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Ethyl imidazo[1,2-a]pyrimidine-3-carboxylate

Ethyl imidazo[1,2-a]pyrimidine-3-carboxylate structure

CAS No.: 64951-07-1

Chemical Name:: Ethyl imidazo[1,2-a]pyrimidine-3-carboxylate

Synonyms: Nsc296230;ETHYL IMIDAZO[1,2-A]PYRIMIDINE-3-CARBOXYLATE;ethyl imidazo[1,2-a]pyrimidine-7-carboxylate;ETHYL IMIDAZO[1,2-A]PYRIMIDINE-3-CARBOXYLATE ISO 9001：2015 REACH

CBNumber:: CB72460700

Molecular Formula:: C9H9N3O2

Molecular Weight:: 191.19

MDL Number:: MFCD10698087

MOL File:: 64951-07-1.mol

MSDS File:: SDS

Last updated:2026-05-28 02:41:48

Product description	Number	Pack Size	Price
Ethyl imidazo[1,2-a]pyrimidine-3-carboxylate	PCA95107	5g	$472
Ethyl imidazo[1,2-a]pyrimidine-3-carboxylate >95%	OR110094	100mg	$36
Ethyl imidazo[1,2-a]pyrimidine-3-carboxylate >95%	OR110094	250mg	$37
Ethyl imidazo[1,2-a]pyrimidine-3-carboxylate >95%	OR110094	1g	$55
Ethyl imidazo[1,2-a]pyrimidine-3-carboxylate >95%	OR110094	5g	$266

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Ethyl imidazo[1,2-a]pyrimidine-3-carboxylate Properties

Density	1.33±0.1 g/cm3(Predicted)
storage temp.	2-8°C
pka	2.70±0.30(Predicted)
Appearance	White to off-white Solid
InChI	InChI=1S/C9H9N3O2/c1-2-14-8(13)7-6-11-9-10-4-3-5-12(7)9/h3-6H,2H2,1H3
InChIKey	FGZMTIBNGQUEDE-UHFFFAOYSA-N
SMILES	C12=NC=C(C(OCC)=O)N1C=CC=N2

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H317
Precautionary statements	P280
HS Code	2933599590

Ethyl imidazo[1,2-a]pyrimidine-3-carboxylate price More Price(63)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Biosynth	PCA95107	Ethyl imidazo[1,2-a]pyrimidine-3-carboxylate	64951-07-1	5g	$472	2026-06-04	Buy
Apolloscientific	OR110094	Ethyl imidazo[1,2-a]pyrimidine-3-carboxylate >95%	64951-07-1	100mg	$36	2026-06-04	Buy
Apolloscientific	OR110094	Ethyl imidazo[1,2-a]pyrimidine-3-carboxylate >95%	64951-07-1	250mg	$37	2026-06-04	Buy
Apolloscientific	OR110094	Ethyl imidazo[1,2-a]pyrimidine-3-carboxylate >95%	64951-07-1	1g	$55	2026-06-04	Buy
Apolloscientific	OR110094	Ethyl imidazo[1,2-a]pyrimidine-3-carboxylate >95%	64951-07-1	5g	$266	2026-06-04	Buy

Product number	Packaging	Price	Buy
PCA95107	5g	$472	Buy
OR110094	100mg	$36	Buy
OR110094	250mg	$37	Buy
OR110094	1g	$55	Buy
OR110094	5g	$266	Buy

