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9-Fluorenylmethyl chloroformate

9-Fluorenylmethyl chloroformate Structure
9-Fluorenylmethyl chloroformate structure
CAS No.
28920-43-6
Chemical Name:
9-Fluorenylmethyl chloroformate
Synonyms
FMOC-CL;FoMc-Cl;(9H-fluoren-9-yl)Methyl carbonochloridate;fmoc-ci;9-Fluorenylmethyl;FMOC-C;FMOC-CHLORIDE;1-(9-fluorenyl)methylchloroformate;9-FLUORENYLMETHOXYCARBONYL CHLORIDE;Fluorenylmethyloxycarbonyl chloride
CBNumber:
CB7234569
Molecular Formula:
C15H11ClO2
Molecular Weight:
258.7
MDL Number:
MFCD00001138
MOL File:
28920-43-6.mol
MSDS File:
SDS
Last updated:2026-01-13 11:24:38
Product description Number Pack Size Price
(9-Fluorenylmethyl) chloroformate Novabiochem? 8.52259 25g $56
(9-Fluorenylmethyl) chloroformate for synthesis 8.18203 500mg $35.1
(9-Fluorenylmethyl) chloroformate Novabiochem? 8.52259 100g $158
(9-Fluorenylmethyl) chloroformate for synthesis 8.18203 5G $119
(9-Fluorenylmethyl) chloroformate for synthesis 8.18203 25g $307
More product size
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9-Fluorenylmethyl chloroformate Properties

Melting point 62-64 °C(lit.)
Boiling point 365.79°C (rough estimate)
Density 1.1780 (rough estimate)
refractive index 1.5330 (estimate)
storage temp. 2-8°C
solubility dioxane: 0.1 g/mL, clear, colorless
form Crystalline Powder
color White to very pale yellow
Sensitive Moisture Sensitive
BRN 2279177
Stability Hygroscopic, Moisture Sensitive
InChI InChI=1S/C15H11ClO2/c16-15(17)18-9-14-12-7-3-1-5-10(12)11-6-2-4-8-13(11)14/h1-8,14H,9H2
InChIKey IRXSLJNXXZKURP-UHFFFAOYSA-N
SMILES C(Cl)(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O
LogP 3.45
CAS DataBase Reference 28920-43-6(CAS DataBase Reference)
FDA UNII 9PLB0BTT90
UNSPSC Code 12352108
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS05
Signal word  Danger
Hazard statements  H314
Precautionary statements  P260-P280-P301+P330+P331-P303+P361+P353-P304+P340+P310-P305+P351+P338
PPE Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Hazard Codes  C,T
Risk Statements  34-20/21/22
Safety Statements  26-36/37/39-45-27
RIDADR  UN 3261 8/PG 2
WGK Germany  3
RTECS  LQ6250000
F  10-21
TSCA  No
HazardClass  6.1
PackingGroup  II
HS Code  29159020
Storage Class 8A - Combustible corrosive hazardous materials
Hazard Classifications Eye Dam. 1
Skin Corr. 1B
Limited Quantities 1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)
NFPA 704
1
3 1

9-Fluorenylmethyl chloroformate price More Price(64)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.52259 (9-Fluorenylmethyl) chloroformate Novabiochem? 28920-43-6 25g $56 2025-07-31 Buy
Sigma-Aldrich 8.18203 (9-Fluorenylmethyl) chloroformate for synthesis 28920-43-6 500mg $35.1 2025-07-31 Buy
Sigma-Aldrich 8.52259 (9-Fluorenylmethyl) chloroformate Novabiochem? 28920-43-6 100g $158 2025-07-31 Buy
Sigma-Aldrich 8.18203 (9-Fluorenylmethyl) chloroformate for synthesis 28920-43-6 5G $119 2025-07-31 Buy
Sigma-Aldrich 8.18203 (9-Fluorenylmethyl) chloroformate for synthesis 28920-43-6 25g $307 2025-07-31 Buy
Product number Packaging Price Buy
8.52259 25g $56 Buy
8.18203 500mg $35.1 Buy
8.52259 100g $158 Buy
8.18203 5G $119 Buy
8.18203 25g $307 Buy

