ChemicalBook >> CAS DataBase List >>9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
- CAS No.
- 981-34-0
- Chemical Name:
- 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
- Synonyms
- DB11;(9β,11β,16β)-;Einecs 213-563-4;16β Methyl Epoxide;9beta,11beta-Epoxy-1;11beta-Epoxy-17alpha;Betamethasone epoxide;16-beta Methyl Epoxid;16-BETA METHYL EPOXIDE;DB11(16β-Methyl Epoide)
- CBNumber:
- CB72129663
- Molecular Formula:
- C22H28O5
- Molecular Weight:
- 372.45
- MDL Number:
- MFCD09038712
- MOL File:
- 981-34-0.mol
- MSDS File:
- SDS
Last updated:2026-01-13 11:24:11
| Product description | Number | Pack Size | Price |
| 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione | E589175 | 250mg | $95 |
| 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione | E589175 | 2g | $160 |
| Betamethasone 9,11-epoxide | 262572 | 1g | $360 |
| Betamethasone 9,11-epoxide | FB18569 | 50g | $450 |
| Betamethasone 9,11-epoxide | FB18569 | 25g | $250 |
| More product size | |||
| Melting point | 210-220 ºC |
|---|---|
| Boiling point | 564.9±50.0 °C(Predicted) |
| Density | 1.32±0.1 g/cm3(Predicted) |
| vapor pressure | 0-357.304Pa at 25℃ |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly, Heated), Dioxane (Slightly, Heated), DMSO (Slightly, Heated) |
| pka | 12.56±0.70(Predicted) |
| form | Solid |
| color | White to Light Beige |
| Major Application | pharmaceutical small molecule |
| InChIKey | GBDXNHBVYAMODG-OBDZOPJXNA-N |
| SMILES | C[C@]12C=CC(=O)C=C1CC[C@@]1([H])[C@]3([H])C[C@H](C)[C@](O)(C(=O)CO)[C@@]3(C)C[C@@H]3O[C@]213 |&1:1,10,12,15,17,23,26,28,r| |
| FDA UNII | M9AY9BSI41 |
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | E589175 | 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione | 981-34-0 | 250mg | $95 | 2021-12-16 | Buy |
| TRC | E589175 | 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione | 981-34-0 | 2g | $160 | 2021-12-16 | Buy |
| Usbiological | 262572 | Betamethasone 9,11-epoxide | 981-34-0 | 1g | $360 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB18569 | Betamethasone 9,11-epoxide | 981-34-0 | 50g | $450 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB18569 | Betamethasone 9,11-epoxide | 981-34-0 | 25g | $250 | 2021-12-16 | Buy |
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Chemical Properties,Uses,Production
Description
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione (Betamethasone EP Impurity E) is a metabolite of Mometasone Furoate (M490000) which is a tropical corticosteroid used as an anti-inflammatory. Low solubility in most solvent. 9,11β-epoxysteroid compounds can be prepared by 9-position fluorination to obtain dexamethasone. By modifying its 3-bit, 6-bit, 16-bit, and 21-bit, a series of drugs can be prepared.
Chemical Properties
Off-White Solid
Uses
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione is a metabolite of Mometasone furoate. It has low solubility in most solvents.
Preparation
Add sodium sulfite and sodium hydroxide to water, stir to dissolve, and then add methanol. The raw material was added for hydrolysis reaction. After the reaction for 3h, glacial acetic acid was added to adjust the pH=6~8. The water was added to the solution and crystallize at 0 ℃. Finally, 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione was obtained after purification.
Toxics Screening Level
The initial threshold screening level (ITSL) for betamethasone 11 is 17 μg/m3 based on an annual averaging time.
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 238)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Shizhou Biotechnology Co., Ltd | +86-15850508050 | sean.lv@synzest.com | China | 323 | 58 |
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | admin@guyunchem.com | China | 615 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21595 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29830 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6369 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Hebei shuoxi biotechnology co. LTD | +8613081092107 | CHINA | 964 | 58 | |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5742 | 58 |
View Lastest Price from 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-07-31 | 11beta-Epoxy-17alpha
981-34-0
|
US $0.10 / kg | 10kg | 99% | 5000kg | Hebei Linwo New Material Technology Co., LTD | |
 |
2023-07-27 | DB11
981-34-0
|
US $1.50 / g | 1g | 99.0% Min | 100 Tons | Shaanxi Didu New Materials Co. Ltd | |
 |
2023-03-12 | 9beta,11beta-Epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione
981-34-0
|
US $0.00 / kg | 1kg | 98.0%min | 100kg | LY Global chemicals co.,ltd . |
-
- 11beta-Epoxy-17alpha
981-34-0
- US $0.10 / kg
- 99%
- Hebei Linwo New Material Technology Co., LTD
-
- DB11
981-34-0
- US $1.50 / g
- 99.0% Min
- Shaanxi Didu New Materials Co. Ltd
-
- 9beta,11beta-Epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione
981-34-0
- US $0.00 / kg
- 98.0%min
- LY Global chemicals co.,ltd .
