1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid
- CAS No.
- 123853-39-4
- Chemical Name:
- 1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid
- Synonyms
- clevidipine acid;Desethyl Felodipine;Cleviprex Impurity 1;Monomethyl Felodipine;Felodipine Impurity D;4-(2,3-Dichlorophenyl);Intermediate of Clevidipine;levidipine Impurity 1-13C-d3;Desethyl Felodipine USP/EP/BP;Clevidipine Mono Acid impurity
- CBNumber:
- CB72501410
- Molecular Formula:
- C16H15Cl2NO4
- Molecular Weight:
- 356.2
- MDL Number:
- MFCD06654363
- MOL File:
- 123853-39-4.mol
- MSDS File:
- SDS
1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid Properties
| Melting point | 197-200°C |
|---|---|
| Boiling point | 483.0±45.0 °C(Predicted) |
| Density | 1.375±0.06 g/cm3 (20 ºC 760 Torr) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 1.65±0.70(Predicted) |
| color | Pale Yellow to Pale Beige |
| FDA UNII | 446669RI9H |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-D289240-50MG | Desethyl Felodipine | 123853-39-4 | 50mg | $276 | 2026-06-03 | Buy |
| Usbiological | 163664 | Desethyl Felodipine | 123853-39-4 | 50mg | $509 | 2026-06-03 | Buy |
| TRC | TRC-D289240-500MG | Desethyl Felodipine | 123853-39-4 | 500mg | $1983 | 2026-06-03 | Buy |
| Biosynth | FD152098 | 4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylicacid monomethylester | 123853-39-4 | 25g | $900 | 2026-06-04 | Buy |
| Biosynth | FD152098 | 4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylicacid monomethylester | 123853-39-4 | 1g | $900 | 2026-06-04 | Buy |
1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid Chemical Properties, Uses, Production
Uses
Desethyl Felodipine is an impurity in the synthesis of Felodipine (F232375), a dihydropyridine calcium channel blocker.
Synthesis
110962-94-2
123853-39-4
The general procedure for the synthesis of 4-(2,3-dichlorophenyl)-5-(methoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid, using 3-(2-cyanoethyl) 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3-dicarboxylate as a starting material, was as follows: in a three-necked flask equipped with a stirrer, add 400 g of Intermediate II and 2 L of isopropanol and stirred until completely dissolved. Subsequently, 30 g of potassium hydroxide and 10 g of triethylbenzyl ammonium bromide were added, heated to 80 °C and stirred at reflux for 5 to 6 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was filtered. The filtrate was concentrated to dryness under reduced pressure. To the dried residue, 2 L of dichloromethane and 2 L of water were added, stirred for 10 minutes and left to stratify. Dilute hydrochloric acid was slowly added dropwise to the aqueous phase under ice bath conditions to adjust the pH to 4.5 and stirring was continued for 1 hour. Subsequently, filtration was carried out and the filter cake was washed with pure water to pH=7. After drying, 260 g of product was obtained and the purity was 96.11% by HPLC. In another reaction flask, 130 g of crude intermediate butyl clovedipine and 650 ml of ethyl acetate were added, stirred and heated to 40 °C, maintained for 10 min and then hot filtered. The filter cake was dried to give 122 g of pale yellow solid, the important intermediate clovidipine butyrate. The purity was 99.09% and the yield was 93% by HPLC. The total yield of the present synthesis method was 53%, which gave an important intermediate of clovidipine butyrate acid with high purity.
References
[1] Chemical and Pharmaceutical Bulletin, 1994, vol. 42, # 8, p. 1579 - 1589
[2] Chemical and Pharmaceutical Bulletin, 1993, vol. 41, # 1, p. 108 - 116
[3] Patent: CN105367487, 2016, A. Location in patent: Paragraph 0021
[4] Patent: CN103242220, 2016, B. Location in patent: Paragraph 0040; 0051-0052
1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shandong Kehui Pharmaceutical Co. LTD | 0531-68651908; 13276409687 | 469553953@qq.com | China | 38 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16306 | 64 |
| Daicel Chiral Technologies (China)CO.,LTD | 021-50460086-9 15921403865 | han_yajun@dctc.daicel.com | China | 7917 | 65 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Chengdu Huide Pharmaceutical Technology Co., Ltd. | 028-85143709 18086827605,13880755258 | Tinleycd@163.com | China | 44 | 55 |
| Jinan Kaypharm Chemical Co.,Ltd. | 0531-86986780 13153183025; | sales@kaypharm.cn | China | 109 | 55 |
View Latest Price from 1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-05-10 | 1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid
123853-39-4
|
1KG | 99.0% | 500 MT | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2020-01-17 | 1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid
123853-39-4
|
$1.00 | 1KG | 85.0-99.8% | 200kgs | Career Henan Chemical Co |
-
- 1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid
123853-39-4
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- 1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid
123853-39-4
- $1.00
- 85.0-99.8%
- Career Henan Chemical Co