Ethyl imidazo[1,2-a]pyrimidine-3-carboxylate Chemical Properties,Uses,Production

Synthesis

109-12-6

70-23-5

Ethyl imidazo[1,2-a]pyrimidine-3-carboxylate

64951-07-1

IMIDAZO[1,2-A]PYRIMIDINE-2-CARBOXYLIC ACID ETHYL ESTER

64951-06-0

2-Aminopyrimidine (5 g, 52.6 mmol) and ethyl 3-bromopyruvate (90% purity, 7.35 mL, 52.6 mmol) were dissolved in ethanol (80 mL) and the reaction mixture was heated to 75°C for 16 hours. After completion of the reaction, the reaction mixture was concentrated under reduced pressure and diluted with an aqueous solution of dichloromethane (CH2Cl2) and saturated sodium bicarbonate (NaHCO3). The organic layer was washed twice with saturated aqueous NaHCO3 and the aqueous layer was extracted three times with CH2Cl2. The organic layers were combined, dried with anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure. The brown oil obtained was suspended in cold CH2Cl2, filtered, and the filter cake was washed with cold CH2Cl2 to give ethyl imidazo[1,2-a]pyrimidine-2-carboxylate (3 g, 30% yield) as a light yellow oil. The mother liquor contained a mixture of ethyl imidazo[1,2-a]pyrimidine-2-carboxylate and ethyl imidazo[1,2-a]pyrimidine-3-carboxylate (6 g, 60% yield) as a viscous black oil. This black oil was first purified by silica gel column chromatography and then recrystallized from ethyl acetate (EtOAc) to give pure ethyl imidazo[1,2-a]pyrimidine-3-carboxylate (2 g, 20% yield). For the 2-isomer: 1H NMR (500 MHz, CDCl3) δ 8.69 (dd, J = 2.2,6.6 Hz, 1H), 8.67 (dd, J = 2.2,4.4 Hz, 1H), 8.22 (s, 1H), 7.01 (dd, J = 3.9,6.6 Hz, 1H), 4.46 (q, J = 7.2 Hz, 2H). 1.43 (t, J = 7.2Hz, 3H).13C NMR (500MHz, CDCl3) δ162.8,152.2,147.8,137.7,134.4,115.3,110.0,61.2,14.2.HPLC-MS Phenomenex LUNA C-18 4.6 x 50 mm, 0 to 100% B, 4 min, 1 min hold time, A = 90% water, 10% methanol, 0.1% TFA, B = 10% water, 90% methanol, 0.1% TFA, RT = 0.99 min, 95% homogeneity index.LCMS: Analysis. Calculated.Measured result for C9H9N3O2 191.07 Measured value: 192.13 (M + H)+. For the 3-isomer: HPLC Phenomenex LUNA C-18 4.6 x 50 mm, 0 to 100% B, 4 min, 1 min retention time, A = 90% water, 10% methanol, 0.1% TFA, B = 10% water, 90% methanol, 0.1% TFA, RT = 1.39 min, 100% homogeneity index. lcms: calc. 191.07 measured value for C9H9N3O2: 192.19 (M + H)+.

References

[1] Patent: WO2006/71752, 2006, A1. Location in patent: Page/Page column 83
[2] European Journal of Medicinal Chemistry, 1994, vol. 29, # 4, p. 279 - 286
[3] European Journal of Medicinal Chemistry, 1991, vol. 26, # 1, p. 13 - 18
[4] Journal of Medicinal Chemistry, 2010, vol. 53, # 15, p. 5620 - 5628
[5] Patent: WO2018/11628, 2018, A1. Location in patent: Paragraph 00266

Ethyl imidazo[1,2-a]pyrimidine-3-carboxylate Preparation Products And Raw materials

Raw materials

2-Aminopyrimidine Ethyl bromopyruvate

Preparation Products

Ethyl imidazo[1,2-a]pyrimidine-3-carboxylate Suppliers

Global( 81)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Accendatech Co., Ltd.	+8613132578992	yunhao.liu@accendatech.com	China	251	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
Wuhan ChemNorm Biotech Co.,Ltd.	+86-27-8439 4403 18971486879	sales@chemnorm.com	CHINA	2935	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	9996	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52705	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418684 +8618949823763	sales@tnjchem.com	China	25356	58
Golden Pharma Co., Limited	+undefined18958062155	sales@zjgoldpharm.com	China	5899	58
PT CHEM GROUP LIMITED	+86-85511178;	peter68@ptchemgroup.com	China	35425	58
GIHI CHEMICALS CO.,LIMITED	+86-571-86217390; +8618058761490	info@gihichemicals.com	China	49969	58

Supplier	Advantage
Accendatech Co., Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
Wuhan ChemNorm Biotech Co.,Ltd.	58
Shaanxi Dideu Medichem Co. Ltd	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Golden Pharma Co., Limited	58
PT CHEM GROUP LIMITED	58
GIHI CHEMICALS CO.,LIMITED	58

View Lastest Price from Ethyl imidazo[1,2-a]pyrimidine-3-carboxylate manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-06-25	ETHYL IMIDAZO[1,2-A]PYRIMIDINE-3-CARBOXYLATE 64951-07-1	$1.10	1g	99.0% min	100 tons min	Shaanxi Dideu Medichem Co. Ltd

ETHYL IMIDAZO[1,2-A]PYRIMIDINE-3-CARBOXYLATE
64951-07-1
$1.10
99.0% min
Shaanxi Dideu Medichem Co. Ltd

Ethyl imidazo[1,2-a]pyrimidine-3-carboxylate Spectrum

Ethyl imidazo[1,2-a]pyrimidine-3-carboxylate(64951-07-1)¹HNMR

64951-07-1(Ethyl imidazo[1,2-a]pyrimidine-3-carboxylate)Related Search:

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Nsc296230 ethyl imidazo[1,2-a]pyrimidine-7-carboxylate ETHYL IMIDAZO[1,2-A]PYRIMIDINE-3-CARBOXYLATE ETHYL IMIDAZO[1,2-A]PYRIMIDINE-3-CARBOXYLATE ISO 9001：2015 REACH 64951-07-1