BIO 1211
- CAS No.
- 187735-94-0
- Chemical Name:
- BIO 1211
- Synonyms
- BIO 1211;inhibit,BIO1211,BIO-1211,Integrin,BIO 1211,Inhibitor;L-Proline, N-[2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl]-L-leucyl-L-α-aspartyl-L-valyl-;(2S)-1-[(2S)-2-[[(2S)-3-carboxy-2-[[(2S)-4-methyl-2-[[2-[4-[(2-methylphenyl)carbamoylamino]phenyl]acetyl]amino]pentanoyl]amino]propanoyl]amino]-3-methylbutanoyl]pyrrolidine-2-carboxylicacid
- CBNumber:
- CB72518836
- Molecular Formula:
- C36H48N6O9
- Molecular Weight:
- 708.81
- MDL Number:
- MFCD02259692
- MOL File:
- 187735-94-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| BIO 1211 Asreported | 254769 | 1mg | $423 |
| (4-((2-Methylphenyl)aminocarbonyl)-aminophenyl)acetyl-Fibronectin CS-1 Fragment (1980-1983) | FM111090 | 2mg | $900 |
| (4-((2-Methylphenyl)aminocarbonyl)-aminophenyl)acetyl-Fibronectin CS-1 Fragment (1980-1983) | FM111090 | 1mg | $900 |
| (4-((2-Methylphenyl)aminocarbonyl)-aminophenyl)acetyl-Fibronectin CS-1 Fragment (1980-1983) | FM111090 | 5mg | $989.5 |
| (4-((2-Methylphenyl)aminocarbonyl)-aminophenyl)acetyl-Fibronectin CS-1 Fragment (1980-1983) | FM111090 | 10mg | $1709.2 |
| Boiling point | 962.2±65.0 °C(Predicted) |
|---|---|
| Density | 1.306±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble to 2 mg/ml in 0.2M PBS |
| form | solid |
| pka | 3.40±0.20(Predicted) |
| color | White |
| Water Solubility | Soluble to 2 mg/ml in water |
| InChIKey | NVVGCQABIHSJSQ-KFZSMJGVSA-N |
| SMILES | N3([C@@H](CCC3)C(=O)O)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)Cc1ccc(cc1)NC(=O)Nc2c(cccc2)C)CC(C)C)CC(=O)O)C(C)C |
| FDA UNII | 61G4E2353I |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
BIO 1211 price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 254769 | BIO 1211 Asreported | 187735-94-0 | 1mg | $423 | 2026-06-03 | Buy |
| Biosynth | FM111090 | (4-((2-Methylphenyl)aminocarbonyl)-aminophenyl)acetyl-Fibronectin CS-1 Fragment (1980-1983) | 187735-94-0 | 2mg | $900 | 2026-06-04 | Buy |
| Biosynth | FM111090 | (4-((2-Methylphenyl)aminocarbonyl)-aminophenyl)acetyl-Fibronectin CS-1 Fragment (1980-1983) | 187735-94-0 | 1mg | $900 | 2026-06-04 | Buy |
| Biosynth | FM111090 | (4-((2-Methylphenyl)aminocarbonyl)-aminophenyl)acetyl-Fibronectin CS-1 Fragment (1980-1983) | 187735-94-0 | 5mg | $989.5 | 2026-06-04 | Buy |
| Biosynth | FM111090 | (4-((2-Methylphenyl)aminocarbonyl)-aminophenyl)acetyl-Fibronectin CS-1 Fragment (1980-1983) | 187735-94-0 | 10mg | $1709.2 | 2026-06-04 | Buy |
BIO 1211 Chemical Properties,Uses,Production
Uses
BIO 1211 is a selective, high affinity α4β1 (VLA-4) inhibitor.
Biological Activity
BIO 1211 is a selective, tight-binding α4β1 (VLA-4, very late antigen-4; koff = 1.4 x 10-4/s, KD = 70 pM) integrin antagonist (VCAM-Ig Jurk at surface binding IC50 = 1 nM; integrin-mediated cell adhesion IC50 = 4 nM/α4β1, 2 μM/α4β7, >100 μM/α1β1, α5β1, α6β1, αLβ2, αIIBβ3) based on the Leu-Asp-Val (LDV) sequence from the alternatively spliced connecting segment-1 (CS-1) of fibronectin (aa 1980-1983). In addition to probing α4β1-mediated cellular responses, BIO 1211 is also widely used in animal disease models in vivo, including MS (5-10 mg/kg; murine EAE) and asthma (1-10 mg/kg via intranasal or nebulizer to mice, rats, sheep; 3 mg/sheep iv.).
in vivo
BIO-1211 (5 and 10 mg/kg, orally, once every other day) results in reduced cytokines expression, leukocyte trafficking, and inhibition of inflammatory responses in EAE in a dose-independent manner. BIO-1211 exhibits a considerable depletion in the EAE clinical score, which correlated with decreased expression of TNF-α, IL-17, IFN-γ and pervade of CD11b+ and CD45+ cells into the cerebral cortex[2].
| Animal Model: | Naive, C57BL/6 mice (male, 8 weeks old, 20-25 g weight)[2]. |
| Dosage: | 5 and 10 mg/kg. |
| Administration: | Orally once every other day starting the day before immunization until day 21 post-immunization. |
| Result: | Could prevent the induction of EAE. Significantly delayed the onset of EAE and reduced the severity of clinical EAE compared to the vehicle group. Markedly reduced the expression of both CD11b and CD45 in comparison with the vehicle group. mRNA and soluble form of a subset of target inflammatory cytokines (IFNγ, IL-17, and TNF-α) was dramatically decreased. |
IC 50
α4β1: 4 nM (IC50); α4β7: 2 μM (IC50)
storage
Store at -20°C
BIO 1211 Preparation Products And Raw materials
Raw materials
Preparation Products
BIO 1211 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10378 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 54746 | 58 | |
| ANHUI BYERSEN BIOTECH CO. LTD | +86-15385096007 +86-17755058861 | amy@byersenchemical.com | China | 9886 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 17801761073 18101056239 | 3193328036@qq.com | China | 28150 | 68 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 15967184799 | Eric@peptidego.com | China | 7872 | 58 |
| Wuxi Helen Biotechnology Co., Ltd., | 0510-85629785 18013409632 | sales@reading-chemicals.com | China | 14072 | 58 |
| Nanjing TGpeptide Biotechnology Co.,Ltd. | 18115476705 | sales@tgpeptide.com | China | 3058 | 58 |
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