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ChemicalBook >> CAS DataBase List >>5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one

5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one

5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one Structure
5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one structure
CAS No.
768404-03-1
Chemical Name:
5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one
Synonyms
5-BDBD;5-BDBD, 10 mM in DMSO;5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one;5-(3-bromophenyl)-1,3-dihydro-[1]benzofuro[3,2-e][1,4]diazepin-2-one;2H-Benzofuro[3,2-e]-1,4-diazepin-2-one, 5-(3-bromophenyl)-1,3-dihydro-;inhibit,P2X Receptor,5-BDBD,P2XRs,currents,NTG,hyperalgesia,selective,Inhibitor,ATP,5BDBD,acute,5 BDBD
CBNumber:
CB72518942
Molecular Formula:
C17H11BrN2O2
Molecular Weight:
355.19
MDL Number:
MFCD18086878
MOL File:
768404-03-1.mol
MSDS File:
SDS
Last updated:2025-07-04 15:24:38
Product description Number Pack Size Price
5-BDBD ≥98% (HPLC) SML0450 5mg $118.75
5-BDBD ≥98% (HPLC) SML0450 25mg $353.5
5-BDBD ≥99%(HPLC) 3579 10 $197
5-BDBD ≥99%(HPLC) 3579 50 $847
5-BDBD B129503 25mg $1320
Request For Quotation

5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one Properties

storage temp. 2-8°C
solubility DMSO: soluble15mg/mL (clear solution)
form powder
color white to beige
InChI InChI=1S/C17H11BrN2O2/c18-11-5-3-4-10(8-11)15-17-16(20-14(21)9-19-15)12-6-1-2-7-13(12)22-17/h1-8H,9H2,(H,20,21)
InChIKey NKYMVQPXXTZHSF-UHFFFAOYSA-N
SMILES N1=C(C2=CC=CC(Br)=C2)C2OC3=CC=CC=C3C=2NC(=O)C1
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3

5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0450 5-BDBD ≥98% (HPLC) 768404-03-1 5mg $118.75 2025-07-31 Buy
Sigma-Aldrich SML0450 5-BDBD ≥98% (HPLC) 768404-03-1 25mg $353.5 2025-07-31 Buy
Tocris 3579 5-BDBD ≥99%(HPLC) 768404-03-1 10 $197 2021-12-16 Buy
Tocris 3579 5-BDBD ≥99%(HPLC) 768404-03-1 50 $847 2021-12-16 Buy
TRC B129503 5-BDBD 768404-03-1 25mg $1320 2021-12-16 Buy
Product number Packaging Price Buy
SML0450 5mg $118.75 Buy
SML0450 25mg $353.5 Buy
3579 10 $197 Buy
3579 50 $847 Buy
B129503 25mg $1320 Buy

5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one Chemical Properties,Uses,Production

Uses

5-BDBD is a potent P2X4 receptor antagonist.

Biochem/physiol Actions

5-BDBD is a specific inhibitor of P2X4. The compound inhibits P2X4 currents in CHO cells with an IC50 of 500 nM.

in vivo

5-BDBD (28 mg/kg; i.p.; daily for 9 days) can completely blocke the basal hyperalgesia induced by recurrent NTG injection[2].

Animal Model:Male C57BL/6 mice[2]
Dosage:28 mg/kg
Administration:I.p.; daily for 9 days
Result:Prevented NTG-induced mechanical hypersensitivity.

IC 50

P2X4 Receptor

storage

Store at RT

5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one Suppliers

Global( 64)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32434 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3135 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139 orders@jknbiochem.com China 5221 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15839 69
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 12952 65
Bide Pharmatech Ltd. 400-164-7117 13681763483 product02@bidepharm.com China 42446 60
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51395 80
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4667 55
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8447 60
Supplier Advantage
TargetMol Chemicals Inc. 		58
Nantong HI-FUTURE Biology Co., Ltd. 		58
Aladdin Scientific 		58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		58
3B Pharmachem (Wuhan) International Co.,Ltd. 69
BOC Sciences 65
Bide Pharmatech Ltd. 60
Sigma-Aldrich 80
Shanghai Lollane Biological Technology Co.,Ltd. 55
EMMX Biotechnology LLC 60

5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one Spectrum

5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one(768404-03-1)1HNMR
5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one 5-BDBD 2H-Benzofuro[3,2-e]-1,4-diazepin-2-one, 5-(3-bromophenyl)-1,3-dihydro- inhibit,P2X Receptor,5-BDBD,P2XRs,currents,NTG,hyperalgesia,selective,Inhibitor,ATP,5BDBD,acute,5 BDBD 5-BDBD, 10 mM in DMSO 5-(3-bromophenyl)-1,3-dihydro-[1]benzofuro[3,2-e][1,4]diazepin-2-one 768404-03-1 C17H11BrN2O2