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2-Bromo-4-trifluoromethoxyaniline

2-Bromo-4-trifluoromethoxyaniline Structure
2-Bromo-4-trifluoromethoxyaniline structure
CAS No.
175278-17-8
Chemical Name:
2-Bromo-4-trifluoromethoxyaniline
Synonyms
2-BROMO-4-(TRIFLUOROMETHOXY)ANILINE;BUTTPARK 83\07-26;2-Bromo-4-trifluorom;Liraglutide Impurity 05;Fluoroestradiol Impurity 28;2-Bromo-4-(trifluoeomethoxy)aniline;2-Bromo-4-(trifluoromethoxy)aniline98%;2-Bromo-4-(trifluoromethoxy)aniline 98%;2-Bromo-4-(trifluoromethoxy)aniline >Benzenamine, 2-bromo-4-(trifluoromethoxy)-
CBNumber:
CB7210237
Molecular Formula:
C7H5BrF3NO
Molecular Weight:
256.02
MDL Number:
MFCD00203478
MOL File:
175278-17-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-24 14:59:05
Product description Number Pack Size Price
2-Bromo-4-(trifluoromethoxy)aniline 98% 457388 10g $23.7
2-Bromo-4-(trifluoromethoxy)aniline >98.0%(GC) B3799 5g $41
2-Bromo-4-(trifluoromethoxy)aniline >98.0%(GC) B3799 25g $131
2-Bromo-4-(trifluoromethoxy)aniline ≥98%(GC) 45977 5G $61.8
2-Bromo-4-(trifluoromethoxy)aniline ≥98%(GC) 45977 25G $234.1
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2-Bromo-4-trifluoromethoxyaniline Properties

Boiling point 209 °C(lit.)
Density 1.693 g/mL at 25 °C(lit.)
refractive index n20/D 1.504(lit.)
Flash point >230 °F
storage temp. Keep in dark place,Inert atmosphere,Room temperature
pka 1.68±0.10(Predicted)
form Liquid
color Clear light yellow to orange-yellow
Specific Gravity 1.693
InChI InChI=1S/C7H5BrF3NO/c8-5-3-4(1-2-6(5)12)13-7(9,10)11/h1-3H,12H2
InChIKey ROSTYHNIIDIBEG-UHFFFAOYSA-N
SMILES C1(N)=CC=C(OC(F)(F)F)C=C1Br
CAS DataBase Reference 175278-17-8(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xi,T
Risk Statements  36/37/38
Safety Statements  26-36-37/39
WGK Germany  3
Hazard Note  Toxic
HazardClass  IRRITANT
HS Code  29222990
Storage Class 10 - Combustible liquids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
0 0

2-Bromo-4-trifluoromethoxyaniline price More Price(45)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 457388 2-Bromo-4-(trifluoromethoxy)aniline 98% 175278-17-8 10g $23.7 2026-04-30 Buy
TCI Chemical B3799 2-Bromo-4-(trifluoromethoxy)aniline >98.0%(GC) 175278-17-8 5g $41 2026-04-30 Buy
TCI Chemical B3799 2-Bromo-4-(trifluoromethoxy)aniline >98.0%(GC) 175278-17-8 25g $131 2026-04-30 Buy
Chem-Impex 45977 2-Bromo-4-(trifluoromethoxy)aniline ≥98%(GC) 175278-17-8 5G $61.8 2026-05-19 Buy
Chem-Impex 45977 2-Bromo-4-(trifluoromethoxy)aniline ≥98%(GC) 175278-17-8 25G $234.1 2026-05-19 Buy
Product number Packaging Price Buy
457388 10g $23.7 Buy
B3799 5g $41 Buy
B3799 25g $131 Buy
45977 5G $61.8 Buy
45977 25G $234.1 Buy

2-Bromo-4-trifluoromethoxyaniline Chemical Properties,Uses,Production

Chemical Properties

clear light yellow to orange-yellow liquid

Synthesis

4-(Trifluoromethoxy)aniline

461-82-5

2-Bromo-4-trifluoromethoxyaniline

175278-17-8

General procedure for the synthesis of 2-bromo-4-trifluoromethoxyaniline from 4-(trifluoromethoxy)aniline: N-bromosuccinimide (3.62 g, 20.34 mmol) was slowly added to a solution of 4-(trifluoromethoxy)aniline (3.00 g, 16.9 mmol) in acetonitrile (30 mL) at 0 °C. The reaction mixture was gradually warmed to room temperature and stirred continuously for 4 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure to give the crude product. The crude product was purified by column chromatography using 10% ethyl acetate/hexane as eluent to give 2-bromo-4-trifluoromethoxyaniline as a brown oil (3.6 g, 83% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 4.11 (broad single peak, 2H), 6.73 (double peak, 1H), 6.99 (double-double-heavy peak, 1H), and 7.31 (double-heavy peak, 1H).The LC-MS analysis showed that the [M-H]- peak was located at m/z 253.1.

