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HS-PEG4-CH2CH2COOH

HS-PEG4-CH2CH2COOH structure

CAS No.: 749247-06-1

Chemical Name:: HS-PEG4-CH2CH2COOH

Synonyms: SH-PEG4-COOH;HS-PEG4-COOH;1-Mercapto-3,6,9,12-tetraoxapentadecan-15-oic acid;SH-PEG4-PA;HS-PEG4-PA;Thiol-PEG5-acid;Thiol-PEG4-acid;Thiol-dPEG 4 acid;Thiol-dPEG??-acid;HS-PEG-COOH(PEG)4

CBNumber:: CB72546907

Molecular Formula:: C11H22O6S

Molecular Weight:: 282.35

MDL Number:: MFCD11041132

MOL File:: 749247-06-1.mol

MSDS File:: SDS

Last updated:2026-05-28 03:57:36

Product description	Number	Pack Size	Price
Bis-dPEG®5-NHS Ester	DPG-6022	100mg	$248
Bis-dPEG®5-NHS Ester	DPG-6022	1000mg	$720
Thiol-dPEG®4-Acid	DPG-5735	100mg	$286
Thiol-dPEG®4-Acid	DPG-5735	1000mg	$1650
HS-PEG4-CH2CH2COOH	282702-5G	5g	$1433
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HS-PEG4-CH2CH2COOH Properties

Boiling point	422.9±45.0 °C(Predicted)
Density	1.156±0.06 g/cm3(Predicted)
storage temp.	-20°C
pka	4.28±0.10(Predicted)
form	Liquid
color	Colorless to light yellow
UNSPSC Code	12352106
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P332+P313-P337+P313-P362-P403+P233-P405-P501
HS Code	2930909899

HS-PEG4-CH2CH2COOH price More Price(55)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Biosynth	DPG-6022	Bis-dPEG®5-NHS Ester	749247-06-1	100mg	$248	2026-06-04	Buy
Biosynth	DPG-6022	Bis-dPEG®5-NHS Ester	749247-06-1	1000mg	$720	2026-06-04	Buy
Biosynth	DPG-5735	Thiol-dPEG®4-Acid	749247-06-1	100mg	$286	2026-06-04	Buy
Biosynth	DPG-5735	Thiol-dPEG®4-Acid	749247-06-1	1000mg	$1650	2026-06-04	Buy
ChemPep	282702-5G	HS-PEG4-CH2CH2COOH	749247-06-1	5g	$1433	2026-06-04	Buy

Product number	Packaging	Price	Buy
DPG-6022	100mg	$248	Buy
DPG-6022	1000mg	$720	Buy
DPG-5735	100mg	$286	Buy
DPG-5735	1000mg	$1650	Buy
282702-5G	5g	$1433	Buy

HS-PEG4-CH2CH2COOH Chemical Properties,Uses,Production

Description

Thiol-PEG4-acid is a PEG linker containing a thiol group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Uses

Thiol-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

reaction suitability

reaction type: Pegylations

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

HS-PEG4-CH2CH2COOH Preparation Products And Raw materials

Raw materials

Preparation Products

HS-PEG4-CH2CH2COOH Suppliers

Global( 83)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
9i LLC	+18039569191	MWan@NiNeiLab.com	United States	418	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5742	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58
Wuhan Borenpharm Co., Ltd	027-65563561 18717150066	3207347307@qq.com	CHINA	1238	58
XIAMEN SINOPEG BIOTECH CO., LTD.	+86-0592-7761068 +8617350879715	changaiwei@sinopeg.com	China	1125	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19908	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39039	58
Jilin Chinese Academy of Sciences-yanshen Technology	+undefined18143011203	info@chemextension.com	China	42056	58
Xian confluore Biological Technology Co., Ltd.	+86-15680926068	1924344760@confluore.cn	China	2997	58

Supplier	Advantage
9i LLC	58
career henan chemical co	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
TargetMol Chemicals Inc.	58
Wuhan Borenpharm Co., Ltd	58
XIAMEN SINOPEG BIOTECH CO., LTD.	58
Nextpeptide Inc	58
TargetMol Chemicals Inc.	58
Jilin Chinese Academy of Sciences-yanshen Technology	58
Xian confluore Biological Technology Co., Ltd.	58

View Lastest Price from HS-PEG4-CH2CH2COOH manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-11	Thiol-PEG4-acid 749247-06-1				10g	TargetMol Chemicals Inc.
2025-06-07	Thiol-PEG4-acid 749247-06-1		1g	>98.00%	1g	Xian confluore Biological Technology Co., Ltd.
2020-01-10	HS-PEG4-CH2CH2COOH 749247-06-1	$1.00	1g	99.0%	100kg	Career Henan Chemical Co

Thiol-PEG4-acid
749247-06-1
$0.00
TargetMol Chemicals Inc.

Thiol-PEG4-acid
749247-06-1
$0.00
>98.00%
Xian confluore Biological Technology Co., Ltd.

HS-PEG4-CH2CH2COOH
749247-06-1
$1.00
99.0%
Career Henan Chemical Co

HS-PEG4-CH2CH2COOH Spectrum

HS-PEG4-CH2CH2COOH(749247-06-1)¹HNMR

749247-06-1(HS-PEG4-CH2CH2COOH)Related Search:

Propargyl-PEG4-thiol HS-PEG4-tBu DECAETHYLENE GLYCOL MONOMETHYL ETHER N3-PEG6-tBu 2,5,8,11,14,17,20,23,26,29,32,35-Dodecaoxaheptatriacontan-37-amine

Z-9-aMino-4,7-dioxanonanoic acid alpha-aMine-oMega-propionic acid octaethylene glycol 2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-amine H2N-PEG24-tBu 2-[2-(2-AMINOETHOXY)ETHOXY]ETHANOL

MPEG16-NH2 O-(2-AMINOETHYL)-O-(2-AZIDOETHYL)HEPTAETHYLENE GLYCOL H2N-PEG8-tBu PENTAETHYLENE GLYCOL MONOMETHYL ETHER 2,5,8,11,14,17-Hexaoxanonadecan-19-amine

TETRAETHYLENEGLYCOL MONOMETHYL ETHER alpha-MaleiMidopropionyl-oMega-succiniMidyl-6(ethylene glycol) Amino-PEG4-acid

1of4

HS-PEG4-CH2CH2COOH 3-[2-[2-[2-(2-sulfanylethoxy)ethoxy]ethoxy]ethoxy]propanoic acid Thiol-dPEG 4 acid Propanoicacid, 3-[2-[2-[2-(2-Mercaptoethoxy)ethoxy]ethoxy]ethoxy]- HS-PEG₄-CH₂CH₂COOH Thiol-PEG4-acid Thiol-PEG5-acid Thiol-PEG4-propionic acid HS-PEG-COOH(PEG)4 Thiol-dPEG??-acid HS-PEG?-CH?CH?COOH 4,7,10,13-Tetraoxapentadecanoic acid, 15-mercapto- Thiol-dPEG??-acid (QBD-10247) SH-PEG4-PA HS-PEG4-PA 1-Mercapto-3,6,9,12-tetraoxapentadecan-15-oic acid HS-PEG4-COOH SH-PEG4-COOH 749247-06-1 peg