2-Methylanisole
- CAS No.
- 578-58-5
- Chemical Name:
- 2-Methylanisole
- Synonyms
- FEMA 2680;2-Methylanisol;o-Methylanisol;O-METHYLANISOLE;2-METHYLANISOLE;o-Methoxytoluene;2-METHOXYTOLUENE;Anisole, o-methyl-;ORTHO-METHYLANISOLE;2-Methoxytoluene>
- CBNumber:
- CB7194957
- Molecular Formula:
- C8H10O
- Molecular Weight:
- 122.16
- MDL Number:
- MFCD00008373
- MOL File:
- 578-58-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-Methylanisole ≥99%, FG | W268003 | 1 each | $55.9 |
| 2-Methylanisole ≥99%, FG | W268003 | 100g | $103 |
| 2-Methylanisole ≥99%, FG | W268003 | 1kg | $496 |
| 2-Methylanisole ≥99%, FG | W268003 | 5kg | $1790 |
| 2-Methylanisole 99% | M29355 | 100ml | $108 |
| More product size | |||
| Melting point | -34.1°C |
|---|---|
| Boiling point | 170-172 °C (lit.) |
| Density | 0.985 g/mL at 25 °C (lit.) |
| vapor pressure | 2hPa at 25℃ |
| refractive index |
n |
| FEMA | 2680 | O-METHYLANISOLE |
| FLAVIS Number | 04.014 | 1-Methoxy-2-methylbenzene |
| Flash point | 125 °F |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform, Ethyl Acetate (Slightly) |
| form | Liquid |
| color | Clear colorless to light yellow |
| Specific Gravity | 0.985 |
| Odor | at 1.00 % in dipropylene glycol. sweet nutty floral earthy walnut |
| Odor Threshold | 0.0029ppm |
| Odor Type | naphthyl |
| Viscosity | 14.678mm2/s |
| biological source | synthetic |
| Water Solubility | immiscible |
| JECFA Number | 1242 |
| BRN | 1857415 |
| Dielectric constant | 3.5699999999999998 |
| InChI | 1S/C8H10O/c1-7-5-3-4-6-8(7)9-2/h3-6H,1-2H3 |
| InChIKey | DTFKRVXLBCAIOZ-UHFFFAOYSA-N |
| SMILES | COc1ccccc1C |
| LogP | 3 at 25℃ |
| CAS DataBase Reference | 578-58-5(CAS DataBase Reference) |
| Substances Added to Food (formerly EAFUS) | O-METHYLANISOLE |
| FDA UNII | 09G73SL17K |
| NIST Chemistry Reference | Benzene, 1-methoxy-2-methyl-(578-58-5) |
| EPA Substance Registry System | Benzene, 1-methoxy-2-methyl- (578-58-5) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS02 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H226 | |||||||||
| Precautionary statements | P210-P233-P240-P241+P242+P243-P280-P303+P361+P353-P370+P378-P403+P235-P501-P261 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | F | |||||||||
| Risk Statements | 10 | |||||||||
| Safety Statements | 16 | |||||||||
| RIDADR | UN 1993 3/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Flammable | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29093090 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Flam. Liq. 3 | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
2-Methylanisole price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | W268003 | 2-Methylanisole ≥99%, FG | 578-58-5 | 1 each | $55.9 | 2026-03-19 | Buy |
| Sigma-Aldrich | W268003 | 2-Methylanisole ≥99%, FG | 578-58-5 | 100g | $103 | 2026-03-19 | Buy |
| Sigma-Aldrich | W268003 | 2-Methylanisole ≥99%, FG | 578-58-5 | 1kg | $496 | 2026-03-19 | Buy |
| Sigma-Aldrich | W268003 | 2-Methylanisole ≥99%, FG | 578-58-5 | 5kg | $1790 | 2026-03-19 | Buy |
| Sigma-Aldrich | M29355 | 2-Methylanisole 99% | 578-58-5 | 100ml | $108 | 2026-03-19 | Buy |
2-Methylanisole Chemical Properties,Uses,Production
Chemical Properties
o-Methylanisole has a pungent, warm, floral odor with earthy, walnut undertones. It has a sweet, fruity, nut-like flavor at low levels.
