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(S)-MEPHENYTOIN

(S)-MEPHENYTOIN structure

CAS No.: 70989-04-7

Chemical Name:: (S)-MEPHENYTOIN

Synonyms: Mephenitoin S;(S)-MEPHENYTOIN;(S)-Mephenitoin;(S)-Mephenytoine;(S)-(+)-MEPHENYTOIN;Mephenytoin Impurity 2;(S)-Mephenytoin - Bio-X ?;(S)-Mephenytoin, 10 mM in DMSO;(S)-5-ETHYL-3-METHYL-5-PHENYLHYDANTOIN;(5S)-5-Ethyl-3-methyl-5-phenylhydantoin

CBNumber:: CB7257425

Molecular Formula:: C12H14N2O2

Molecular Weight:: 218.25

MDL Number:: MFCD00270025

MOL File:: 70989-04-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 04:43:56

Product description	Number	Pack Size	Price
(S)-(+)-Mephenytoin solid, ≥98% (HPLC)	UC175	5mg	$990
(S)-(+)-Mephenytoin solid, ≥98% (HPLC)	UC175	10mg	$1730
(S)-Mephenytoin ≥98%	11913	1mg	$47
(S)-Mephenytoin ≥98%	11913	5mg	$116
(S)-Mephenytoin ≥98%	11913	10mg	$208
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(S)-MEPHENYTOIN Properties

Melting point	135-138 °C
Density	1.154±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: soluble
pka	8.07±0.70(Predicted)
form	solid
color	off-white
InChI	1S/C12H14N2O2/c1-3-12(9-7-5-4-6-8-9)10(15)14(2)11(16)13-12/h4-8H,3H2,1-2H3,(H,13,16)/t12-/m0/s1
InChIKey	GMHKMTDVRCWUDX-LBPRGKRZSA-N
SMILES	CC[C@]1(NC(=O)N(C)C1=O)c2ccccc2
FDA UNII	D9818430MW
UNSPSC Code	12161501
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P264-P270-P301+P312-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

22-36/37/38

Safety Statements

26-36

WGK Germany

HS Code

29332100

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	0
2		0

(S)-MEPHENYTOIN price More Price(81)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	UC175	(S)-(+)-Mephenytoin solid, ≥98% (HPLC)	70989-04-7	5mg	$990	2026-04-30	Buy
Sigma-Aldrich	UC175	(S)-(+)-Mephenytoin solid, ≥98% (HPLC)	70989-04-7	10mg	$1730	2026-04-30	Buy
Cayman Chemical	11913	(S)-Mephenytoin ≥98%	70989-04-7	1mg	$47	2026-04-30	Buy
Cayman Chemical	11913	(S)-Mephenytoin ≥98%	70989-04-7	5mg	$116	2026-04-30	Buy
Cayman Chemical	11913	(S)-Mephenytoin ≥98%	70989-04-7	10mg	$208	2026-04-30	Buy

Product number	Packaging	Price	Buy
UC175	5mg	$990	Buy
UC175	10mg	$1730	Buy
11913	1mg	$47	Buy
11913	5mg	$116	Buy
11913	10mg	$208	Buy

(S)-MEPHENYTOIN Chemical Properties,Uses,Production

Chemical Properties

White Crystalline Solid

Uses

S-Mephenytoin has been used as a CYP2C19 substrate for the analysis of cytochrome P450 metabolism. S-Mephenytoin has also been used as probe substrates for LC/MS-based analysis of relative activity factor (RAF).

Uses

(S)-Mephenytoin can be used as an anticonvulsant agent.

Definition

ChEBI: (S)-Mephenytoin is an imidazolidine-2,4-dione.

Biological Activity

(s)-mephenytoin is an anticonvulsive drug which is metabolized by n-demethylation and 4-hydroxylation (of the aromatic ring). (s)-mephenytoin is a substrate of the cytochrome p450 (cyp) isoform cyp2c19, also known as mephenytoin 4-hydroxylase [1].cyp2c19 is the main mephenytoin 4-hydroxylase in humans implicated in metabolizing a variety of therapeutic agents, such as omeprazole, proguanil, diazepam, propranolol, citalopram, imipramine, and certain barbiturates [2].

Biochem/physiol Actions

CYP2B6 & CYP2C19 substrate. Methenytoin isomer. Anticonvulsant; antiepileptic.

in vitro

in the presence of cytochrome b5, the km value for s-mephenytoin was 1.25 mm with all five purified cytochrome p-450s preparations, and vmax values were 0.8-1.25 nmol of 4-hydroxy product formed per min/nmol of p-450 [1].

