ChemicalBook >> CAS DataBase List >>1-(tert-Butoxycarbonyl)-3-pyrrolidinol

1-(tert-Butoxycarbonyl)-3-pyrrolidinol

1-(tert-Butoxycarbonyl)-3-pyrrolidinol structure

CAS No.: 103057-44-9

Chemical Name:: 1-(tert-Butoxycarbonyl)-3-pyrrolidinol

Synonyms: Tert-butyl 3-hydroxypyrrolidine-1-carboxylate;3-HYDROXY-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-BOC-3-HYDROXYPYRROLIDINE;1-Pyrrolidinecarboxylic acid, 3-hydroxy-, 1,1-diMethylethyl ester;Zinc00403504;CAS:103057-44-9;N-boc-3-Pyrrolidinol;1-Boc-3-HydroxypyrroL;1-Boc-3-hydropyrrolidine;1-Boc-3-pyrrolidinol 95%

CBNumber:: CB7232378

Molecular Formula:: C9H17NO3

Molecular Weight:: 187.24

MDL Number:: MFCD04038535

MOL File:: 103057-44-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 03:04:27

Product description	Number	Pack Size	Price
1-Boc-3-pyrrolidinol 95%	706620	5g	$126
1-Boc-3-pyrrolidinol 95%	706620	1g	$29
1-(tert-Butoxycarbonyl)-3-pyrrolidinol >98.0%(GC)	B3603	5g	$48
1-(tert-Butoxycarbonyl)-3-pyrrolidinol >98.0%(GC)	B3603	25g	$154
1-Boc-3-pyrrolidinol	262873	2g	$305
More product size

Request For Quotation

1-(tert-Butoxycarbonyl)-3-pyrrolidinol Properties

Melting point	62.1-62.2°C
Boiling point	273.3±33.0 °C(Predicted)
Density	1.142±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	soluble in Methanol
form	powder to crystal
pka	14.74±0.20(Predicted)
color	White to Almost white
optical activity	Consistent with structure
InChI	InChI=1S/C9H17NO3/c1-9(2,3)13-8(12)10-5-4-7(11)6-10/h7,11H,4-6H2,1-3H3
InChIKey	APCBTRDHCDOPNY-UHFFFAOYSA-N
SMILES	N1(C(OC(C)(C)C)=O)CCC(O)C1
CAS DataBase Reference	103057-44-9(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H301-H315-H319-H335

Precautionary statements

P301+P310+P330-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Hazard Codes

Xi,T

Risk Statements

36/37/38-25

Safety Statements

26-36/37/39-37-45-36/37

RIDADR

2811

WGK Germany

HazardClass

IRRITANT

PackingGroup

Ⅲ

HS Code

29339900

Storage Class

6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications

Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

1-(tert-Butoxycarbonyl)-3-pyrrolidinol price More Price(80)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	706620	1-Boc-3-pyrrolidinol 95%	103057-44-9	5g	$126	2026-04-30	Buy
Sigma-Aldrich	706620	1-Boc-3-pyrrolidinol 95%	103057-44-9	1g	$29	2023-06-20	Buy
TCI Chemical	B3603	1-(tert-Butoxycarbonyl)-3-pyrrolidinol >98.0%(GC)	103057-44-9	5g	$48	2026-04-30	Buy
TCI Chemical	B3603	1-(tert-Butoxycarbonyl)-3-pyrrolidinol >98.0%(GC)	103057-44-9	25g	$154	2026-04-30	Buy
Usbiological	262873	1-Boc-3-pyrrolidinol	103057-44-9	2g	$305	2026-06-03	Buy

Product number	Packaging	Price	Buy
706620	5g	$126	Buy
706620	1g	$29	Buy
B3603	5g	$48	Buy
B3603	25g	$154	Buy
262873	2g	$305	Buy

1-(tert-Butoxycarbonyl)-3-pyrrolidinol Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

1-Boc-3-pyrrolidinol is an intermediate for the preparation of pyrrolidinone-containing pseudopeptides, inhibitors of HIV-1 protease.

Synthesis

24424-99-5

40499-83-0

83220-73-9

The general procedure for the synthesis of 1-tert-butoxycarbonyl-3-hydroxy-pyrrolidine from di-tert-butyl dicarbonate and 3-hydroxy-pyrrolidine was carried out as follows: firstly, (R)-3-pyrrolidinol (539 mg, 6.19 mmol) was converted to compound 16b to afford the colorless oily material (1.3 g, 100% yield). The spectral data of this compound were consistent with the expected structure and in accordance with literature reports (see Kucznierz, R. et al. J. Med. Chem. 1998, 41, 4983-4994). Subsequently, compound 16b was converted by reaction to compound 16c, again as a colorless oil. Next, compound 16c was converted by a two-step reaction to compound 16e, still a colorless oily substance. Finally, compound 16e was reacted to produce the target compound 16, which was rendered as a yellow oily substance.