References

[1] Patent: WO2015/100232, 2015, A2. Location in patent: Page/Page column 102
[2] Journal of Medicinal Chemistry, 2007, vol. 50, # 1, p. 113 - 128
[3] Patent: EP1183229, 2005, B1. Location in patent: Page/Page column 143-144
[4] Organic Letters, 2011, vol. 13, # 20, p. 5636 - 5639
[5] Journal of the American Chemical Society, 2016, vol. 138, # 40, p. 13147 - 13150

2-Bromo-4-trifluoromethoxyaniline Preparation Products And Raw materials

Raw materials

4-(Trifluoromethoxy)aniline N-BROMO SUCCINAMIDE Acetonitrile

Preparation Products

2-Amino-5-(trifluoromethoxy)biphenyl

2-Bromo-4-trifluoromethoxyaniline Suppliers

Global( 261)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20124 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29640 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29816 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Wuhan Chemwish Technology Co., Ltd 		027-67849912 sales@chemwish.com CHINA 10821 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49977 58
Richest Group Ltd 		18017061086 oled@richest-group.com CHINA 5600 58
Fuxin Pharmaceutical 		+86-021-021-50872116 +8613122107989 contact@fuxinpharm.com China 10000 58
Antai Fine Chemical Technology Co.,Limited 		18503026267 info@antaichem.com CHINA 9636 58
Supplier Advantage
Henan Fengda Chemical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Alchem Pharmtech,Inc. 		58
Wuhan Chemwish Technology Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
Richest Group Ltd 		58
Fuxin Pharmaceutical 		58
Antai Fine Chemical Technology Co.,Limited 		58

View Lastest Price from 2-Bromo-4-trifluoromethoxyaniline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Bromo-4-trifluoromethoxyaniline pictures 2025-11-18 2-Bromo-4-trifluoromethoxyaniline
175278-17-8
 US $1.10 / g 1g 99.00% 100 Tons Min Dideu Industries Group Limited
2-Bromo-4-(trifluoromethoxy)aniline pictures 2025-09-25 2-Bromo-4-(trifluoromethoxy)aniline
175278-17-8
 US $8.00-0.80 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
2-Bromo-4-trifluoromethoxyaniline pictures 2019-07-12 2-Bromo-4-trifluoromethoxyaniline
175278-17-8
 US $1.00 / KG 1KG 99% 100kg Career Henan Chemical Co

2-Bromo-4-trifluoromethoxyaniline Spectrum

2-Bromo-4-trifluoromethoxyaniline(175278-17-8)1HNMR2-Bromo-4-trifluoromethoxyaniline(175278-17-8)IR

175278-17-8(2-Bromo-4-trifluoromethoxyaniline)Related Search:

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2-Bromo-4-(trifluoromethoxy)aniline 98% 2-Bromo-4-(trifluoromethoxy)aniline98% 2-BROMO-4-(TRIFLUOROMETHOXY)ANILINE BUTTPARK 83\07-26 2-Bromo-4-(trifluoeomethoxy)aniline 2-Bromo-4-trifluorom 2-Bromo-4-(trifluoromethoxy)aniline > Benzenamine, 2-bromo-4-(trifluoromethoxy)- 2-Bromo-4-trifluoromethoxyaniline ISO 9001：2015 REACH Fluoroestradiol Impurity 28 Liraglutide Impurity 05 175278-17-8 75278-17-8 BrC6H3OCF3NH2 C7H5NOBrF3 Nitrogen Compounds Organic Building Blocks Amines Building Blocks C7 Building Blocks Chemical Synthesis Nitrogen Compounds Organic Building Blocks Fluorine series amine| alkyl bromide blocks Bromides FluoroCompounds NitroCompounds Anilines, Aromatic Amines and Nitro Compounds Amines C7 Nitrogen Compounds