PIPERLONGUMINE
- CAS No.
- 20069-09-4
- Chemical Name:
- PIPERLONGUMINE
- Synonyms
- PIPLARTINE;ong;PPLGM;umine;PiperL;ongumine;acryloyl);Piplartin;PIPERLONGUMIN;Piperlorgumia
- CBNumber:
- CB7246450
- Molecular Formula:
- C17H19NO5
- Molecular Weight:
- 317.34
- MDL Number:
- MFCD00075706
- MOL File:
- 20069-09-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Piperlongumine ≥97% (HPLC) | SML0221 | 5mg | $143 |
| Piperlongumine | 528124 | 25mg | $94 |
| Piperlongumine >97.0%(HPLC) | P2361 | 25mg | $88 |
| Piperlongumine >97.0%(HPLC) | P2361 | 100mg | $313 |
| Piperlongumine ≥98% | 11006 | 25mg | $49 |
| More product size | |||
| Melting point | 124°C |
|---|---|
| Boiling point | 475.6±45.0 °C(Predicted) |
| Density | 1.223±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥5mg/mL at warmed to 60°C |
| pka | -1.88±0.20(Predicted) |
| form | powder |
| color | white to beige |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| Cosmetics Ingredients Functions |
SKIN CONDITIONING - MISCELLANEOUS ANTIOXIDANT BLEACHING |
| InChI | InChI=1S/C17H19NO5/c1-21-13-10-12(11-14(22-2)17(13)23-3)7-8-16(20)18-9-5-4-6-15(18)19/h4,6-8,10-11H,5,9H2,1-3H3/b8-7+ |
| InChIKey | VABYUUZNAVQNPG-BQYQJAHWSA-N |
| SMILES | C1(=O)N(C(=O)/C=C/C2=CC(OC)=C(OC)C(OC)=C2)CCC=C1 |
| LogP | 2.340 (est) |
| FDA UNII | SGD66V4SVJ |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H320-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UU7785850 | |||||||||
| HS Code | 2932209090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
|
PIPERLONGUMINE price More Price(122)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0221 | Piperlongumine ≥97% (HPLC) | 20069-09-4 | 5mg | $143 | 2026-04-30 | Buy |
| Sigma-Aldrich | 528124 | Piperlongumine | 20069-09-4 | 25mg | $94 | 2026-04-30 | Buy |
| TCI Chemical | P2361 | Piperlongumine >97.0%(HPLC) | 20069-09-4 | 25mg | $88 | 2026-04-30 | Buy |
| TCI Chemical | P2361 | Piperlongumine >97.0%(HPLC) | 20069-09-4 | 100mg | $313 | 2021-12-16 | Buy |
| Cayman Chemical | 11006 | Piperlongumine ≥98% | 20069-09-4 | 25mg | $49 | 2026-04-30 | Buy |
PIPERLONGUMINE Chemical Properties,Uses,Production
Description
A piperidinone alkaloid present in Piper longum, the structure has been shown to be N-(3:4:5-trimethoxycinnamoyl)-Lls-piperidin-2-one. In the plant, the base occurs mainly in the roots.
Uses
Piperlongumine has been used to study the regulation of protein regulator of cytokinesis 1 (PRC1) expression. It has also been used to investigate its anti-tumor effects on human melanoma cells in vitro.
Uses
Piperlongumine (PL), a new alkaloid abundantly present in Piper longum fruits strongly inhibited platelet cell aggregation. It may have anti-cancer properties. It selectively targets and kills cancer cells but leaving normal cells unharmed.
Uses
anti-asthma, antibronchitis
Definition
ChEBI: Piplartine is a member of cinnamamides and a dicarboximide.
General Description
Piperlongumine is an alkaloid, which is extracted from Piper longum Linn. It exhibits anti-atherosclerotic, anxiolytic, antidiabetic, antidepressant, antibacterial, anti-platelet, aggregation, anxiolytic and anti-inflammatory properties. Piperlongumine prevents the production of tumor necrosis factor-α and interleukin-6. It blocks the activation of nuclear factor-κB (NF-κB) against proinflammatory responses. Piperlongumine inhibits plaque formation and inhibits vascular smooth muscle cell migration. It is used to treat cough, respiratory infections and stomach-ache.
Biochem/physiol Actions
Piperlongumine selectively kills cancer cells regardless of p53 status without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1). It increases the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells with little effect on either rapidly or slowly dividing primary normal cells. Piperlongumine showed significant antitumour effects in a variety of mouse tumour models and inhibited growth of spontaneously formed malignant breast tumours and their associated metastases.
target
P450 (e.g. CYP17) | Antifection
References
Chatterjee, Dutta., Tetrahedron, 23, 1769 (1967)
PIPERLONGUMINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hydebio Labs Co.,Limited | +86-18100690299 +86-18100690299 | mrkt@hydebiolabs.com | China | 108 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21588 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| Chengdu Greenpure Biopharma CO.,Ltd | 18283602253; +8618283602253 | jancyzheng@gcgreenpure.com | China | 954 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
View Lastest Price from PIPERLONGUMINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-16 | Piperlongumine
20069-09-4
|
$22.00 | 1kg | 99% | 1000kg/month | GIHI CHEMICALS CO.,LIMITED | |
 |
2026-03-20 | PIPERLONGUMINE
20069-09-4
|
$10.00 | 1kg | 99% | 100 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-05-23 | PIPERLONGUMINE
20069-09-4
|
$50.00 | 1kg | 99 | 5000 | Hebei Zhuanglai Chemical Trading Co Ltd |
-
- Piperlongumine
20069-09-4
- $22.00
- 99%
- GIHI CHEMICALS CO.,LIMITED
-
- PIPERLONGUMINE
20069-09-4
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- PIPERLONGUMINE
20069-09-4
- $50.00
- 99
- Hebei Zhuanglai Chemical Trading Co Ltd
