-21-19-12/h1-6H,(H2,17,18,22)(H,19,20,21) |
| InChIKey | SEDUMQWZEOMXSO-UHFFFAOYSA-N |
| SMILES | Brc1ccccc1NC(=O)Nc2ccc(C#N)c3nn[nH]c23 |
| FDA UNII | 9P785F0579 |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral |
GSK-CXCR2 price More Price(70)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0421 | SB265610 ≥98% (HPLC) | 211096-49-0 | 5mg | $176 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML0421 | SB265610 ≥98% (HPLC) | 211096-49-0 | 25mg | $707 | 2026-04-30 | Buy |
| Cayman Chemical | 17879 | SB 265610 ≥98% | 211096-49-0 | 1mg | $107 | 2026-04-30 | Buy |
| Cayman Chemical | 17879 | SB 265610 ≥98% | 211096-49-0 | 5mg | $143 | 2026-04-30 | Buy |
| Cayman Chemical | 17879 | SB 265610 ≥98% | 211096-49-0 | 10mg | $246 | 2026-04-30 | Buy |
GSK-CXCR2 Chemical Properties,Uses,Production
Uses
SB 265610 is an anti-tumor pharmaceutical developed to act as an antagonist to cysteine-amino acid-cysteine (CXC) chemokines receptor 2 antagonist.
Biological Activity
Potent CXCR2 antagonist that inhibits CINC-1-mediated but not C5a-mediated Ca 2+ mobilization (IC 50 values are 3.4 and 6800 nM respectively). Inhibits CINC-induced chemotaxis and attenuates neutrophil accumulation in inflammatory lung injury in vivo .
Biochem/physiol Actions
SB265610 is a potent and selective CXCR2 chemokine receptor antagonist. It has a Kd = 2.5 nM.
in vivo
SB-265610 (2 mg/kg/day; i.p.; daily; for two weeks) treatment significantly inhibits the recruitment of Gr-1+CD11b+ cells to the mammary adenocarcinoma with Tgfbr2 deletion but not the control tumors[3].
| Animal Model: | MMTV-PyVmT/Tgfbr2MGKO and MMTV-PyVmT/Tgfbr2flox/flox tumors from donor mice[3] |
| Dosage: | 2 mg/kg/day |
| Administration: | Intraperitoneal injection; daily; for two weeks |
| Result: | Significantly inhibited the recruitment of Gr-1+CD11b+ cells to the mammary adenocarcinoma. |
IC 50
CXCR2
storage
Store at RT
GSK-CXCR2 Preparation Products And Raw materials
Raw materials
Preparation Products
GSK-CXCR2 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| Aromsyn Co., Ltd. | +86-0571-85585865 +8613336024896 | CB@aromsyn.com | China | 19183 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15838 | 69 |
| Bide Pharmatech Ltd. | 400-400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| AdooQ Bioscience CHINA | 025-58849295 18951903616; | info@adooq.cn | China | 2990 | 60 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51395 | 80 |