9-Fluorenylmethyl chloroformate Chemical Properties,Uses,Production

Description

9-Fluorenylmethyl chloroformate (Fmoc-C1) is a significant biochemical reagent introduced by Carpino. It has been widely utilized as a reagent for the introduction of the 9-fluorenylmethoxycarbonyl (Fmoc moiety) in both peptide and nucleotide synthesis, as well as serving as a coupling agent in peptide synthesis[1]. Furthermore, Fmoc-C1 can function as a versatile fluorescent labeling reagent for primary and secondary amines[2].

Chemical Properties

9-Fluorenyl chloroformate appears as white crystals with a melting point of 62–64 °C. It is soluble in organic solvents such as CH₂Cl₂, THF, and dioxane. It reacts with alcohols, ammonia or amines, and water.

Uses

9-Fluorenylmethyl chloroformate can be used as N-protecting reagent for oligonucleotide and peptide syntheses. It can act as reagent for the introduction of Fmoc-amino-protecting group, which is stable towards acids but is readily cleaved under mildly basic non-hydrolytic conditions.

Uses

9-Fluorenylmethyl chloroformate is an N-Protecting agent for peptides research and was used for the pre-column derivatization of the biogenic amines (BAs) cadaverine (Cad), histamine (Him), octopami ne (Ocp), phenylethylamine (Pea), putrescine (Put), spermidine (Spd), spermine (Spm), tyramine (Tym).

General Description

Fmoc chloride is a derivatizing agent.

Flammability and Explosibility

Not classified

Safety Profile

A poison. Mutation data reported. A corrosive. When heated to decomposition it emits toxic vapors of Cl-.

Purification Methods

If the IR contains no OH bands (at ~3000 cm-1) due to the hydrolysis product 9-fluorenylmethanol, then purify it by recrystallisation from dry Et2O. IR (CHCl3) has a band at 1770 cm-1 (C=O), and the NMR (CDCl3) has  at 4-4.6 (m 2H, CHCH2) and 7.1-7.8 (m, 8 aromatic H) ppm. The azide (FMOC-N3) has m 89-90o (from -1hexane) and IR (CHCl3) at 2135 (N3) and 1730 (C=O) cm , and the carbazate (FMOC-NHNH2) has m 171o(dec) (from nitromethane), IR (KBr) 3310, 3202 (NH) and 1686 (CONH) cm-1. [Caprino & Han J Org Chem 37, 3404 1972 , J Am Chem Soc 92 5748 1970, Koole et al. J Org Chem 59 1657 1989, Fürst et al. J Chromatogr 499 537 1990.]

References

[1] S. TANTRY; V. V B; G Vasanthakumar. Synthesis of peptides employing 9-fluorenylmethyl chloroformate as a coupling agent[J]. Letters in peptide science?: LIPS, 2006, 10 1: 51-55. DOI:10.1007/BF02443642.
[2] H. A. MOYE  A. B. A Versatile Fluorogenic Labelling Reagent for Primary and Secondary Amines: 9-Fluorenylmethyl Chloroformate[J]. Analytical Letters, 1979, 12 1: 25-35. DOI:10.1080/00032717908082516.