References

[1] shimada t, misono k s, guengerich f p. human liver microsomal cytochrome p-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. purification and characterization of two similar forms involved in the reaction[j]. journal of biological chemistry, 1986, 261(2): 909-921.
[2] ferguson r j, de morais s m f, benhamou s, et al. a new genetic defect in human cyp2c19: mutation of the initiation codon is responsible for poor metabolism of s-mephenytoin[j]. journal of pharmacology and experimental therapeutics, 1998, 284(1): 356-361.

(S)-MEPHENYTOIN Preparation Products And Raw materials

Raw materials

Preparation Products

(S)-MEPHENYTOIN Suppliers

Global( 125)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19853	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3135	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39039	58
GIHI CHEMICALS CO.,LIMITED	+86-571-86217390; +8618058761490	info@gihichemicals.com	China	49969	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+86-18621343501; +undefined18621343501	product@acmec-e.com	China	33324	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	+8613817748580	cooperation@kean-chem.com	China	40066	58

Supplier	Advantage
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
BOC Sciences	58
Nantong HI-FUTURE Biology Co., Ltd.	58
TargetMol Chemicals Inc.	58
GIHI CHEMICALS CO.,LIMITED	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Aladdin Scientific	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	58

View Lastest Price from (S)-MEPHENYTOIN manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-04-22	(S)-Mephenytoin 70989-04-7	$51.00-172.00		99.82%	10g	TargetMol Chemicals Inc.

(S)-Mephenytoin
70989-04-7
$51.00-172.00
99.82%
TargetMol Chemicals Inc.

(S)-MEPHENYTOIN Spectrum

(S)-MEPHENYTOIN(70989-04-7)¹HNMR

70989-04-7((S)-MEPHENYTOIN)Related Search:

(R)-MEPHENYTOIN,(R)-(-)-MEPHENYTOIN 4-HYDROXY MEPHENYTOIN 4-HYDROXY MEPHENYTOIN-D3 (S)-MEPHENYTOIN 2-PHENYLBUTYRYLUREA

7,8-DIHYDROXY-6-METHOXYCOUMARIN 5-Phenylhydantoin (S)-(+)-2-Phenylglycine amide Mephenytoin S-(+)-N-Desmethyl Mephenytoin

(S)-(+)-N-3-Benzylnirvanol rac N-Desmethyl Mephenytoin-deuterated,rac N-Desmethyl Mephenytoin-D5 (Major) RAC MEPHENYTOIN-D3 1,2-Ethanediamine,N2,N2-dimethyl-1-phenyl-,(1S)-(9CI) DESMETHYL MEPHENYTOIN,rac N-Desmethyl Mephenytoin

N-DESMETHYL MEPHENYTOIN-D5 rac Mephenytoin-D5 MEPHENYTOIN USP(CRM STANDARD)

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(S)-(+)-5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione, (S)-(+)-5-Ethyl-3-methyl-5-phenylhydantoin (5S)-5-Ethyl-3-methyl-5-phenylhydantoin (5S)-5β-Ethyl-3-methyl-5-phenylhydantoin Mephenitoin S (5S)-5-ethyl-3-methyl-5-phenyl-imidazolidine-2,4-dione (5S)-5-ethyl-3-methyl-5-phenylimidazolidine-2,4-dione (S)-(+)-MEPHENYTOIN (S)-(+)-5-ETHYL-3-METHYL-5-PHENYL-2,4-IMIDAZOLIDINEDIONE (S)-(+)-5-ETHYL-3-METHYL-5-PHENYLHYDANTOIN (S)-5-ETHYL-3-METHYL-5-PHENYLHYDANTOIN (5S)-5-Ethyl-3-Methyl-5-phenyl-2,4-iMidazolidinedione 2,4-IMidazolidinedione, 5-ethyl-3-Methyl-5-phenyl-, (5S)- (S)-5-ethyl-3-Methyl-5-phenyliMidazolidine-2,4-dione (S)-Mephenytoine (S)-MEPHENYTOIN Mephenytoin Impurity 2 (S)-Mephenitoin inhibit,(+)-Mephenytoin,cytochrome,Inhibitor,(S)Mephenytoin,CYP2C19,(S) Mephenytoin,P450,(S)-Mephenytoin,anticonvulsive (S)-(+)-Mephenytoin solid, >=98% (HPLC) (S)-Mephenytoin, 10 mM in DMSO (S)-Mephenytoin - Bio-X ? 70989-04-7 Hydantoins and Derivatives Hydantoins & Derivatives Intermediates & Fine Chemicals Pharmaceuticals Heterocycles