di-tert-butyl 9H-purin-6-yliMidodicarbonate
- CAS No.
- 309947-86-2
- Chemical Name:
- di-tert-butyl 9H-purin-6-yliMidodicarbonate
- Synonyms
- N6,N6-diBocadenine;6,6-di-Boc-adenine;6-[Bis(Boc)amino]purine;N6,N6-bis(tert-butoxycarbonyl)adenine;6,6-di-Boc-adenine/6-[Bis(Boc)amino]purine;di-tert-butyl 9H-purin-6-yliMidodicarbonate;tert-Butyl N-tert-butoxycarbonyl-N-(7H-purin-6-yl)carbamate;1,3-Bis(1,1-dimethylethyl) 2-(9H-purin-6-yl)imidodicarbonate;tert-butyl N-[(tert-butoxy)carbonyl]-N-(9H-purin-6-yl)carbamate;tert-butyl N-[(2-methylpropan-2-yl)oxycarbonyl]-N-(7H-purin-6-yl)carbamate
- CBNumber:
- CB72610288
- Molecular Formula:
- C15H21N5O4
- Molecular Weight:
- 335.36
- MDL Number:
- MFCD17676144
- MOL File:
- 309947-86-2.mol
- MSDS File:
- SDS
di-tert-butyl 9H-purin-6-yliMidodicarbonate price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 096748 | tert-Butyl N-tert-butoxycarbonyl-N-(7H-purin-6-yl)carbamate | 309947-86-2 | 250.00mg | $591 | 2026-05-18 | Buy |
| Matrix Scientific | 096748 | tert-Butyl N-tert-butoxycarbonyl-N-(7H-purin-6-yl)carbamate | 309947-86-2 | 1.00g | $1311 | 2026-05-18 | Buy |
| Synthonix | B22960 | tert-butyl N-[(tert-butoxy)carbonyl]-N-(9H-purin-6-yl)carbamate 97% | 309947-86-2 | 1g | $26 | 2026-05-06 | Buy |
| Synthonix | B22960 | tert-butyl N-[(tert-butoxy)carbonyl]-N-(9H-purin-6-yl)carbamate 97% | 309947-86-2 | 5g | $70 | 2026-05-06 | Buy |
| Synthonix | B22960 | tert-butyl N-[(tert-butoxy)carbonyl]-N-(9H-purin-6-yl)carbamate 97% | 309947-86-2 | 10g | $140 | 2026-05-06 | Buy |
di-tert-butyl 9H-purin-6-yliMidodicarbonate Chemical Properties, Uses, Production
Synthesis
24424-99-5
66224-66-6
309947-86-2
Adenine (1.35 g, 10 mmol) and 4-dimethylaminopyridine (DMAP, 122 mg, 1 mmol) were dissolved in tetrahydrofuran (THF, 50 mL) under argon protection. Subsequently, di-tert-butyl dicarbonate (Boc2O, 9.38 g, 43 mmol) was added to this solution. The reaction mixture was stirred at room temperature for 5 hours. After completion of the reaction, the solvent was removed under reduced pressure and ethyl acetate (EtOAc, 400 mL) was added to dissolve the residue. The resulting solution was washed sequentially with 1N hydrochloric acid (HCl, 30 mL) and saturated sodium chloride solution (NaCl, 3 x 100 mL). The organic phase was dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. The residue was dissolved in a solvent mixture of methanol (100 mL) and saturated sodium bicarbonate solution (NaHCO3, 45 mL), followed by stirring for 1.5 hours at 50 °C. After completion of the reaction, the solvent was removed under reduced pressure and diluted by adding water (100 mL). The aqueous phase was extracted with chloroform (CHCl3, 2 x 300 mL), the organic phases were combined and dried over anhydrous sodium sulfate (Na2SO4). After removal of the solvent under reduced pressure, the crude product was purified by fast column chromatography (eluent: cyclohexane/ethyl acetate, 10:90) to afford 6-[bis(Boc)amino]purine (2.44 g, 73%) as a white solid.1H NMR (DMSO-d6) δ: 13.69 (s, 1H, NH), 8.80 (s, 1H, H-2), 8.63 (s, 1H H-8), 1.36 (s, 18H, C(CH3)3) ppm.
References
[1] Steroids, 2012, vol. 77, # 12, p. 1177 - 1191,15
[2] Steroids, 2012, vol. 77, # 12, p. 1177 - 1191
di-tert-butyl 9H-purin-6-yliMidodicarbonate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai PharmaPartner Co., Ltd. | 19983777532 | pharmabridge@163.com | China | 500 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Changzhou Qinuo Chemical Co., Ltd.Co., Ltd. | 0519-0519-83812535 | sales@qinuochem.com | China | 287 | 60 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Suzhou Crst Pharmatech Co., Ltd. | 0512-62910395 17751098781 | sales@crstpharma.com | China | 497 | 58 |
| Shanghai GL Peptide Ltd. | +86-21-61263310 13764994101 | fisherwang@glschina.com | China | 8059 | 55 |
| Chongqing AoShe Biological Chemical Co., Ltd. | 023-63225655 13320248848 | 2366581735@qq.com | China | 501 | 55 |
| Zhengzhou AiXi Technology Co., Ltd. | 0371-56787280 13137706083 | m18539565376@163.com | China | 999 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Chengdu Xiaojia Technology Co., Ltd. | 15902830537 | zhanghao@happysyn.com | China | 2360 | 55 |
View Latest Price from di-tert-butyl 9H-purin-6-yliMidodicarbonate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2020-01-13 | di-tert-butyl 9H-purin-6-yliMidodicarbonate
309947-86-2
|
$1.00 | 1g | 99.0% | 100 kg | Career Henan Chemical Co |
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- di-tert-butyl 9H-purin-6-yliMidodicarbonate
309947-86-2
- $1.00
- 99.0%
- Career Henan Chemical Co