9-Fluorenylmethyl chloroformate Preparation Products And Raw materials

Raw materials

9-Fluorenemethanol

Preparation Products

2-Ethylpiperazine Fmoc-8-amino-3,6-dioxaoctanoic acid 3-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-ISONICOTINIC ACID Fmoc-D-phenylalanine FMOC-2-AMINONICOTINIC ACID
Fmoc-Ile-OH Carbamic acid, N-(3-chloro-3-oxopropyl)-, 9H-fluoren-9-ylmethyl ester Tyrosine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]- Fmoc-L-phenylglycine Fmoc-L-4-Iodophenylalanine
Fmoc-4-nitro-L-phenylalanine FMOC-NLE-OH FMOC-L-Arginine Fmoc-Cys(tBu)-OH N-Boc-N'-Fmoc-L-Lysine
Fmoc-L-hydroxyproline FMOC-(2S,3R)-2-AMINO-3-HYDROXY-4-METHYLPENTANOIC ACID FMOC-2-(2-AMINOETHOXY)ETHANOL

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9-Fluorenylmethyl chloroformate Suppliers

Global( 672)Suppliers
Supplier Tel Email Country ProdList Advantage
Suzhou Highfine Biotech Co.,Ltd. 		+86-0512-68071238 +86-13771819922 june@highfine.com China 489 58
Allfluoro pharmaceutical co. ltd. 		+86-400-0216110 +86-15958047586 sales@allfluoro.com China 11385 58
Zepeptide Biotechnology (Shijiazhuang) Co., Ltd
+86-86-13383293380 +8613230482270 1919301810@qq.com China 141 58
Xinxiang Juyuan Biological Technology Co., Ltd.
+8615637360870 sales@xxkfqchem.com China 19 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20128 58
Hebei Zhuanglai Chemical Trading Co Ltd 		+86-16264648883 niki@zlchemi.com China 7245 58
Springchem New Material Technology Co.,Limited 		+86-021-62885108 +8613917661608 info@spring-chem.com China 2068 57
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13636 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21599 55
Supplier Advantage
Suzhou Highfine Biotech Co.,Ltd. 		58
Allfluoro pharmaceutical co. ltd. 		58
Zepeptide Biotechnology (Shijiazhuang) Co., Ltd
58
Xinxiang Juyuan Biological Technology Co., Ltd.
58
Henan Fengda Chemical Co., Ltd 		58
Hebei Zhuanglai Chemical Trading Co Ltd 		58
Springchem New Material Technology Co.,Limited 		57
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55

Related articles

Related Qustion

Ask a question
Q:What are the structural characteristics of 9-Fluorenylmethyl chloroformate?Anonymous - Aug 19，2025
A:The 9-Fluorenylmethyl chloroformate(FMOC-CL) molecule consists of a fluorenyl group and a chloroformate group. The fluorenyl group is an aromatic ring structure with unique optical properties, while the chloroformate group is a reactive acyl chloride group that reacts with amines, alcohols, and other compounds.
Q:What is 9-Fluorenylmethyl chloroformate?Anonymous - Aug 19，2025
A:9-Fluorenylmethyl chloroformate, also known as FMOC-CL, is a highly versatile reagent with varied applications in organic synthesis. It is most frequently used to introduce the base-labile Fmoc-protecting group to amine functionalities, particularly during the production of Fmoc-protected amino acids.

View Lastest Price from 9-Fluorenylmethyl chloroformate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
FMOC-CL pictures 2026-01-30 FMOC-CL
28920-43-6
 US $750.00 / kg 1kg 99 50tons Xinxiang Juyuan Biological Technology Co., Ltd.
9-Fluorenylmethyl chloroformate pictures 2025-12-16 9-Fluorenylmethyl chloroformate
28920-43-6
 US $0.00-0.00 / KG 1KG 98 10000KGS Shaanxi Dideu New Materials Co. Ltd
9-Fluorenylmethyl chloroformate pictures 2025-09-25 9-Fluorenylmethyl chloroformate
28920-43-6
 US $8.00-1.00 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
  • FMOC-CL pictures
  • FMOC-CL
    28920-43-6
  • US $750.00 / kg
  • 99
  • Xinxiang Juyuan Biological Technology Co., Ltd.

