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ChemicalBook >> CAS DataBase List >>1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid

1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid

1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid Structure
1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid structure
CAS No.
123853-39-4
Chemical Name:
1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid
Synonyms
clevidipine acid;Desethyl Felodipine;Cleviprex Impurity 1;Monomethyl Felodipine;Felodipine Impurity D;4-(2,3-Dichlorophenyl);Intermediate of Clevidipine;levidipine Impurity 1-13C-d3;Desethyl Felodipine USP/EP/BP;Clevidipine Butyrate Impurity1474
CBNumber:
CB72501410
Molecular Formula:
C16H15Cl2NO4
Molecular Weight:
356.2
MDL Number:
MFCD06654363
MOL File:
123853-39-4.mol
MSDS File:
SDS
Last updated:2026-05-28 03:24:34
Product description Number Pack Size Price
Desethyl Felodipine TRC-D289240-50MG 50mg $276
Desethyl Felodipine 163664 50mg $509
Desethyl Felodipine TRC-D289240-500MG 500mg $1983
4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylicacid monomethylester FD152098 25g $900
4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylicacid monomethylester FD152098 1g $900
More product size
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1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid Properties

Melting point 197-200°C
Boiling point 483.0±45.0 °C(Predicted)
Density 1.375±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 1.65±0.70(Predicted)
color Pale Yellow to Pale Beige
FDA UNII 446669RI9H

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid price More Price(39)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC TRC-D289240-50MG Desethyl Felodipine 123853-39-4 50mg $276 2026-06-03 Buy
Usbiological 163664 Desethyl Felodipine 123853-39-4 50mg $509 2026-06-03 Buy
TRC TRC-D289240-500MG Desethyl Felodipine 123853-39-4 500mg $1983 2026-06-03 Buy
Biosynth FD152098 4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylicacid monomethylester 123853-39-4 25g $900 2026-06-04 Buy
Biosynth FD152098 4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylicacid monomethylester 123853-39-4 1g $900 2026-06-04 Buy
Product number Packaging Price Buy
TRC-D289240-50MG 50mg $276 Buy
163664 50mg $509 Buy
TRC-D289240-500MG 500mg $1983 Buy
FD152098 25g $900 Buy
FD152098 1g $900 Buy

1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid Chemical Properties,Uses,Production

Uses

Desethyl Felodipine is an impurity in the synthesis of Felodipine (F232375), a dihydropyridine calcium channel blocker.

Synthesis

4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-cyano-ethyl) ester 5-methyl ester

110962-94-2

1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid

123853-39-4

The general procedure for the synthesis of 4-(2,3-dichlorophenyl)-5-(methoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid, using 3-(2-cyanoethyl) 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3-dicarboxylate as a starting material, was as follows: in a three-necked flask equipped with a stirrer, add 400 g of Intermediate II and 2 L of isopropanol and stirred until completely dissolved. Subsequently, 30 g of potassium hydroxide and 10 g of triethylbenzyl ammonium bromide were added, heated to 80 °C and stirred at reflux for 5 to 6 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was filtered. The filtrate was concentrated to dryness under reduced pressure. To the dried residue, 2 L of dichloromethane and 2 L of water were added, stirred for 10 minutes and left to stratify. Dilute hydrochloric acid was slowly added dropwise to the aqueous phase under ice bath conditions to adjust the pH to 4.5 and stirring was continued for 1 hour. Subsequently, filtration was carried out and the filter cake was washed with pure water to pH=7. After drying, 260 g of product was obtained and the purity was 96.11% by HPLC. In another reaction flask, 130 g of crude intermediate butyl clovedipine and 650 ml of ethyl acetate were added, stirred and heated to 40 °C, maintained for 10 min and then hot filtered. The filter cake was dried to give 122 g of pale yellow solid, the important intermediate clovidipine butyrate. The purity was 99.09% and the yield was 93% by HPLC. The total yield of the present synthesis method was 53%, which gave an important intermediate of clovidipine butyrate acid with high purity.

