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3,4,5-Trimethoxycinnamic acid

3,4,5-Trimethoxycinnamic acid structure

CAS No.: 90-50-6

Chemical Name:: 3,4,5-Trimethoxycinnamic acid

Synonyms: AKOS BBS-00000775;RARECHEM BK HC T328;o-methylsinapicacid;OTAVA-BB BB7119152925;TRIMETHOXYCINNAMICACID;3,4,5-Trimethoxycinnamic;3,4,5-Trimethoxyzimtsure;5-TriMethoxycinnaMic acid;3,4,5-Trimethoxycinmic acid;3,4,5-trimethoxy-cinnamicaci

CBNumber:: CB7236422

Molecular Formula:: C12H14O5

Molecular Weight:: 238.24

MDL Number:: MFCD00004388

MOL File:: 90-50-6.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:54

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3,4,5-Trimethoxycinnamic acid Properties

Melting point	125-127 °C (lit.)
Boiling point	300.83°C (rough estimate)
Density	1.1416 (rough estimate)
vapor pressure	0-0Pa at 20-25℃
refractive index	1.4571 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka	4.48±0.10(Predicted)
form	Solid:crystalline
color	White
BRN	1537834
InChI	InChI=1S/C12H14O5/c1-15-9-6-8(4-5-11(13)14)7-10(16-2)12(9)17-3/h4-7H,1-3H3,(H,13,14)
InChIKey	YTFVRYKNXDADBI-UHFFFAOYSA-N
SMILES	C(O)(=O)C=CC1=CC(OC)=C(OC)C(OC)=C1
LogP	0.3-1.1 at 35℃ and pH2-7
CAS DataBase Reference	90-50-6(CAS DataBase Reference)
FDA UNII	C9096D920O
EPA Substance Registry System	2-Propenoic acid, 3-(3,4,5-trimethoxyphenyl)- (90-50-6)
UNSPSC Code	85151701
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Safety Statements

24/25

WGK Germany

RTECS

GE0722000

TSCA

Yes

HazardClass

IRRITANT

HS Code

29189900

NFPA 704

	0
1		0

3,4,5-Trimethoxycinnamic acid price More Price(23)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	T70408	3,4,5-Trimethoxycinnamic acid 97%	90-50-6	25g	$58.9	2022-05-15	Buy
TRC	T896038	3,4,5-Trimethoxycinnamic acid	90-50-6	10g	$60	2021-12-16	Buy
Frontier Specialty Chemicals	JK275960	3,4,5-Trimethoxycinnamic acid 99%	90-50-6	100g	$241	2021-12-16	Buy
Biorbyt Ltd	orb594658	3,4,5-Trimethoxycinnamic acid	90-50-6	1000mg	$187	2021-12-16	Buy
Frontier Specialty Chemicals	JK275960	3,4,5-Trimethoxycinnamic acid 99%	90-50-6	25g	$73	2021-12-16	Buy

Product number	Packaging	Price	Buy
T70408	25g	$58.9	Buy
T896038	10g	$60	Buy
JK275960	100g	$241	Buy
orb594658	1000mg	$187	Buy
JK275960	25g	$73	Buy

3,4,5-Trimethoxycinnamic acid Chemical Properties,Uses,Production

Chemical Properties

white to cream fine crystalline powder

Uses

3-(3,4,5-Trimethoxyphenyl)acrylic acid demonstrates antioxidant activity as it was detected to inhibit lipid peroxidation in rat brain homogenates.

Definition

ChEBI: A methoxycinnamic acid with three methoxy substituents at the 3-, 4- and 5-positions.