9-Fluorenylmethyl chloroformate Spectrum

9-Fluorenylmethyl chloroformate(28920-43-6)MS9-Fluorenylmethyl chloroformate(28920-43-6)1HNMR9-Fluorenylmethyl chloroformate(28920-43-6)IR19-Fluorenylmethyl chloroformate(28920-43-6)Raman

28920-43-6(9-Fluorenylmethyl chloroformate)Related Search:

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1-(9-fluorenyl)methylchloroformate CHLOROFORMIC ACID 9-FLUORENYLMETHYL ESTER EMOCCI FMOC-CL FMOC-CHLORIDE fmoc-ci 9-FLUORENYLMETHYL CHLOROFORMATE (FMOC CL) Fmoc-Cl(9-FluorenylmethoxycarbonylChloride) Fmoc-Clsee22072 9-Fluorenylmethyl (9h-fluoren-9-ylmethoxy)carbonyl chloride FMOC-CL CHLOROFORMIC ACID 9-FLUORENYLMETHYL ESTER 9-Fluorenylmethoxycarbonyl chloride (Fmoc-Cl) FMOC-CL, 9-FLLUORENYLMETHYL CHLOROFOMATE Fmco-chloride(9-Fluorenyl methyl chloroformate) Chloroformic acid 9H-fluoren-9-ylmethyl ester 9-Fluorenylmethyl Chloroformate [N-Protecting Agent for Peptides Research] 9-Fluorenylmethylchloroformate,98% 9-FLUOROMETHANOL ( FMOC ) 9-FLUOROMETHANOL ( FMOC-ONSU ) FMOC-CL (9-FLUORENYLMETHYL CHLOROFORMATE) 9-Fluorenylmethylchloroformate (Fmoc-chloride) 9-Fluorenylmethoxycarbonyl chloride, 9-Fluorenylmethyl chloroformate, Fmoc-Cl 9-Fluorenylmethyl chlorocarbonate AminoTag FMoc chloride 97% FMOC chloride [FMOC-CL] 9-FluorenylMethyl ChloroforMate, 97+% Fmoc chloride, >=98% 9 - fluorene chlorine Methyl forMate Fmoc-Chloride≥ 98% (HPLC) (9-Fluorenylmethyl) chloroformate Novabiochem (9-Fluorenylmethyl) chloroformate for synthesis 9-Fluorenylmethyl chloroformat (9H-Fluoren-9-yl)MethOxy]Carbonyl Cl Chloroformic acid 9-fluorenylmethyl ester(Fmoc-CL) 9-Fluorenylmethyl chloroformate, Chloroformic acid 9-fluorenylmethyl este, Fmoc-Cl chloro-formicacifluoren-9-ylmethylester Formicacid,chloro-,fluoren-9-ylmethylester N-9-FLUORENYLMETHYL CHLOROFORMATE RARECHEM FM OC 0001 9h-fluoren-9-ylmethyl chloroformate 9-FLUORENYLMETHYLOXYCARBONYL CHLORIDE 9-FLUOROENYLMETHYL CHLOROFORMATE 9-FLUORENEMETHYL CHLOROFORMATE 9-FLUORENMETHYL CHLOROFORMATE 9-FLUORENYLMETHYL CHLOROFORMATE 9-FLUORENYLMETHOXYCARBONYL CHLORIDE 9-(Chloroformyloxymethyl)-9H-fluorene Chloridocarbonic acid (9H-fluoren-9-yl)methyl ester Chlorocarbonic acid (9H-fluoren-9-ylmethyl) ester Chloroformic acid (9H-fluoren-9-yl)methyl CARBONOCHLORIDIC ACID, 9H-FLUOREN-9-YLMETHYL ESTER 9-Fluoroe Fmoc chloride,9-Fluorenylmethoxycarbonyl chloride, 9-Fluorenylmethyl chloroformate, Fmoc-Cl Chloroformic acid 9- (9H-Fluoren-9-yl)methyl carbonochloridoate 9-FluorenylMethyl chloroforMate, 98% 1GR