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1-tert-Butyl 2-methyl (2R)-4-oxopyrrolidine-1,2-dicarboxylate

1-tert-Butyl 2-methyl (2R)-4-oxopyrrolidine-1,2-dicarboxylate structure

CAS No.: 256487-77-1

Chemical Name:: 1-tert-Butyl 2-methyl (2R)-4-oxopyrrolidine-1,2-dicarboxylate

Synonyms: 1-(tert-Butyl) 2-methyl (R)-4-oxopyrrolidine-1,2-dicarboxylate;Boc-4-OXO-D-Pro-Ome;N-Boc-4-oxo-L-Pro.Ome;N-Boc-4-oxo-L-proline m;Methyl N-Boc-4-keto-D-prolinate;Boc-4-oxo-D-proline Methyl ester;(2R)-N-Boc-4-oxo-D-proline methyl ester;N-Boc-4- oxygen -D- proline methyl ester;(R)-N-Boc-2-Methoxycarbonyl-4-pyrrolidone;N-Boc-4-oxo-L-proline methyl ester USP/EP/BP

CBNumber:: CB72469884

Molecular Formula:: C11H17NO5

Molecular Weight:: 243.26

MDL Number:: MFCD09954936

MOL File:: 256487-77-1.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:48

Product description	Number	Pack Size	Price
N-Boc-4-oxo-D-ProlineMethylEster	B661535	100mg	$50
(R)-1-tert-Butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate 97+% ee	AS72006	1g	$65
(R)-1-tert-Butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate 95%	057296	1g	$70
(R)-1-tert-Butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate 95%	057296	250mg	$35
(R)-1-tert-Butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate	4H58-1-9P	1g	$150
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1-tert-Butyl 2-methyl (2R)-4-oxopyrrolidine-1,2-dicarboxylate Properties

Boiling point	333.1±42.0 °C(Predicted)
Density	1.209
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	-3.86±0.40(Predicted)
Appearance	Off-white to yellow Solid-Liquid Mixture
InChI	InChI=1S/C11H17NO5/c1-11(2,3)17-10(15)12-6-7(13)5-8(12)9(14)16-4/h8H,5-6H2,1-4H3/t8-/m1/s1
InChIKey	UPBHYYJZVWZCOZ-MRVPVSSYSA-N
SMILES	N1(C(OC(C)(C)C)=O)CC(=O)C[C@@H]1C(OC)=O

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H319-H315-H335
Precautionary statements	P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
HazardClass	IRRITANT
HS Code	2933998090

1-tert-Butyl 2-methyl (2R)-4-oxopyrrolidine-1,2-dicarboxylate price More Price(24)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	B661535	N-Boc-4-oxo-D-ProlineMethylEster	256487-77-1	100mg	$50	2021-12-16	Buy
Activate Scientific	AS72006	(R)-1-tert-Butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate 97+% ee	256487-77-1	1g	$65	2021-12-16	Buy
Matrix Scientific	057296	(R)-1-tert-Butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate 95%	256487-77-1	1g	$70	2021-12-16	Buy
Matrix Scientific	057296	(R)-1-tert-Butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate 95%	256487-77-1	250mg	$35	2021-12-16	Buy
SynQuest Laboratories	4H58-1-9P	(R)-1-tert-Butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate	256487-77-1	1g	$150	2021-12-16	Buy

Product number	Packaging	Price	Buy
B661535	100mg	$50	Buy
AS72006	1g	$65	Buy
057296	1g	$70	Buy
057296	250mg	$35	Buy
4H58-1-9P	1g	$150	Buy

1-tert-Butyl 2-methyl (2R)-4-oxopyrrolidine-1,2-dicarboxylate Chemical Properties,Uses,Production

Uses

N-Boc-4-oxo-D-Proline methyl ester is a useful chemical reagent.

Synthesis

(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate

114676-69-6

1-tert-Butyl 2-methyl (2R)-4-oxopyrrolidine-1,2-dicarboxylate

256487-77-1

General procedure for the synthesis of (R)-1-tert-butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylates from methyl (2R,4R)-1-Boc-4-hydroxypyrrolidine-2-carboxylate: Step 1: Oxidation reaction Pyridinium dichromate (9.97 g, 26.5 mmol) was dissolved in dichloromethane (60 mL) at room temperature and slowly added to a dichloromethane solution of methyl (2R,4R)-1-Boc-4-hydroxypyrrolidine-2-carboxylate (5.00 g, 20.39 mmol). The reaction mixture was stirred at room temperature overnight. After completion of the reaction, diatomaceous earth (5 g) was added and stirring was continued for 40 min, followed by filtration. The filter cake was washed with dichloromethane (50 mL x 3). The filtrates were combined, concentrated to dryness under reduced pressure, added toluene (40 mL) and concentrated again to give about 6.5 g of brown slurry-like crude product. Purification step The crude product was purified by fast silica gel column chromatography (120 g silica gel column, eluent EtOAc/hexane, gradient 0 to 100%, flow rate 85 mL/min) to afford 4.18 g (84% yield) of (R)-1-tert-butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate as a white solid. Product characterization LCMS (condition A): m/z 144 (M-Boc)-ve. 1H NMR (400 MHz, CDCl3) δ ppm: 4.44-4.89 (1H, m), 3.84-3.96 (2H, m), 3.77 (3H, s), 2.81-3.10 (1H, m), 2.59 (1H, dd, J = 18.93, 1.76 Hz), 1.52 (9H, s).