Physical properties
clear colorless to light yellow liquid. soluble in alcohol and ether, insoluble in water.
Occurrence
Reported found in starfruit, mastic gum oil and rooibus tea (Aspalathus linearis).
Uses
The catalytic system of disubstituted aromatics was optimized for the 2-methylanisole reduction by a proper choice of the amine/Rh ratio which should be high enough to stabilize very small colloidal rhodium particles and low enough to avoid deactivation. The total synthesis of (±)-heliannuol D and its epimer has been completed in 9 steps and 12% overall yield from 2-methylanisole. The thermal activation of 2-methylanisole (60°C) by the Ir (III) complex TpMe2Ir (C6H5) 2 (N2)(1; TpMe2= hydrotris (3, 5-dimethylpyrazolyl) borate) yielded a mixture of hydride complexes. The total synthesis of the phenolic sesquiterpene mutisianthol has been accomplished in 12 steps from the readily available 2-methylanisole. The catalytic system was optimized for the 2-methylanisole reduction by a proper choice of the amine/Rh ratio which should be high enough to stabilize very small colloidal rhodium particles and low enough to avoid deactivation.
Definition
ChEBI: 2-methylanisole is a monomethoxybenzene that is o-cresol in which phenolic hydroxy group has been converted to the corresponding methyl ether. A 'green' solvent (b.p. 171°C) and food flavour ingredient, it is found in mastic oils, virgin olive oils and frankincense. It has a role as a polar aprotic solvent and a flavouring agent. It is a monomethoxybenzene, a volatile organic compound and a member of toluenes. It derives from an o-cresol.
Preparation
2-Methylanisole is synthesized by methylation of o-cresol using dimethylsulfate in caustic soda at 40°C.
synthesis of 2-methylanisole: Make sodium hydroxide into a 20% solution, stir and mix with o-cresol, cool to below 10°C, and slowly add dimethyl sulfate dropwise. After the addition was completed, the temperature was raised to 40 °C for 20 min, and then reacted with 100 °C for 12 h. Then the reactant was washed with water until neutral, water was removed, distilled, and the fraction at 171°C was collected to obtain the finished product of 2-methylanisole.
Aroma threshold values
Detection: 600 ppb. Aroma characteristics at 1.0%: naphthyl, camphoreous, phenolic and woody with a salicylate nuance.
Taste threshold values
Taste characteristics at 5.0 ppm: camphoreous, earthy, woody and alicylate with minty, spicy nuances.
General Description
2-Methylanisole is found in mastic oils, virgin olive oils and frankincense. It is a monomethoxybenzene and acts as an intermediate for the preparation of compounds with methylhydroquinone core.
Flammability and Explosibility
Flammable
2-Methylanisole Preparation Products And Raw materials
Raw materials
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Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5235 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3692 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13815 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21591 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29820 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 +86-17392581500 | 1015@dideu.com | China | 3992 | 58 |
View Lastest Price from 2-Methylanisole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-22 | 2-Methylanisole
578-58-5
|
US $29.00 / mL | 99.79% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-03-20 | 2-Methylanisole
578-58-5
|
US $10.00 / KG | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-05-26 | 2-Methylanisole
578-58-5
|
US $10.00 / KG | 1KG | 99% | 10 ton | Hebei Chuanghai Biotechnology Co,.LTD |
-
- 2-Methylanisole
578-58-5
- US $29.00 / mL
- 99.79%
- TargetMol Chemicals Inc.
-
- 2-Methylanisole
578-58-5
- US $10.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 2-Methylanisole
578-58-5
- US $10.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
