SB 200646 HYDROCHLORIDE
- CAS No.
- 143797-63-1
- Chemical Name:
- SB 200646 HYDROCHLORIDE
- Synonyms
- SB 200646;SB200646HCl;SB 200646 HYDROCHLORIDE;SB-200646, 10 mM in DMSO;N-(1-methyl-5-indolyl)-N'-(3-pyridyl)urea;N-(1-Methyl-1H-indol-5-yl)-N'-3-pyridinylurea;1-(1-Methyl-1H-indol-5-yl)-3-pyridin-3-yl-urea;Urea, N-(1-methyl-1H-indol-5-yl)-N'-3-pyridinyl-;N-(1-METHYL-1H-INDOL-5-YL)-N'-3-PYRIDINYLUREA HYDROCHLORIDE;N-(1-METHYL-1H-5-INDOLYL)-N'-(3-PYRIDINYL)UREA HYDROCHLORIDE
- CBNumber:
- CB7234079
- Molecular Formula:
- C15H14N4O
- Molecular Weight:
- 266.3
- MDL Number:
- MFCD00913519
- MOL File:
- 143797-63-1.mol
| Product description | Number | Pack Size | Price |
| SB200646hydrochloride ≥98%(HPLC) | 1371 | 10 | $116 |
| SB200646hydrochloride ≥98%(HPLC) | 1371 | 50 | $488 |
| SB 200646 HYDROCHLORIDE 95.00% | API0009920 | 5MG | $496.01 |
| N-(1-Methyl-1H-indol-5-yl)-N'-3-pyridinylurea 95% | 147865 | 5mg | $740 |
| N-(1-Methyl-1H-indol-5-yl)-N'-3-pyridinylurea 95% | 147865 | 10mg | $1110 |
| storage temp. | 2-8°C |
|---|---|
| solubility | DMSO: ~26 mg/mL, soluble |
| form | solid |
| color | pale yellow |
| Water Solubility | Water: 1 mg/mL (NaN mM) |
| FDA UNII | RT8F72CL8L |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
SB 200646 HYDROCHLORIDE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 1371 | SB200646hydrochloride ≥98%(HPLC) | 143797-63-1 | 10 | $116 | 2021-12-16 | Buy |
| Tocris | 1371 | SB200646hydrochloride ≥98%(HPLC) | 143797-63-1 | 50 | $488 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0009920 | SB 200646 HYDROCHLORIDE 95.00% | 143797-63-1 | 5MG | $496.01 | 2021-12-16 | Buy |
| Matrix Scientific | 147865 | N-(1-Methyl-1H-indol-5-yl)-N'-3-pyridinylurea 95% | 143797-63-1 | 5mg | $740 | 2021-12-16 | Buy |
| Matrix Scientific | 147865 | N-(1-Methyl-1H-indol-5-yl)-N'-3-pyridinylurea 95% | 143797-63-1 | 10mg | $1110 | 2021-12-16 | Buy |
SB 200646 HYDROCHLORIDE Chemical Properties,Uses,Production
Uses
SB 200646 Hydrochloride is a 5-HT2C antagonist.
Definition
ChEBI: SB 200646 is a member of indoles.
Biological Activity
5-HT 2C/2B receptor antagonist, selective over 5-HT 1A . Affinities are 7.4 (pA 2 ), 6.9 (pK i ) and 5.2 (pK i ) for 5-HT 2B , 2C and 2A respectively. Orally active in vivo .
in vivo
SB-200646A (20 mg/kg; intravenous injection; daily; for 21 days; male albino Sprague-Dawley rats) treatment significantly decreases the number of spontaneously active ventral tegmental area (VTA) dopaminergic neurons[1].
The i.v. administration of 4-16 mg/kg of SB-200646A significantly increases the firing rate and % events as bursts in spontaneously active VTA dopaminergic neurons and significantly increases the % events as burst in substantia nigra pars compacta (SNC) dopaminergic neurons[1].
| Animal Model: | Male albino Sprague-Dawley rats (200-225 g at the beginning of treatment and 300-350 g at the time of the experiment)[1] |
| Dosage: | 20 mg/kg |
| Administration: | Intravenous injection; daily; for 21 days |
| Result: | Significantly decreased the number of spontaneously active ventral tegmental area (VTA) dopaminergic neurons. |
IC 50
5-HT2B Receptor: 7.5 (pKi); 5-HT2C Receptor: 6.9 (pKi); 5-HT2A Receptor: 5.2 (pKi)
SB 200646 HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
SB 200646 HYDROCHLORIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32470 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39042 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15838 | 69 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71615 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9430 | 55 |
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