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COPTISINE

COPTISINE Structure
COPTISINE structure
CAS No.
3486-66-6
Chemical Name:
COPTISINE
Synonyms
Coptisin;COPTISINE;COPTISINE(P);Coptisine Sulfate;2-Benzenedioic acid;COPTISINE USP/EP/BP;Coptisine, 10 mM in DMSO;Coptisine, 98%, from Coptis chinensis Franch.;6,7-Dihydrobis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizinium;Bis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizinium,6,7-dihydro-
CBNumber:
CB7246829
Molecular Formula:
C19H14NO4+
Molecular Weight:
320.32
MDL Number:
MFCD03792689
MOL File:
3486-66-6.mol
Last updated:2025-09-05 20:24:49
Request For Quotation

COPTISINE Properties

Melting point 212-217 °C
storage temp. Store at 2-8°C
solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form Powder
FDA UNII 0GCL71VN14

SAFETY

Risk and Safety Statements

Hazardous Substances Data 3486-66-6(Hazardous Substances Data)

COPTISINE price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 300099 Coptisine 3486-66-6 20mg $575 2021-12-16 Buy
Biosynth Carbosynth FC73787 Coptisine 3486-66-6 50mg $375 2021-12-16 Buy
Biorbyt Ltd orb594640 Coptisine sulfate 3486-66-6 20mg $499.8 2021-12-16 Buy
Medical Isotopes, Inc. 73969 Coptisine 98% 3486-66-6 20mg $500 2021-12-16 Buy
American Custom Chemicals Corporation PXT0002161 COPTISINE 95.00% 3486-66-6 5MG $503.55 2021-12-16 Buy
Product number Packaging Price Buy
300099 20mg $575 Buy
FC73787 50mg $375 Buy
orb594640 20mg $499.8 Buy
73969 20mg $500 Buy
PXT0002161 5MG $503.55 Buy

COPTISINE Chemical Properties,Uses,Production

Uses

Coptisine is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitive IDO inhibitor with a Ki value of 5.8 μM and an IC50 value of 6.3 μM.

Definition

ChEBI: A natural product found in Coptis japonica.

Hazard

A poison.

Safety Profile

A poison by ingestion. When heated to decomposition it emits toxic vapors of NOx.

in vivo

Coptisine shows increased toxicity in mice in a concentration dependent manner, with LD50 value of 880.18 mg/kg. Coptisine (154 mg/kg/day, 90 days) shows no toxicity on SD rats. Coptisine (23.35, 46.7, 70.05 mg/kg, p.o.) dose-dependently decreases the levels of TC, TG, and LDL-c and increases HDL-c content in serum of hamsters to different degree, slows down weight gain induced by the HFHC diet, and raises the level of cholesterol and TBA in feces dose-dependently in hamsters. Coptisine (70.05 mg/kg, p.o.) suppresses HMGCR protein expression level and induces the protein expression of SREBP-2, LDLR, and CYP7A1 involved in cholesterol metabolism[2].

IC 50

IDO: 6.3 μM (IC50); IDO: 5.8 μM (Ki)

References

[1] Yu D, et al. The IDO inhibitor coptisine ameliorates cognitive impairment in a mouse model of Alzheimer's disease. J Alzheimers Dis. 2015;43(1):291-302. DOI:10.3233/JAD-140414
[2] He K, et al. The safety and anti-hypercholesterolemic effect of coptisine in Syrian golden hamsters. Lipids. 2015 Feb;50(2):185-94. DOI:10.1007/s11745-014-3983-7
[3] Rao PC, et al. Coptisine-induced cell cycle arrest at G2/M phase and reactive oxygen species-dependent mitochondria-mediated apoptosis in non-small-cell lung cancer A549 cells. Tumour Biol. 2017 Mar;39(3):1010428317694565. DOI:10.1177/1010428317694565

COPTISINE synthesis

130-86-9
3486-66-6
Synthesis of COPTISINE from Protopine

COPTISINE Preparation Products And Raw materials

Raw materials

4H-Bis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizine, 6,7-dihydro- Protopine Berberine 5-BROMO-1 3-BENZODIOXOLE-4-CARBOXALDEHY& 8-Oxocoptisine
5,6,7,8-TETRAHYDRO-[1,3]DIOXOLO[4,5-G]ISOQUINOLINE