Synthesis

141-82-2

86-81-7

20329-98-0

Example IV Synthesis of 3,4,5-trimethoxycinnamic acid (by microwave radiation method): in a 100 mL Erlenmeyer flask, a mixture of 3,4,5-trimethoxybenzaldehyde (5.0 g, 0.025 mol) and malonic acid (5.30 g, 0.050 mol) was added, followed by piperidine (4-8 mL) and acetic acid (25-35 mL). The flask was fitted with a loose funnel at the top and the mixture was shaken well and placed in a microwave oven and microwaved in batches for 4-8 min. Upon completion of the reaction, the cooled mixture was poured into ice-cold water and acidified with 5% HCl solution. The precipitated yellow solid was collected by filtration and recrystallized by aqueous ethanol to give 3,4,5-trimethoxycinnamic acid in 88% yield; the melting point was 127 °C (literature value 126-128 °C). The spectral data of the product were consistent with those reported in the literature: 1H NMR (CDCl3) δ 7.73 (1H, d, J = 16.0 Hz, -CH=CH-COOH), 6.78 (2H, s, H-2 and H-6), 6.38 (1H, d, J = 16.0 Hz, CH=CH-COOH), 3.91 (9H, s, 3-OCH3, 4- OCH3, 5-OCH3); 13C NMR: δ 172.6 (COOH), 153.8 (C-3 and C-5), 147.4 (C-4), 140.8 (CH=CH-COOH), 129.8 (C-1), 116.8 (CH=CH-COOH), 105.8 (C-2 and C-6), 61.4 (4- OCH3), 56.5 (3-OCH3 and 5-OCH3).

target

5-HT Receptor | ERK | GABA Receptor | HIF-2

References

[1] MedChemComm, 2017, vol. 8, # 4, p. 755 - 766
[2] European Journal of Medicinal Chemistry, 2015, vol. 95, p. 473 - 482
[3] Medicinal Chemistry Research, 2016, vol. 25, # 6, p. 1074 - 1086
[4] Chemistry Letters, 2003, vol. 32, # 12, p. 1186 - 1187
[5] Patent: US2004/118673, 2004, A1. Location in patent: Page 7

3,4,5-Trimethoxycinnamic acid Preparation Products And Raw materials

Raw materials

3,4,5-TRIMETHOXYCINNAMIC ACID ETHYL ESTER Malonic acid 3,4,5-Trimethoxybenzaldehyde

Preparation Products

3,4,5-Trimethoxycinnamic acid Suppliers

Global( 382)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8617732866630	abby@chuanghaibio.com	China	8773	58
Hebei Mujin Biotechnology Co.,Ltd	+8613288715578	sales@hbmojin.com	China	12303	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5251	58
airuikechemical co., ltd.	+86-18353166132	sales02@airuikechemical.com	China	983	58
Shandong Deshang Chemical Co., Ltd.	+86-0531-8875-2665 +8613153039501	info@deshangchem.com	China	661	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29855	58
Chengdu GLP biotechnology Co Ltd	028-87075086 13350802083	scglp@glp-china.com	CHINA	1824	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2953	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Mujin Biotechnology Co.,Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
airuikechemical co., ltd.	58
Shandong Deshang Chemical Co., Ltd.	58
career henan chemical co	58
Chengdu GLP biotechnology Co Ltd	58
Hubei Jusheng Technology Co.,Ltd.	58
Jinan Finer Chemical Co., Ltd	58
Hubei xin bonus chemical co. LTD	58

View Lastest Price from 3,4,5-Trimethoxycinnamic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-08-08	3,4,5-Trimethoxycinnamic acid 90-50-6	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mujin Biotechnology Co.,Ltd
2025-06-24	3,4,5-Trimethoxycinnamic acid 90-50-6	US $10.00 / KG	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-05-26	3,4,5-Trimethoxycinnamic Acid 90-50-6	US $5.00-2.00 / KG	1KG	99%	10000kg	Hebei Chuanghai Biotechnology Co,.LTD

3,4,5-Trimethoxycinnamic acid
90-50-6
US $0.00 / KG
99%
Hebei Mujin Biotechnology Co.,Ltd

3,4,5-Trimethoxycinnamic acid
90-50-6
US $10.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

3,4,5-Trimethoxycinnamic Acid
90-50-6
US $5.00-2.00 / KG
99%
Hebei Chuanghai Biotechnology Co,.LTD