References

[1] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 10, p. 969 - 973
[2] Patent: WO2015/9731, 2015, A2. Location in patent: Paragraph 00106
[3] Journal of Medicinal Chemistry, 1998, vol. 41, # 25, p. 4983 - 4994
[4] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 17, p. 5812 - 5832
[5] Patent: WO2010/84767, 2010, A1. Location in patent: Page/Page column 86

1-(tert-Butoxycarbonyl)-3-pyrrolidinol Preparation Products And Raw materials

Raw materials

Di-tert-butyl dicarbonate N-Boc-3-pyrrolidinone 3-Pyrrolidinol (R)-(-)-3-Pyrrolidinol hydrochloride Triethylamine

1,4-Dioxane

1of2

Preparation Products

1-Boc-3-Methylaminopyrrolidine tert-Butyl 3-aminopyrrolidine-1-carboxylate Methyl 1-Boc-3-pyrrolidinecarboxylate 1-N-Boc-3-Cyanopyrrolidine 3-(Pyridin-3-yloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester

1-(tert-Butoxycarbonyl)-3-pyrrolidinol Suppliers

Global( 278)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Changzhou Ditong Chemical Co.,Ltd	+86-0519-88298848	info@edengenechem.com	China	2165	58
BTC Nantong Pharmaceuticals Technology Co.,Ltd	+86-0513-81283365	Info@btcpharm.com	China	251	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Jinan Carbotang Biotech Co.,Ltd.	58
Accela ChemBio Inc.	58
Changzhou Ditong Chemical Co.,Ltd	58
BTC Nantong Pharmaceuticals Technology Co.,Ltd	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58

View Lastest Price from 1-(tert-Butoxycarbonyl)-3-pyrrolidinol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-06-05	1-(tert-Butoxycarbonyl)-3-pyrrolidinol 103057-44-9		1KG	98%min	30tons/month	WUHAN FORTUNA CHEMICAL CO., LTD
2026-03-20	1-(tert-Butoxycarbonyl)-3-pyrrolidinol 103057-44-9	$10.00	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2024-02-26	1-(tert-Butoxycarbonyl)-3-pyrrolidinol 103057-44-9		1kg	98%		BTC Nantong Pharmaceuticals Technology Co.,Ltd

1-(tert-Butoxycarbonyl)-3-pyrrolidinol
103057-44-9
$0.00
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

1-(tert-Butoxycarbonyl)-3-pyrrolidinol
103057-44-9
$10.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

1-(tert-Butoxycarbonyl)-3-pyrrolidinol
103057-44-9
98%
BTC Nantong Pharmaceuticals Technology Co.,Ltd

1-(tert-Butoxycarbonyl)-3-pyrrolidinol Spectrum

1-(tert-Butoxycarbonyl)-3-pyrrolidinol(103057-44-9)¹HNMR

103057-44-9(1-(tert-Butoxycarbonyl)-3-pyrrolidinol)Related Search:

BUTYL OLEATE N-Methyl-2-pyrrolidone Pyrrolidine N-Vinyl-2-pyrrolidone tert-Butyl peroxyacetate

tert-Butyl acetate Cyhalofop-butyl CHLOROPHOSPHONAZO III Tris(trimethylsilyl)phosphate Buprofezin

3-Pyrrolidinol Butyl acetate Butyl acrylate tert-Butanol Polyvinylpyrrolidone

1-Azetidinecarboxylic acid, 3-methylene-, 1,1-dimethylethyl ester METHYL-2-PYRROLIDONE N-Boc-trans-4-tosyloxy-L-proline methyl ester

1of4

1-BOC-3-HYDROXYPYRROLIDINE 1-N-BOC-3-HYDROXY-PYRROLIDINE N-BOC-3-HYDROXYPYRROLIDINE N-(TERT-BUTOXYCARBONYL)-3-HYDROXYPYRROLIDINE (S) 1-BOC-3-hydroxylpyrrolidine 3-Hydroxypyrrolidine, N-BOC protected Tert-butyl 3-hydroxypyrrolidinecarboxylate N-boc-3-Pyrrolidinol (R)-3-Hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester (R)-N-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine DL-1-BOC-3-HYDROXY-PYRROLIDINE -BOC-3-HYDROXYPYRROLIDINE (r)-1-boc-3-hydroxypyrrolidineester 1-Boc-3-hydropyrrolidine Zinc00403504 1-Boc-3-hydroxypyrrolidin... 1-Boc-3-hydroxypyrrolidine ,95% 1-tert-Butoxycarbonyl-3-hydroxypyrrolid tert-Butyl 3-hydroxypyrrolidine-1-carbox 1-(tert-Butoxycarbonyl)-3-pyrrolidinol t-Butyl 3-hydroxypyrrolidine-1-carboxylate 1-Pyrrolidinecarboxylic acid, 3-hydroxy-, 1,1-diMethylethyl ester (R)-tert-butyl 3-hydro×ypyrrolidine-1-carbo×ylate 1-(tert-Butyloxycarbonyl)-3-hydroxypyrrolidine 1,1-DiMethylethyl 3-Hydroxypyrrolidine-1-carboxylate 1-Boc-3-pyrrolidinol 1-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine 1-Boc-3-hydroxypyrrolidine tert-Butyl 3-hydroxypyrrolidine-1-carboxylate, 1-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine (R)-1-Boc-3-hydroxypyrrolidine SynonyMs (R)-N-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine 1-Boc-3-pyrrolidinol, >=97% 1-Boc-3-pyrrolidinol 95% 3-hydroxy-1-pyrrolidinecarboxylic acid tert-butyl ester 1-(tert-Butoxycarbonyl)-3-pyrrolidinol > 1-Boc-3-HydroxypyrroL tert-Butyl-(3S)-3-hydroxypyrrolidin-1-carboxylate CAS:103057-44-9 1-Boc-3-pyrrolidinol(tert-butyl 3-hydroxypyrrolidine-1-carboxylate 3-HYDROXY-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Tert-butyl 3-hydroxypyrrolidine-1-carboxylate 103057-44-9 C9H17NO3 C9H17O3N Aliphatics Alcohols and Derivatives Heterocycles Pyrrolidines Pyrrole&Pyrrolidine&Pyrroline pharmacetical