References

[1] Chemical and Pharmaceutical Bulletin, 1994, vol. 42, # 8, p. 1579 - 1589
[2] Chemical and Pharmaceutical Bulletin, 1993, vol. 41, # 1, p. 108 - 116
[3] Patent: CN105367487, 2016, A. Location in patent: Paragraph 0021
[4] Patent: CN103242220, 2016, B. Location in patent: Paragraph 0040; 0051-0052

1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid synthesis

91189-59-2
123853-39-4
Synthesis of 1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid from Felodipine 3,5-DiMethyl Ester

1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid Preparation Products And Raw materials

Raw materials

4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-cyano-ethyl) ester 5-methyl ester Felodipine 3,5-DiMethyl Ester Methyl 2-(2,3-dichlorobenzylidine)acetoacetate Cleviprex Impurity J 2,3-Dichlorobenzaldehyde
Isopropyl alcohol Potassium hydroxide Benzyltriethylammonium bromide

1of2

Preparation Products

4-(2,3-Dichlorophenyl)-2,6-diMethyl-1,4-dihydropyridine-3,5-dicarboxylic acid

1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid Suppliers

Global( 86)Suppliers
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Jinan Finer Chemical Co., Ltd 		+86-531-88989536 +86-15508631887 sales@finerchem.com China 2950 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19936 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29792 58
Shaanxi Dideu Medichem Co. Ltd 		+86-029-89586680 +86-18192503167 1026@dideu.com China 9996 58
Hangzhou Huarong Pharm Co., Ltd. 		571-86758373 +8613588754946 sales@huarongpharm.com CHINA 3148 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Aladdin Scientific 		tp@aladdinsci.com United States 52923 58
Shenzhen Nexcon Pharmatechs Ltd. 		+86-0755-89396905 +86-18025329037 admin@nexconn.com China 5281 58
DAYANG CHEM (HANGZHOU) CO.,LTD 		+86-88938639 +86-17705817739 info@dycnchem.com China 53803 58
Sinco Pharmachem (ShenZhen) R&D Co., Ltd. 		+undefined18603013401 jack.lin@sincopharmachem.com China 9996 58
Supplier Advantage
Jinan Finer Chemical Co., Ltd 		58
BOC Sciences 		58
career henan chemical co 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Hangzhou Huarong Pharm Co., Ltd. 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58
Aladdin Scientific 		58
Shenzhen Nexcon Pharmatechs Ltd. 		58
DAYANG CHEM (HANGZHOU) CO.,LTD 		58
Sinco Pharmachem (ShenZhen) R&D Co., Ltd. 		58

View Lastest Price from 1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid pictures 2020-05-10 1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid
123853-39-4
 1KG 99.0% 500 MT Shaanxi Dideu Medichem Co. Ltd
1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid pictures 2020-01-17 1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid
123853-39-4
 $1.00 1KG 85.0-99.8% 200kgs Career Henan Chemical Co

1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid Spectrum

1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid(123853-39-4)1HNMR

123853-39-4(1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid)Related Search:

Chlorhexidine digluconate 3-((butyryloxy)Methyl) 5-Methyl 4-(2',3'-dichlorophenyl)-2,6-diMethylpyridine-3,5-dicarboxylate 4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-cyano-ethyl) ester 5-methyl ester Clevidipine butyrate Clevidipine
1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-diMethyl-, 3-Methyl ester Desethyl Felodipine 1,4-Dihydro-2,6-diMethyl-4-(2',3'-dichlorophenyl)-5-carboxy Meth 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid monomethyl ester 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3-methyl ester Monomethyl Felodipine -2,6-dimethyl-1,4-dihydropyridine-3-carboxylic acid 4-(2,3-Dichlorophenyl) Cleviprex Impurity 1 Intermediate of Clevidipine levidipine Impurity 1-13C-d3 Desethyl Felodipine USP/EP/BP 1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid USP/EP/BP 4-(2,3-Dichlorophenyl)-5-(methoxycarbonyl)-2,6-dimethyl-1,4-dihyd ro-3-pyridinecarboxylic acid Clevidipine Butyrate Impurity1474 clevidipine acid Felodipine Impurity D 1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxymethylpyridin-3-carboxylic acid 123853-39-4