IRAK-4 Polyclonal Antibody

Description

The toll-like receptor (TLR) family in mammals comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an interleukin-1 (IL-1) receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules.1 Interleukin-1 receptor-associated kinases (IRAKs) are important mediators in the signal transduction of Toll/IL-1 receptor (TIR) family members.2 The cytoplasmic domains of TIR proteins interact with the adapter protein, MyD88. MyD88 then recruits IRAKs (IRAK1-4), which in turn interact with other adapter molecules, such as TRAF6 to activate NF-κB and MAPK pathways. A member of this family, IRAK-4 has been identified.3 IRAK4 may act as an upstream activator of IRAK1. IRAK4 is important for LPS activation of TLRs. Mice lacking IRAK4 are resistant to lethal doses of LPS and are also severely impaired in their responses to viral and bacterial challenges.4,5WARNING This product is not for human or veterinary use.