Methyl Benzimidazole-5-carboxylate
- CAS No.
- 26663-77-4
- Chemical Name:
- Methyl Benzimidazole-5-carboxylate
- Synonyms
- methyl 1H-benzo[d]imidazole-5-carboxylate;methyl 1H-benzo[d]imidazole-6-carboxylate;1H-Benzimidazole-5-carboxylic acid methyl ester;AKOS BBS-00000245;Benzimidazole-5-methyl formate;5-(Methoxycarbonyl)benziMidazole;Methyl 5-BenziMidazolecarboxylate;METHYL BENZIMIDAZOLE-5-CARBOXYLATE;MethylBenzimidazole-5-carboxylate>METHYL 1H-BENZIMIDAZOLE-5-CARBOXYLATE
- CBNumber:
- CB7188457
- Molecular Formula:
- C9H8N2O2
- Molecular Weight:
- 176.17
- MDL Number:
- MFCD03407310
- MOL File:
- 26663-77-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Methyl Benzimidazole-5-carboxylate >98.0%(GC)(T) | M2582 | 1g | $96 |
| 1H-BENZIMIDAZOLE-5-CARBOXYLICACIDMETHYLESTER 97% | CL3438 | 5G | $17 |
| 1H-BENZIMIDAZOLE-5-CARBOXYLICACIDMETHYLESTER 97% | CL3438 | 25G | $67 |
| Methyl 1H-benzimidazole-5-carboxylate ≥95% | OR25948 | 1g | $21 |
| Methyl 1H-benzimidazole-5-carboxylate ≥95% | OR25948 | 5g | $29 |
| More product size | |||
| Melting point | 139 °C |
|---|---|
| Boiling point | 416.2±18.0 °C(Predicted) |
| Density | 1.324±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| form | powder to crystal |
| pka | 11.67±0.10(Predicted) |
| color | White to Light yellow to Light orange |
| InChI | InChI=1S/C9H8N2O2/c1-13-9(12)6-2-3-7-8(4-6)11-5-10-7/h2-5H,1H3,(H,10,11) |
| InChIKey | WJHHIVYNOVTVGY-UHFFFAOYSA-N |
| SMILES | C1NC2=CC(C(OC)=O)=CC=C2N=1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H335-H315 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
| Hazard Codes | Xi |
| Hazard Note | Irritant |
| HS Code | 2933998090 |
Methyl Benzimidazole-5-carboxylate price More Price(71)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M2582 | Methyl Benzimidazole-5-carboxylate >98.0%(GC)(T) | 26663-77-4 | 1g | $96 | 2026-04-30 | Buy |
| AstaTech | CL3438 | 1H-BENZIMIDAZOLE-5-CARBOXYLICACIDMETHYLESTER 97% | 26663-77-4 | 5G | $17 | 2026-04-30 | Buy |
| AstaTech | CL3438 | 1H-BENZIMIDAZOLE-5-CARBOXYLICACIDMETHYLESTER 97% | 26663-77-4 | 25G | $67 | 2026-04-30 | Buy |
| Apolloscientific | OR25948 | Methyl 1H-benzimidazole-5-carboxylate ≥95% | 26663-77-4 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR25948 | Methyl 1H-benzimidazole-5-carboxylate ≥95% | 26663-77-4 | 5g | $29 | 2026-06-04 | Buy |
Methyl Benzimidazole-5-carboxylate Chemical Properties,Uses,Production
Uses
Methyl Benzimidazole-5-carboxylate can be used as an intermediate used for the synthesis of a number of bioisosteric benzimidazoles as inhibitors of human cytosolic phospholipase A2α.
Synthesis
67-56-1
15788-16-6
26663-77-4
General procedure for the synthesis of methyl benzimidazole-5-carboxylate from methanol and 1H-benzimidazole-5-carboxylic acid: (a) Synthesis of methyl 1H-benzimidazole-5-carboxylate Thionyl chloride (0.135 mL, 1.85 mmol) was slowly added dropwise to a solution of 1H-benzimidazole-5-carboxylic acid (0.300 g, 1.85 mmol) in methanol (50.0 mL). The reaction mixture was refluxed for 12 hours. After completion of the reaction, the mixture was poured into saturated aqueous sodium bicarbonate solution and stirred thoroughly. The organic layer was separated and the aqueous layer was extracted with ethyl acetate (3 x 15 mL). The organic layers were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give a purple solid product in 90% yield. The crude product can be used in subsequent reactions without further purification. [MS (ES+) m/e 177 [M + H]+].
References
[1] Patent: WO2005/82901, 2005, A1. Location in patent: Page/Page column 91
[2] Patent: WO2013/26914, 2013, A1. Location in patent: Page/Page column 125
[3] Patent: WO2007/103755, 2007, A2. Location in patent: Page/Page column 111
[4] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 20, p. 2925 - 2930
[5] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 24, p. 3161 - 3164
Methyl Benzimidazole-5-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 9542 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Shanxi Xuanran Import and Export Trade Co., Ltd. | +8617735180244 | mike_yan@xuanranglobal.com | CHINA | 4017 | 58 |
| Chemsigma International Co., Ltd. | +86-2558742998 +86-19951791336 | info@chemsigma.com | China | 1807 | 58 |
View Lastest Price from Methyl Benzimidazole-5-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-31 | Methyl Benzimidazole-5-carboxylate
26663-77-4
|
$1.00 | 1KG | 99% | 1000KGS | Career Henan Chemical Co |
-
- Methyl Benzimidazole-5-carboxylate
26663-77-4
- $1.00
- 99%
- Career Henan Chemical Co
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