5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine
- CAS No.
- 1180132-17-5
- Chemical Name:
- 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine
- Synonyms
- Abemaciclib Impurity 4;LY2835219 Intermediate 1;5-[(4-ethyl-1-piperazinyl)methyl]-2-pyridin;5-((4-Ethylpiperazin-1-y)methyDpyridin-2-amine;5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-amin;-((4-Ethylpiperazin-1-yl)Methyl)pyridin-2-aMine;5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine;5-[(4-Ethyl-1-piperazinyl)methyl]-2-pyridinamine;2-Amino-5-[(4-ethyl-1-piperazinyl)methyl]pyridine;5-((4-ethylpiperazin-1-yl)methyl)pyridine-2-amine
- CBNumber:
- CB72500105
- Molecular Formula:
- C12H20N4
- Molecular Weight:
- 220.31
- MDL Number:
- MFCD14706690
- MOL File:
- 1180132-17-5.mol
| Boiling point | 362℃ |
|---|---|
| Density | 1.101 |
| Flash point | 173℃ |
| storage temp. | 2-8°C(protect from light) |
| pka | 7.71±0.10(Predicted) |
| Appearance | White to yellow Solid |
| InChI | InChI=1S/C12H20N4/c1-2-15-5-7-16(8-6-15)10-11-3-4-12(13)14-9-11/h3-4,9H,2,5-8,10H2,1H3,(H2,13,14) |
| InChIKey | MNJBMPQTXVZMFZ-UHFFFAOYSA-N |
| SMILES | C1(N)=NC=C(CN2CCN(CC)CC2)C=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H318-H302 |
| Precautionary statements | P280-P305+P351+P338-P310-P264-P270-P301+P312-P330-P501 |
| HS Code | 2933599590 |
5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | E926858 | 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine | 1180132-17-5 | 100mg | $60 | 2021-12-16 | Buy |
| TRC | E926858 | 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine | 1180132-17-5 | 500mg | $155 | 2021-12-16 | Buy |
| AK Scientific | 2951AA | 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine | 1180132-17-5 | 5g | $195 | 2021-12-16 | Buy |
| Apolloscientific | OR471684 | 2-Amino-5-[(4-ethyl-1-piperazinyl)methyl]pyridine | 1180132-17-5 | 5g | $226 | 2021-12-16 | Buy |
| SynQuest Laboratories | 3H30-1-KV | 2-Amino-5-[(4-ethyl-1-piperazinyl)methyl]pyridine 95% | 1180132-17-5 | 5G | $268 | 2021-12-16 | Buy |
5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine Chemical Properties,Uses,Production
Physical Form
Solid
Uses
5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine is a useful research chemical.
Flammability and Explosibility
Not classified
Synthesis
121-44-8
156973-09-0
1180132-17-5
To a 500 mL four-necked round-bottomed flask equipped with a thermometer and condenser tube were added 100 g of 1,2-dichloroethane, 12.5 g (0.1 mol) of 5-(aminomethyl)pyridin-2-amine (IV) and 30.0 g of potassium carbonate. A solution consisting of 25.0 g (0.15 mol) N,N-diethylethylamine and 20 g of 1,2-dichloroethane was added slowly and dropwise over a period of about 2 hours at 30 to 35 °C. The reaction temperature was maintained at 30~35°C and stirring was continued for 6 hours. After completion of the reaction, it was cooled to 20~25°C and layered. The aqueous layer was extracted twice with 1,2-dichloroethane at 20 g. The organic phases were combined and the 1,2-dichloroethane was removed by distillation. To the residue was added 75 g of methyl tert-butyl ether and 0.5 g of activated charcoal and stirred at 80~82°C for 1 hr. After hot filtration, the filtrate was cooled to 0~5°C for crystallization, filtered and dried to afford 18.2 g of 5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-amine as a white solid in 82.7% yield and 99.3% purity of the liquid phase.
References
[1] Patent: CN107337634, 2017, A. Location in patent: Paragraph 0040; 0053; 0054; 0057; 0058; 0061; 0062
5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Zhonghan Chemical Technology Co., LTD. | +undefined15066662237 | 3281004549@qq.com | China | 291 | 58 |
| Suzhou Victorypharm Co.,Ltd. | +86-13916956214 | sales@victory-pharm.com | China | 1299 | 58 |
| Porton Pharma Solutions Ltd. | China | 56 | 58 | ||
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-17392712697 | 1022@dideu.com | China | 3995 | 58 |
| Yangzhou Qinyuan Pharmatech Co.,ltd | +86-18752526868 +86-18752526868 | jennysun@yzqyyykj.com | China | 83 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20185 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21620 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29852 | 58 |
View Lastest Price from 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-25 | 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine
1180132-17-5
|
US $5.00-0.10 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2025-08-29 | 5-((4-ethylpiperazin-1-yl)methyl)pyridine-2-amine
1180132-17-5
|
US $0.00-0.00 / kg | 1kg | 99% | 1 | Jinan Ruitong Biotech Co., Ltd. | |
 |
2025-07-25 | 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine
1180132-17-5
|
US $0.00 / kg | 1kg | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd |
-
- 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine
1180132-17-5
- US $5.00-0.10 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 5-((4-ethylpiperazin-1-yl)methyl)pyridine-2-amine
1180132-17-5
- US $0.00-0.00 / kg
- 99%
- Jinan Ruitong Biotech Co., Ltd.
-
- 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine
1180132-17-5
- US $0.00 / kg
- 98%
- Shaanxi Dideu New Materials Co. Ltd
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