(5-Fluoro-pyridin-2-yl)-Methyl-aMine
- CAS No.
- 868636-72-0
- Chemical Name:
- (5-Fluoro-pyridin-2-yl)-Methyl-aMine
- Synonyms
- 5-fluoro-N-methyl-2-Pyridinamine;3-Fluoro-6-(methylamino)pyridine;5-fluoro-N-Methylpyridin-2-aMine;2-Pyridinamine, 5-fluoro-N-methyl-;(5-Fluoro-pyridin-2-yl)-Methyl-aMine
- CBNumber:
- CB72575303
- Molecular Formula:
- C6H7FN2
- Molecular Weight:
- 126.13
- MDL Number:
- MFCD11848519
- MOL File:
- 868636-72-0.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H314 |
| Precautionary statements | P260-P264-P280-P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P321-P305+P351+P338-P405-P501 |
| HS Code | 2933399990 |
(5-Fluoro-pyridin-2-yl)-Methyl-aMine price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | TJB63672 | 3-Fluoro-6-(methylamino)pyridine | 868636-72-0 | 2.5g | $354 | 2026-06-05 | Buy |
| Apolloscientific | PC408017 | 3-Fluoro-6-(methylamino)pyridine 95% | 868636-72-0 | 100mg | $29 | 2026-06-04 | Buy |
| Apolloscientific | PC408017 | 3-Fluoro-6-(methylamino)pyridine 95% | 868636-72-0 | 250mg | $39 | 2026-06-04 | Buy |
| Apolloscientific | PC408017 | 3-Fluoro-6-(methylamino)pyridine 95% | 868636-72-0 | 1g | $74 | 2026-06-04 | Buy |
| Apolloscientific | PC408017 | 3-Fluoro-6-(methylamino)pyridine 95% | 868636-72-0 | 5g | $278 | 2026-06-04 | Buy |
(5-Fluoro-pyridin-2-yl)-Methyl-aMine Chemical Properties, Uses, Production
Synthesis
74-88-4
868636-72-0
Step 1. Synthesis of 5-fluoro-N-methylpyridin-2-amine: A suspension of sodium hydride (60% dispersed in mineral oil, 117.8 mg, 4.91 mmol) was made in dry tetrahydrofuran (25 mL). Subsequently, a solution of 5-fluoropyridin-2-amine (500 mg, 4.46 mmol) in tetrahydrofuran (25 mL) was added dropwise to this suspension. The reaction mixture was stirred at room temperature and maintained at 40 °C for 30 min. After that, the reaction system was cooled to -40 °C and methyl iodide (696.9 mg, 4.91 mmol) was slowly added. After addition, the reaction mixture was returned to room temperature and stirred overnight. Upon completion of the reaction, the reaction was quenched by the addition of water and the mixture was extracted with ethyl acetate. The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting crude product was purified by fast column chromatography on silica gel with hexane/ethyl acetate (4:1, v/v) as eluent to give 129 mg of the title compound in 23% yield. The product was characterized by 1H-NMR (CDCl3): δ 7.97 (1H, d, J = 2.6 Hz), 7.28-7.17 (1H, m), 6.34 (1H, dd, J = 3.5, 9.1 Hz), 2.90 (3H, d, J = 5.1 Hz).
References
[1] Patent: WO2005/105732, 2005, A1. Location in patent: Page/Page column 57-58
(5-Fluoro-pyridin-2-yl)-Methyl-aMine Preparation Products And Raw materials
Raw materials
Preparation Products
(5-Fluoro-pyridin-2-yl)-Methyl-aMine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Amber MolTech LLC | 086-010-62176588 | amber@jyamber.com | China | 10150 | 56 |
| SuZhou ShiYa Biopharmaceuticals, Inc. | 86(512)5235 8471 17715136450 | sales@shiyabiopharm.com | China | 4167 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| 9ding chemical ( Shanghai) Limited | 021-021-52271985 17721149837 | sales@9dingchem.com | China | 19780 | 60 |
| Aikon International Limited | 025-66061636 19370895928 | qqyang@aikonchem.com | China | 15810 | 58 |
| Suzhou Nuoouman Biological Technology Co., Ltd. | 15026866316 | 180642609@qq.com | China | 4966 | 58 |
| Yujinpharma(Tianjin) Technology Co.,Ltd. | 13370351217 kungfu1217@1 | kungfu1217@163.com | China | 7991 | 58 |
| Hebei Beckman Biotechnology Co., Ltd. | 15961617865 15961617865; | 2245485247@qq.com | China | 4964 | 58 |
| Wuhan chuang he chemical co. LTD | 15907120073 | 1261789306@qq.com | China | 1358 | 58 |
