(1R,2R)-ethyl2-(3,4-difluorophenyl)cyclopropane carboxylate
- CAS No.
- 1006376-61-9
- Chemical Name:
- (1R,2R)-ethyl2-(3,4-difluorophenyl)cyclopropane carboxylate
- Synonyms
- Ticagrelor Impurity 120;Ticagrelor-21;Ticagrelor Impurity 135;(1R,2R)-ethyl2-(3,4-difluorophenyl)cyclopropane carboxylate;Ethyl (1R,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxylate;ethyl(1R,2R)-2-(3,4-difluorophenyl)cyclopropane-1-carboxylate;(1R,2R)-trans-Ethyl 2-(3,4-difluorophenyl)cyclopropanecarboxylate;(1R,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxylic acid ethyl ester;(1R,2R)-2-(3,4-Difluorophenyl)cyclopropan-1-carboxylic acid ethyl ester;Cyclopropanecarboxylic acid, 2-(3,4-difluorophenyl)-, ethyl ester,(1R,2R)-
- CBNumber:
- CB72563452
- Molecular Formula:
- C12H12F2O2
- Molecular Weight:
- 226.22
- MDL Number:
- MFCD22419930
- MOL File:
- 1006376-61-9.mol
| Product description | Number | Pack Size | Price |
| (1R,2R)-trans-Ethyl2-(3,4-difluorophenyl)cyclopropanecarboxylate | E916678 | 25mg | $220 |
| (1R,2R)-trans-Ethyl2-(3,4-difluorophenyl)cyclopropanecarboxylate | E916678 | 5mg | $55 |
| (1R,2R)-trans-Ethyl2-(3,4-difluorophenyl)cyclopropanecarboxylate | E916678 | 10mg | $100 |
| Cyclopropanecarboxylicacid,2-(3,4-difluorophenyl)-,ethylester,(1R,2R)- | CS-B0684 | 100mg | $166 |
| (1R,2R)-Ethyl2-(3,4-difluorophenyl)cyclopropanecarboxylate | 2836AH | 100mg | $235 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
(1R,2R)-ethyl2-(3,4-difluorophenyl)cyclopropane carboxylate price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | E916678 | (1R,2R)-trans-Ethyl2-(3,4-difluorophenyl)cyclopropanecarboxylate | 1006376-61-9 | 25mg | $220 | 2021-12-16 | Buy |
| TRC | E916678 | (1R,2R)-trans-Ethyl2-(3,4-difluorophenyl)cyclopropanecarboxylate | 1006376-61-9 | 5mg | $55 | 2021-12-16 | Buy |
| TRC | E916678 | (1R,2R)-trans-Ethyl2-(3,4-difluorophenyl)cyclopropanecarboxylate | 1006376-61-9 | 10mg | $100 | 2021-12-16 | Buy |
| ChemScene | CS-B0684 | Cyclopropanecarboxylicacid,2-(3,4-difluorophenyl)-,ethylester,(1R,2R)- | 1006376-61-9 | 100mg | $166 | 2021-12-16 | Buy |
| AK Scientific | 2836AH | (1R,2R)-Ethyl2-(3,4-difluorophenyl)cyclopropanecarboxylate | 1006376-61-9 | 100mg | $235 | 2021-12-16 | Buy |
(1R,2R)-ethyl2-(3,4-difluorophenyl)cyclopropane carboxylate Chemical Properties,Uses,Production
Uses
(1R,2R)-trans-Ethyl 2-(3,4-difluorophenyl)cyclopropanecarboxylate is a useful chemical in studying the inhibitory effect on ADP-induced platelet aggregation of ticagrelor derivatives as antiplatelet agents.
Synthesis
867-13-0
1006376-63-1
1006376-61-9
The general procedure for the synthesis of ethyl (1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylate from triethyl phosphonoacetate and (S)-2-(3,4-difluorophenyl)oxirane was as follows: sodium tert-butoxide (115.2 g, 1.2 mol) and triethyl phosphonoacetate (269.0 g, 1.2 mol) with toluene (150 g) were added to a 2 L three-necked flask and heated to 100 °C. Subsequently, a toluene solution of (S)-2-(3,4-difluorophenyl)oxirane was slowly added dropwise, and the reaction temperature was controlled to be maintained at 100 °C, and the reaction lasted for 4 hours. After completion of the reaction, the reaction mixture was cooled and quenched by addition of water (500 g). The organic phase was separated, dried with anhydrous sodium sulfate and concentrated to afford the target product ethyl (1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylate 203.9 g in 90.6% yield, 99.2% ee value and 99.2% purity.
References
[1] Patent: CN107686447, 2018, A. Location in patent: Paragraph 0024; 0029; 0030; 0034
[2] Patent: WO2008/18823, 2008, A1. Location in patent: Page/Page column 30
[3] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 11, p. 3598 - 3602
(1R,2R)-ethyl2-(3,4-difluorophenyl)cyclopropane carboxylate Preparation Products And Raw materials
(1R,2R)-ethyl2-(3,4-difluorophenyl)cyclopropane carboxylate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
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