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AZD1152

AZD1152 Structure
AZD1152 structure
CAS No.
722543-31-9
Chemical Name:
AZD1152
Synonyms
AZD1152;CS-1053;Barasertib (AZD1152);Barasertib, 10 mM in DMSO;BARASERTIB; AZD-1152; AZD 1152;5-[[7-[3-[Ethyl[2-(phosphonooxy)ethyl]amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-1H-pyrazole-3-acetamide;1H-Pyrazole-3-acetamide, 5-[[7-[3-[ethyl[2-(phosphonooxy)ethyl]amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-;2-(Ethyl(3-((4-((3-(2-((3-fluorophenyl)amino)-2-oxoethyl)-1H-pyrazol-5-yl)amino)quinazolin-7-yl)oxy)propyl)amino)ethyl dihydrogen phosphate;2-[[3-({4-[(5-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-3-yl)amino]quinazolin-7-yl}oxy)propyl](ethyl)amino]ethyl dihydrogen phosphate
CBNumber:
CB72476033
Molecular Formula:
C26H31FN7O6P
Molecular Weight:
587.54
MDL Number:
MFCD15146330
MOL File:
722543-31-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-08-05 09:01:00
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AZD1152 Properties

Density 1.463
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
solubility insoluble in H2O; insoluble in EtOH; ≥5.88 mg/mL in DMSO
form solid
pka 1.75±0.10(Predicted)
color Off-white to light yellow
FDA UNII 16XC2U7W8N

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

AZD1152 price More Price(49)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 13647 AZD 1152 ≥95% 722543-31-9 1mg $65 2021-12-16 Buy
Cayman Chemical 13647 AZD 1152 ≥95% 722543-31-9 5mg $293 2021-12-16 Buy
Biosynth FE18067 AZD 1152 722543-31-9 2mg $150 2026-06-04 Buy
Biosynth FE18067 AZD 1152 722543-31-9 1mg $150 2026-06-04 Buy
Biosynth FE18067 AZD 1152 722543-31-9 5mg $190.5 2026-06-04 Buy
Product number Packaging Price Buy
13647 1mg $65 Buy
13647 5mg $293 Buy
FE18067 2mg $150 Buy
FE18067 1mg $150 Buy
FE18067 5mg $190.5 Buy

AZD1152 Chemical Properties, Uses, Production

Uses

Barasertib. is a selective inhibitor of Aurora B kinase, which inhibits human tumor xenograft growth by inducing apoptosis.

Definition

ChEBI: AZT-1152 is a dihydrogen phosphate prodrug of a pyrazoloquinazoline aurora kinase inhibitor AZD1152-hydroxyquinazoline pyrazol anilide(HQPA) and is converted rapidly to the active AZD1152-HQPA in plasma. It has a role as a prodrug, an antineoplastic agent and an Aurora kinase inhibitor. It is a member of quinazolines, a monoalkyl phosphate, an anilide, a member of monofluorobenzenes, a member of pyrazoles, a secondary amino compound, a secondary carboxamide and a tertiary amino compound. It is functionally related to an AZD-1152.

in vivo

Barasertib (AZD1152, 25 mg/kg) markedly suppresses the growth and weights of AZD1152-treated tumors[1].
Barasertib (AZD1152, 5 mg/kg) enhances the ability of vincristine or daunorubicin to inhibit the proliferation of human MOLM13 leukemic xenografts[1].
Barasertib (AZD1152, (10-150 mg/kg/d) potently inhibited the growth of human colon, lung, and hematologic tumor xenografts (mean tumor growth inhibition range, 55% to z100%; P < 0.05) in immunodeficient mice[2].

Animal Model:Female immune-deficient BALB/c nude mice (MOLM13 cells injected)[1].
Dosage:5 or 25 mg/kg.
Administration:Intraperitoneal injection 4 times a week or every another day.
Result:Inhibited the growth of human MOLM13 cells growing as xenografts using an immunodeficient murine model.

IC 50

Aurora B: 0.37 nM (IC50)

AZD1152 Preparation Products And Raw materials

Raw materials

Preparation Products

AZD1152 Suppliers

Global Suppliers ( 123)
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Shanghai Topbiochem Technology Co., Ltd 021-58170097 info@topbiochem.com China 9509 58
NCE Biomedical Co.,Ltd. 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 China 1490 55
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7545 61
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4853 58
AdooQ BioScience, LLC +1 (866) 930-6790 info@adooq.com United States 2774 58
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
AdooQ Bioscience CHINA 025-58849295 info@adooq.cn China 2981 60
Shanghai XingMo Biotechnology Co., Ltd. +86 13524779951; 13524779951 2075692521@qq.com China 294 55
LETOPHARM LIMITED +86-21-5821 5861 sales@letopharm.com China 2374 58
Supplier Advantage
Capot Chemical Co., Ltd 66
Shanghai Topbiochem Technology Co., Ltd 58
NCE Biomedical Co.,Ltd. 55
Haoyuan Chemexpress Co., Ltd. 61
MedChemexpress LLC 58
AdooQ BioScience, LLC 58
Bide Pharmatech Ltd. 60
AdooQ Bioscience CHINA 60
Shanghai XingMo Biotechnology Co., Ltd. 55
LETOPHARM LIMITED 58

View Latest Price from AZD1152 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Barasertib pictures 2026-07-27 Barasertib
722543-31-9
 $42.00-118.00 99.92% 10g TargetMol Chemicals Inc.
Barasertib pictures 2026-07-27 Barasertib
722543-31-9
 $42.00-118.00 99.92% 10g TargetMol Chemicals Inc.
  • Barasertib pictures
  • Barasertib
    722543-31-9
  • $42.00-118.00
  • 99.92%
  • TargetMol Chemicals Inc.
  • Barasertib pictures
  • Barasertib
    722543-31-9
  • $42.00-118.00
  • 99.92%
  • TargetMol Chemicals Inc.

AZD1152 Spectrum

AZD1152(722543-31-9)MSAZD1152(722543-31-9)1HNMRAZD1152(722543-31-9)31PNMR

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1H-Pyrazole-3-acetamide, 5-[[7-[3-[ethyl[2-(phosphonooxy)ethyl]amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)- AZD1152 5-[[7-[3-[Ethyl[2-(phosphonooxy)ethyl]amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-1H-pyrazole-3-acetamide BARASERTIB; AZD-1152; AZD 1152 Barasertib (AZD1152) CS-1053 2-[[3-({4-[(5-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-3-yl)amino]quinazolin-7-yl}oxy)propyl](ethyl)amino]ethyl dihydrogen phosphate 2-(Ethyl(3-((4-((3-(2-((3-fluorophenyl)amino)-2-oxoethyl)-1H-pyrazol-5-yl)amino)quinazolin-7-yl)oxy)propyl)amino)ethyl dihydrogen phosphate Barasertib, 10 mM in DMSO 722543-31-9