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Preparation Products

COPTISINE Suppliers

Global( 179)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Dideu Medichem Co. Ltd 		+86-029-81138252 +86-173 9270 1263 1057@dideu.com China 4000 58
Shanghai Zheyan Biotech Co., Ltd. 		18017610038 zheyansh@163.com CHINA 3619 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29855 58
Chengdu Biopurify Phytochemicals Ltd. 		+86-28-82633860; +8618080483897 sales@biopurify.com China 3751 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28172 58
Wuhan ChemNorm Biotech Co.,Ltd. 		+86-27-8439 4403 18971486879 sales@chemnorm.com CHINA 2935 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32430 58
ANHUI WITOP BIOTECH CO., LTD 		+8615255079626 eric@witopchemical.com China 23541 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 20800 58
Finetech Industry Limited 		+86-27-8746-5837 +8619945049750 info@finetechnology-ind.com China 9629 58
Supplier Advantage
Shaanxi Dideu Medichem Co. Ltd 		58
Shanghai Zheyan Biotech Co., Ltd. 		58
career henan chemical co 		58
Chengdu Biopurify Phytochemicals Ltd. 		58
Hubei Jusheng Technology Co.,Ltd. 		58
Wuhan ChemNorm Biotech Co.,Ltd. 		58
TargetMol Chemicals Inc. 		58
ANHUI WITOP BIOTECH CO., LTD 		58
Dideu Industries Group Limited 		58
Finetech Industry Limited 		58

View Lastest Price from COPTISINE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Coptisine pictures 2025-09-05 Coptisine
3486-66-6
 US $38.00-139.00 / mg 99.91% 10g TargetMol Chemicals Inc.
Coptisine pictures 2024-07-11 Coptisine
3486-66-6
 US $1.00 / KG 1KG 98% 20T Shaanxi Dideu Medichem Co. Ltd
COPTISINE pictures 2021-11-02 COPTISINE
3486-66-6
 US $630.00 / G 1G 98% 100kgs Baoji Guokang Healthchem co.,ltd
  • Coptisine pictures
  • Coptisine
    3486-66-6
  • US $38.00-139.00 / mg
  • 99.91%
  • TargetMol Chemicals Inc.
  • Coptisine pictures
  • Coptisine
    3486-66-6
  • US $1.00 / KG
  • 98%
  • Shaanxi Dideu Medichem Co. Ltd
  • COPTISINE pictures
  • COPTISINE
    3486-66-6
  • US $630.00 / G
  • 98%
  • Baoji Guokang Healthchem co.,ltd

3486-66-6(COPTISINE)Related Search:

Cevadine veratramine daurisoline 2-[2-(Methylamino)benzoyl]-3,4-dihydro-β-carboline-1(2H)-one VERATRIDINE
L-Hyoscyamine Worenine menisdaurin Xanthiazone Tetrahydroepiberberine, Sinactine
5,6-Dihydro-2,3-(methylenedioxy)-9,10-dimethoxy-13-methyldibenzo[a,g]quinolizinium Daurinoline Xanthiside epiberberine (-)-STYLOPINE
COPTISINE COPTISINE CHLORIDE,COPTISINE CHLORIDE(P) COPTISINE CHLORIDE(RG)

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COPTISINE Coptisin 5,6-Dihydro-2,3:9,10-bis(methylenedioxy)dibenzo[a,g]quinolizinium 6,7-Dihydrobis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizinium Coptisine Sulfate Coptisine, 98%, from Coptis chinensis Franch. COPTISINE(P) Bis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizinium,6,7-dihydro- COPTISINE USP/EP/BP 2-Benzenedioic acid 6,7-Dihydro-[1,3]dioxolo[4',5':7,8]isoquinolino[3,2-a][1,3]dioxolo[4,5-g]isoquinolin-5-ium Coptisine, 10 mM in DMSO 3486-66-6 C19H14NO4 chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract Alkaloids