Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)-
- CAS No.
- 168682-53-9
- Chemical Name:
- Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)-
- Synonyms
- CS-1110;Ezatiostat;Terrapin 199;Ezatiostat, >96%;Ezatiostat, >=98%;TER199(free base);Ezatiostat (TER199);Ezatiostat salt free;Ezatiostat 168682-53-9;Ezatiostat, 10 mM in DMSO
- CBNumber:
- CB72563432
- Molecular Formula:
- C27H35N3O6S
- Molecular Weight:
- 529.65
- MDL Number:
- MFCD27982957
- MOL File:
- 168682-53-9.mol
Melting point | >94°C (dec.) |
---|---|
Boiling point | 749.7±60.0 °C(Predicted) |
Density | 1.216±0.06 g/cm3(Predicted) |
storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
solubility | DMSO (Slightly), Methanol (Slightly) |
pka | 12?+-.0.46(Predicted) |
form | Solid |
color | White to Off-White |
InChIKey | FXTMNDVNPLUYKX-OKIYALLLNA-N |
SMILES | C(OCC)(=O)[C@@H](C1=CC=CC(CC)=C1)N(C(=O)CC[C@@H](C(O)=O)N)C(=O)[C@H](CSCC1=CC=CC=C1)N |&1:5,19,26,r| |
FDA UNII | 057D10I8S8 |
UNSPSC Code | 12352200 |
NACRES | NA.77 |
Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)- price More Price(25)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML1081 | Ezatiostat ≥98% (HPLC) | 168682-53-9 | 5 mg | $136 | 2025-07-31 | Buy |
Sigma-Aldrich | SML1081 | Ezatiostat ≥98% (HPLC) | 168682-53-9 | 25 mg | $550 | 2025-07-31 | Buy |
Cayman Chemical | 16248 | Ezatiostat ≥98% | 168682-53-9 | 1mg | $32 | 2024-03-01 | Buy |
Cayman Chemical | 16248 | Ezatiostat ≥98% | 168682-53-9 | 5mg | $109 | 2024-03-01 | Buy |
Cayman Chemical | 16248 | Ezatiostat ≥98% | 168682-53-9 | 10mg | $199 | 2024-03-01 | Buy |
Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)- Chemical Properties,Uses,Production
Description
Ezatiostat is an inhibitor of glutathione S-transferase pi 1-1 (GSTP1-1; Ki = 0.4 μM). It is selective for GSTP1-1 over GSTα and GSTμ family GSTs (Kis = 20-75 μM). Ezatiostat also inhibits the protein-protein interaction between GSTP1-1 and JNK1. In vivo, ezatiostat (75 mg/kg) increases the number of circulating white blood cells in Gstp1 wild-type, but not Gstp1-/-, mice.
Uses
Ezatiostat is a tripeptide analog of glutathione that can selectively inhibit GSTP1-1, the most prevalent Glutathione S-transferases (GST) isozyme in nonhepatic tissues, catalytic activity with minimal effect on the related GSTα and -μ families.
in vivo
Administration of Ezatiostat (TLK199), stimulates both lymphocyte production and bone marrow progenitor (colony-forming unit-granulocyte macrophage) proliferation, but only in glutathione S-transferase P1-1 (GSTP1+/+) and not in GSTP1-/-animals[2].
target
Gutathione S-transferase
Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)- Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
Shanghai Longyu Biotechnology Co., Ltd. | +8619521488211 | info@longyupharma.com | China | 2556 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29804 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32376 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
LEAP CHEM CO., LTD. | +86-852-30606658 19957148339; | market18@leapchem.com | China | 24727 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38838 | 58 |
View Lastest Price from Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)- manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
![]() |
2025-07-24 | Ezatiostat
168682-53-9
|
US $54.00-179.00 / mg | 97.95% | 10g | TargetMol Chemicals Inc. | ||
![]() |
2020-02-14 | Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)-
168682-53-9
|
US $7.00 / KG | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- Ezatiostat
168682-53-9
- US $54.00-179.00 / mg
- 97.95%
- TargetMol Chemicals Inc.
-
- Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)-
168682-53-9
- US $7.00 / KG
- 99%
- Career Henan Chemical Co