3,4,5-Trimethoxycinnamic acid Spectrum

3,4,5-Trimethoxycinnamic acid(90-50-6)MS 3,4,5-Trimethoxycinnamic acid(90-50-6)¹HNMR 3,4,5-Trimethoxycinnamic acid(90-50-6)¹³CNMR 3,4,5-Trimethoxycinnamic acid(90-50-6)IR1 3,4,5-Trimethoxycinnamic acid(90-50-6)IR2 3,4,5-Trimethoxycinnamic acid(90-50-6)Raman

90-50-6(3,4,5-Trimethoxycinnamic acid)Related Search:

trans-Cinnamic acid Octyl 4-methoxycinnamate 3-(Trifluoromethyl)cinnamic acid Methyl cinnamate Ethyl cinnamate

alpha-Methylcinnamic acid Cinnamyl cinnamate 3,4-Dimethoxycinnamonitrile 4-Methoxycinnamic acid 3,4,5-TRIMETHOXYCINNAMIC ACID ETHYL ESTER

3,4,5-TRIMETHOXYCINNAMIC ACID SODIUM SALT trans-2,4,5-Trimethoxycinnamic acid TRANS-2,3,4-TRIMETHOXYCINNAMIC ACID,2,3,4-TRIMETHOXYCINNAMIC ACID,Trans-2,3,4-trimethoxycinnamic acid 99% 3,4,5-Trimethoxycinnamic acid, methyl reserpate 2,4,6-TRIMETHOXYCINNAMIC ACID

2,4,6-TRIMETHOXYCINNAMIC ACID ETHYL ESTER 3,4,5-Trimethoxycinnamic acid ISOPENTYL TRIMETHOXYCINNAMATE TRISILOXANE

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RARECHEM BK HC T328 OTAVA-BB BB7119152925 3-(3,4,5-trimethoxyphenyl)-2-propenoicaci 3-(3,4,5-trimethoxyphenyl)-2-propenoicacid 3,4,5-trimethoxy-cinnamicaci 3,4,5-TriMethoxycinnaMic acid, predoMinantly trans, 99% 5GR 3, 4, 5 - triMethoxy CinnaMate 3,4,5-TrimethoxyClnnamic aCld 3,4,5-Trimethoxycinmic acid 2-Propenoicacid, 3-(3,4,5-trimethoxyphenyl)- (E)-3-(3,4,5-trimethoxyphenyl)-2-propenoate 3,4,5-trimethoxyphenylacrylicacid o-methylsinapicacid (E)-3-(3,4,5-TRIMETHOXY-PHENYL)-ACRYLIC ACID 3,4,5-TRIMETHOXYCINNAMIC ACID 3-(3,4,5-TRIMETHOXYPHENYL)ACRYLIC ACID AKOS BBS-00000775 3,4,5-Trimethoxycinnamic 3,4,5-TRIMETHOXYCINNAMIC ACID, 97%, PRED OMINANTLY TRANS 3,4,5-TrimethoxycinnamicAcid,~99% 3,4,5-Trimethoxycinnamic acid, predominantly trans, 99% (E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoic acid TRIMETHOXYCINNAMICACID 3,4,5-Trimethoxyzimtsure 5-TriMethoxycinnaMic acid 3-(3,4,5-Trimethoxyphenyl)propenoic acid 3,4,5-Trimethoxybenzeneacrylic acid 3,4,5-Trimethoxycinnamic acid, 99%, predominantly trans (2E)-3-(3,4,5-trimethoxyphenyl)acrylic acid ,4,5-Trimethoxycinnamic acid 3,4,5-Trimethoxycinnamic acid,3,4,5-Trimethoxyzimtsure,RARECHEM BK HC T328,3,4,5-Trimethoxycinnamic,TRIMETHOXYCINNAMICACID,o- 3,4,5-TrimethoxyClnnamic acid 3,4,5-Trimethoxycinnamic acid, 10 mM in DMSO 90-50-6 95-50-6 Carboxylic Acids Carbonyl Compounds C11 to C12 Building Blocks Organic Building Blocks Aromatic Cinnamic Acids, Esters and Derivatives Cinnamic acid Organic acids C11 to C12 Carbonyl Compounds Carboxylic Acids Inhibitors 90-50-6 11