ChemicalBook >> CAS DataBase List >>2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine

2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine

2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine structure

CAS No.: 500579-04-4

Chemical Name:: 2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine

Synonyms: GNT61;CS-867;GANT 61;NSC 136476;GANT61, >=98%;GANT61 ，S8075;GANT-61,NSC 136476;GANT 61, 10 mM in DMSO;GANT61;GANT 61;NSC 136476;Hh/Gli Antagonist, GANT61

CBNumber:: CB72518922

Molecular Formula:: C27H35N5

Molecular Weight:: 429.6

MDL Number:: MFCD14635408

MOL File:: 500579-04-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-27 17:00:41

Product description	Number	Pack Size	Price
GANT61 ≥98% (HPLC)	G9048	5mg	$208
InSolution? Hh/Gli Antagonist, GANT61	373403	2mg	$105
GANT 61 ≥98%	13841	5mg	$65
GANT 61 ≥98%	13841	10mg	$117
GANT 61 ≥98%	13841	25mg	$260
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2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine Properties

Melting point	110 - 113°C
Boiling point	549.0±50.0 °C(Predicted)
Density	1.134±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: >2mg/mL
pka	5.97±0.10(Predicted)
form	powder
color	white to off-white
InChI	1S/C27H35N5/c1-29(2)25-12-7-5-10-23(25)20-31-18-9-19-32(27(31)22-14-16-28-17-15-22)21-24-11-6-8-13-26(24)30(3)4/h5-8,10-17,27H,9,18-21H2,1-4H3
InChIKey	KVQOGDQTWWCZFX-UHFFFAOYSA-N
SMILES	N2(C(N(CCC2)Cc4c(cccc4)N(C)C)c3ccncc3)Cc1c(cccc1)N(C)C
UNSPSC Code	51111800
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H319
Precautionary statements	P305+P351+P338
WGK Germany	3
HS Code	29349990
Storage Class	11 - Combustible Solids

2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine price More Price(76)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	G9048	GANT61 ≥98% (HPLC)	500579-04-4	5mg	$208	2026-04-30	Buy
Sigma-Aldrich	373403	InSolution? Hh/Gli Antagonist, GANT61	500579-04-4	2mg	$105	2026-04-30	Buy
Cayman Chemical	13841	GANT 61 ≥98%	500579-04-4	5mg	$65	2026-04-30	Buy
Cayman Chemical	13841	GANT 61 ≥98%	500579-04-4	10mg	$117	2026-04-30	Buy
Cayman Chemical	13841	GANT 61 ≥98%	500579-04-4	25mg	$260	2026-04-30	Buy

Product number	Packaging	Price	Buy
G9048	5mg	$208	Buy
373403	2mg	$105	Buy
13841	5mg	$65	Buy
13841	10mg	$117	Buy
13841	25mg	$260	Buy

2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine Chemical Properties,Uses,Production

Uses

GANT61 is an inhibitor for GLI1 as well as GLI2-induced transcription, inhibits hedgehog, displays selectivity over other pathways, such as TNF and glucocorticoid receptor gene transactivation.

Definition

ChEBI: GANT61 is an aminal that is hexahydropyrimidine which is substituted on each nitrogen by a 2-(dimethylamino)benzyl group, and at the aminal carbon by a pyridin-4-yl group. A Hedgehog signaling pathway and Gli protein inhibitor. It has a role as a Hedgehog signaling pathway inhibitor, a glioma-associated oncogene inhibitor, an antineoplastic agent and an apoptosis inducer. It is a tertiary amino compound, a member of pyridines, a substituted aniline and an aminal.

Biochem/physiol Actions

GANT61 blocks hedgehog pathway signaling by inhibiting the transcripional activity of Gli1 (IC50 = 5 μM). GANT 61 led to a regression of 22Rv1 human prostate tumor cell xenografts in nude mice.

in vivo

GANT-61 (40 mg/kg, i.p., three days per week) inhibits CSC tumor growth in NOD/SCID IL2Rγ null mice^[2]. GANT61 (50 mg/kg, p.o.) enhances the effects of chemotherapeutic drugs used in the treatment of neuroblastoma in an additive or synergistic manner and reduces the growth of established neuroblastoma xenografts in nude mice^[3].

storage

+4°C

2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine Preparation Products And Raw materials

Raw materials

Preparation Products

2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine Suppliers

Global( 181)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32997	60
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	963	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19935	58
career henan chemical co	+86-0371-86658258	factory@coreychem.com	China	29780	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1059@dideu.com	China	29096	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471	sales@sarms4muscle.com	China	10378	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6378	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	38999	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11674	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Biochempartner	58
BOC Sciences	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
TargetMol Chemicals Inc.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58

View Lastest Price from 2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-07-27	GANT 61 500579-04-4	$33.00-81.00		97.59%	10g	TargetMol Chemicals Inc.
	2019-12-23	2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine 500579-04-4	$1.00	100ASSAYS	98%min		Career Henan Chemical Co

GANT 61
500579-04-4
$33.00-81.00
97.59%
TargetMol Chemicals Inc.

2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine
500579-04-4
$1.00
98%min
Career Henan Chemical Co

2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine Spectrum

2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine(500579-04-4)¹HNMR

500579-04-4(2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine)Related Search:

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SANT-1

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2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine GANT 61 Benzenamine, 2,2'-[[dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethyl- 2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine] GANT61 GNT61 NSC 136476 InSolution Hh/Gli Antagonist, GANT61 - CAS 500579-04-4 - Calbiochem CS-867 GANT61; GANT-61; NSC 136476;GANT 61 GANT61;GANT 61;NSC 136476 GANT61, >=98% GANT-61,NSC 136476 2,2'-((2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(N,N-dimethylanilin InSolution? Hh/Gli Antagonist, GANT61 2-[[3-[[2-(dimethylamino)phenyl]methyl]-2-pyridin-4-yl-1,3-diazinan-1-yl]methyl]-N,N-dimethylaniline 2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine USP/EP/BP 2,2'-((2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(N,N-dimethylaniline) 2,2’-[[2-(4-Pyridyl)dihydropyrimidine-1,3(2H,4H)-diyl]bis(methylene)]bis(N,N-dimethylaniline) GANT 61, GLI1 and 2 inhibitor GANT 61, 10 mM in DMSO Hh/Gli Antagonist, GANT61 GANT61 ，S8075 2,2'-[[Dihydro-2-pyridin-4-yl-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethyl-aniline 500579-04-4 C27H35N5 Inhibitors