References

[1] Patent: WO2012/125887, 2012, A1. Location in patent: Page/Page column 74-75
[2] Patent: WO2012/125886, 2012, A1. Location in patent: Page/Page column 85
[3] Patent: WO2015/94902, 2015, A1. Location in patent: Page/Page column 20; 21
[4] Journal of Medicinal Chemistry, 1999, vol. 42, # 26, p. 5426 - 5436
[5] Patent: TW2017/8221, 2017, A. Location in patent: Page/Page column 41; 42

1-tert-Butyl 2-methyl (2R)-4-oxopyrrolidine-1,2-dicarboxylate Preparation Products And Raw materials

Raw materials

N-Boc-Trans-4-Hydroxy-D-proline methyl ester (2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate Pyridinium chlorochromate Dichloromethane

Preparation Products

Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate

1-tert-Butyl 2-methyl (2R)-4-oxopyrrolidine-1,2-dicarboxylate Suppliers

Global( 137)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Sichuan HongRi Pharma-Tech Co.,Ltd	+8617390183901	cynthia@enlaibio.com	China	1100	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29799	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10035	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
Win-Win chemical CO., Limited	+86-0086-577-64498589 +86-15355981851	sales@win-winchemical.com	China	14360	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	20287	58

Supplier	Advantage
Sichuan HongRi Pharma-Tech Co.,Ltd	58
Jinan Carbotang Biotech Co.,Ltd.	58
Accela ChemBio Inc.	58
Hubei xin bonus chemical co. LTD	58
career henan chemical co	58
Fuxin Pharmaceutical	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
SIMAGCHEM CORP	58
Win-Win chemical CO., Limited	58
Dideu Industries Group Limited	58

View Lastest Price from 1-tert-Butyl 2-methyl (2R)-4-oxopyrrolidine-1,2-dicarboxylate manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-10-24	N-Boc-4-oxo-L-proline methyl ester 256487-77-1	US $0.00-0.00 / kg	1kg	98%	1T	Sichuan HongRi Pharma-Tech Co.,Ltd
	2020-01-01	N-Boc-4-oxo-L-proline methyl ester 256487-77-1	US $1.00 / KG	1KG	99%	200kg	Career Henan Chemical Co

N-Boc-4-oxo-L-proline methyl ester
256487-77-1
US $0.00-0.00 / kg
98%
Sichuan HongRi Pharma-Tech Co.,Ltd

N-Boc-4-oxo-L-proline methyl ester
256487-77-1
US $1.00 / KG
99%
Career Henan Chemical Co

1-tert-Butyl 2-methyl (2R)-4-oxopyrrolidine-1,2-dicarboxylate Spectrum

N-Boc-4-oxo-L-proline methyl ester(256487-77-1)¹HNMR

256487-77-1(1-tert-Butyl 2-methyl (2R)-4-oxopyrrolidine-1,2-dicarboxylate)Related Search:

1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate

1-tert-butyl 2-Methyl (2R)-4-oxopyrrolidine-1,2-dicarboxylate Methyl N-Boc-4-keto-D-prolinate (R)-N-Boc-2-Methoxycarbonyl-4-pyrrolidone (2R)-4-oxo-1,2-Pyrrolidinedicarboxylic acid 1-(tert-butyl) 2-methyl ester Boc-4-oxo-D-proline Methyl ester Methyl (2R)-1-Boc-4-oxo-pyrrolidinecarboxylate methyl (R)-1-tert-butoxycarbonyl-4-oxopyrrolidine-2-carboxylate (2R)-4-oxo-1,2-Pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) 2-methyl ester 1-O-tert-butyl 2-O-methyl (2R)-4-oxopyrrolidine-1,2-dicarboxylate (R)-4-Oxo-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 1,2-Pyrrolidinedicarboxylic acid, 4-oxo-, 1-(1,1-dimethylethyl) 2-methyl ester, (2R)- N-Boc-4-oxo-L-proline methyl ester USP/EP/BP Boc-4-OXO-D-Pro-Ome (2R)-N-Boc-4-oxo-D-proline methyl ester 1-(tert-Butyl) 2-methyl (R)-4-oxopyrrolidine-1,2-dicarboxylate N-Boc-4-oxo-L-proline m N-Boc-4-oxo-L-Pro.Ome N-Boc-4- oxygen -D- proline methyl ester 256487-77-1