2-Chloropyridine-5-carbaldehyde
- CAS No.
- 23100-12-1
- Chemical Name:
- 2-Chloropyridine-5-carbaldehyde
- Synonyms
- 6-CHLORONICOTINALDEHYDE;6-CHLORO-PYRIDINE-3-CARBALDEHYDE;TIMTEC-BB SBB004157;2-Chloropyridine-5-c;oropyridine-5-carbaL;6-Chloronicotildehyde;2-CHLORO-5-FORMYLPYRIDINE;6-Chloronicotinaldehyde 97%;6-CHLORO-PYRIDIN-3-CARBALDEHYDE;2-CHLOROPYRIDINE-5-CARBALDEHYDE
- CBNumber:
- CB7205204
- Molecular Formula:
- C6H4ClNO
- Molecular Weight:
- 141.56
- MDL Number:
- MFCD03095223
- MOL File:
- 23100-12-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 6-Chloropyridine-3-carboxaldehyde 96% | 596175 | 1g | $39.9 |
| 6-Chloropyridine-3-carboxaldehyde 96% | 596175 | 5g | $144 |
| 6-Chloro-3-pyridinecarboxaldehyde >96.0%(GC) | C2519 | 1g | $44 |
| 6-Chloro-3-pyridinecarboxaldehyde >96.0%(GC) | C2519 | 5g | $136 |
| 6-Chloronicotinaldehyde | C380528 | 100mg | $75 |
| More product size | |||
| Melting point | 77-81 °C(lit.) |
|---|---|
| Boiling point | 117-119 °C(Press: 5 Torr) |
| Density | 1.332±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | -1.85±0.10(Predicted) |
| form | Crystalline Powder |
| color | White to yellow |
| Water Solubility | Soluble in water. |
| InChI | InChI=1S/C6H4ClNO/c7-6-2-1-5(4-9)3-8-6/h1-4H |
| InChIKey | AFWWKZCPPRPDQK-UHFFFAOYSA-N |
| SMILES | C1=NC(Cl)=CC=C1C=O |
| CAS DataBase Reference | 23100-12-1(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
2-Chloropyridine-5-carbaldehyde price More Price(49)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 596175 | 6-Chloropyridine-3-carboxaldehyde 96% | 23100-12-1 | 1g | $39.9 | 2023-06-20 | Buy |
| Sigma-Aldrich | 596175 | 6-Chloropyridine-3-carboxaldehyde 96% | 23100-12-1 | 5g | $144 | 2023-06-20 | Buy |
| TCI Chemical | C2519 | 6-Chloro-3-pyridinecarboxaldehyde >96.0%(GC) | 23100-12-1 | 1g | $44 | 2025-07-31 | Buy |
| TCI Chemical | C2519 | 6-Chloro-3-pyridinecarboxaldehyde >96.0%(GC) | 23100-12-1 | 5g | $136 | 2025-07-31 | Buy |
| TRC | C380528 | 6-Chloronicotinaldehyde | 23100-12-1 | 100mg | $75 | 2021-12-16 | Buy |
2-Chloropyridine-5-carbaldehyde Chemical Properties,Uses,Production
Chemical Properties
Off-white crystal
Uses
2-Chloropyridine-5-carboxaldehyde is used as pharmaceutical intermediates
Synthesis
21543-49-7
23100-12-1
The general procedure for the synthesis of 6-chloropyridine-3-carbaldehyde according to Lee et al. was as follows: oxalyl chloride (3.81 g, 30.0 mmol, 3.0 equiv.) was dissolved in dry dichloromethane (35 mL) at -78 °C (dry ice/acetone bath). Dimethyl sulfoxide (DMSO, 46.9 g, 0.60 mol, 60.0 eq.) was slowly added dropwise under stirring and stirring was continued for 30 min at -78 °C. Subsequently, 2-chloro-5-hydroxymethylpyridine (1.44 g, 10.0 mmol, 1.00 eq.) was dissolved in dichloromethane (10 mL) and added slowly dropwise via syringe to the cooled reaction mixture. After the reaction mixture was stirred at -78 °C for 40 min, triethylamine (NEt3, 91.9 g, 0.90 mol, 90.0 eq.) was added at a rate of 2.0 mL/min. Stirring was continued at -78 °C for 1 hour, then brought to room temperature and stirred for 1.5 hours. After completion of the reaction, the reaction mixture was diluted with ether (60 mL) and the organic phase was washed sequentially with saturated aqueous sodium bicarbonate (2 x 30 mL), 1M aqueous potassium bisulfate (60 mL) and saturated aqueous sodium bicarbonate (30 mL). After separation of the organic phase, it was dried with anhydrous sodium sulfate, filtered to remove solids, and concentrated under reduced pressure to remove solvent. Finally, it was purified by silica gel column chromatography (n-pentane/ethyl acetate/triethylamine=200/100/6) to afford the light yellow solid product 6-chloropyridine-3-carbaldehyde (1.35 g, 96% yield).
References
[1] Chemical Communications, 1999, # 18, p. 1907 - 1908
[2] Organic Letters, 2005, vol. 7, # 14, p. 2965 - 2967
[3] Electrochimica Acta, 2014, vol. 140, p. 101 - 107
[4] Chemistry - A European Journal, 2016, vol. 22, # 15, p. 5319 - 5326
[5] Journal of the Chemical Society - Perkin Transactions 1, 1999, # 10, p. 1253 - 1255
2-Chloropyridine-5-carbaldehyde Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20128 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 880 | 50 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13799 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21597 | 55 |
| Zjartschem | +86-571 87238903 | jocelynpan@zjarts.com | CHINA | 988 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29831 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
View Lastest Price from 2-Chloropyridine-5-carbaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-01 | 2-Chloropyridine-5-carbaldehyde
23100-12-1
|
US $0.00 / kg | 1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | |
 |
2025-09-25 | 6-Chloronicotinaldehyde
23100-12-1
|
US $8.00-0.80 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2025-04-04 | 2-Chloropyridine-5-carbaldehyde
23100-12-1
|
US $0.00-0.00 / KG | 1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. |
-
- 2-Chloropyridine-5-carbaldehyde
23100-12-1
- US $0.00 / kg
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- 6-Chloronicotinaldehyde
23100-12-1
- US $8.00-0.80 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 2-Chloropyridine-5-carbaldehyde
23100-12-1
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.