981-34-0(9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione )Related Search:
16-BETA METHYL EPOXIDE
9beta,11beta-epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione
DB11
(9β)-9,11β-Epoxy-16β-methyl-17,21-dihydroxypregna-1,4-diene-3,20-dione
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
Einecs 213-563-4
Betamethasone 9,11-Epoxide
(9β,11β,16β)-
9beta,11beta-Epoxy-1
DB11(16B-Methyl Epoide)
DB11(16β-Methyl Epoide)
(4aS,4bS,5aS,6aS,7R,8S,9aS,9bS)-7-Hydroxy-7-(2-hydroxyacetyl)-4a,6a,8-triMethyl-5a,6,6a,7,8,9,9a,9b,10,11-decahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-2(4aH)-one
Betamethasone epoxide
(4aS,4bS,5aS,6aS,7R,9aS,9bS)-7-Hydroxy-7-(2-hydroxyacetyl)-4a,6a-Dimethyl-8-methylene-5a,6,6a,7,8,9,9a,9b,10,11-decahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-2(4aH)-one
Pregna-1,4-diene-3,20-dione,9
17α,21-dihydroxy-9β,11β-epoxy-16β-methylpregna-1,4-diene-3,20-dione
Beclomethasone EP Impurity R
Betamethasone Impurity 5（Betamethasone EP Impurity E）
Beclometasone Dipropionate?EP Impurity R
16-beta Methyl Epoxid
9,11beta-Epoxy-17,21-dihydroxy-16be
9Beta,11beta-Epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione[DB11]
Pregna-1,4-diene-3,20-dione, 9,11-epoxy-17,21-dihydroxy-16-methyl-, (9β,11β,16β)-
Beclomethasone Impurity 6
Beta,11beta-Epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione
Beclomethasone propionate EP impurity R
Beclomethasone Impurity 15(Beclometasone Dipropionate EP Impurity R)
9-beta,11-beta-epoxy-17-alpha,21-dihydroxy-16-beta-methylene...
DB11(16β-Methyl Epoxide)
11beta-Epoxy-17alpha
9,11β-Epoxy-17,21-dihydroxy-16β-methyl-9β-pregna-1,4-diene-3,20-dione
Beclomethasone dipropionate EP Impurity R
9-β,11-β-epoxy-17-α,21-dihydroxy-16-beta-methylenepregna-1,4-diene-3,20-dione
Beclometasone Propionate EP Impurity R
Beclometasone Dipropionate Impurity R
Betamethasone Impurity E
Beclometasone Propionate EP Impurity R（Betamethasone EP Impurity E）
Betamethasone 9,11-Epoxide (Beclomethasone Dipropionate EP Impurity R)
Beclomethasone Dipropionate EP Impurity R (Betamethasone 9,11-Epoxide)
Betamethasone epoxy hydrolysate
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregnα-1,4-diene-3,20-dione
9beta,11beta-Epoxy-17alpha,21-dihydroxy-16beta-met
93.113-Epoxy-17a,21-dihydroxy-16p
-methylenepregna-1.4-diene-3.20-dione(DB11)
(9β,11β,16β)-9,11-Epoxy-17,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
Betamethasone epoxide hydrolase
Beclometasone Dipropionate EP Impurity R (Betamethasone 9,11-Epoxide)
Beclometasone Impurity R
9,11beta-Epoxy-17,21-dihydroxy-16beta-methyl-9beta-pregna-1,4-diene-3,20-dione
Betamethasone Epoxide Hydrolyzate
Beclomethasone Propionate intermediate
DB Xl - 9beta,11beta-Epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione
16β Methyl Epoxide
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
Betamethasone 9,11-Epoxide（DB11）
9beta,11beta-Epoxy-17alpha
981-34-0
Intermediates & Fine Chemicals
Metabolites & Impurities
