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4(1H)-PyriMidinone, 5-(4-broMophenyl)-6-hydroxy-

4(1H)-PyriMidinone, 5-(4-broMophenyl)-6-hydroxy- structure

CAS No.: 706811-25-8

Chemical Name:: 4(1H)-PyriMidinone, 5-(4-broMophenyl)-6-hydroxy-

Synonyms: Macitentan Impurity 25;Macitentan Impurity 25 CRS;5-(4-broMophenyl)pyriMidine-4,6-diol;5-(4-Bromophenyl)-4,6-pyrimidinediol;5-(4-Bromophenyl)-4,6-dihydroxpyrimidine;5-(4-broMophenyl)pyriMidine-4,6(1H,5H)-dione;5-(4-bromophenyl)-6-hydroxypyrimidin-4(3H)-one;5-(4-bromophenyl)-4-hydroxy-1H-pyrimidin-6-one;5-(4-Bromophenyl)-6-hydroxypyrimidin-4(1H)-one;5-(4-broMophenyl)-6-hydroxy- 4(1H)-PyriMidinone

CBNumber:: CB72623954

Molecular Formula:: C10H7BrN2O2

Molecular Weight:: 267.08

MDL Number:: MFCD28044068

MOL File:: 706811-25-8.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:51

Request For Quotation

4(1H)-PyriMidinone, 5-(4-broMophenyl)-6-hydroxy- Properties

Density	1.74±0.1 g/cm3(Predicted)
storage temp.	2-8°C
pka	4.69±0.10(Predicted)
Appearance	White to yellow Solid
InChI	InChI=1S/C10H7BrN2O2/c11-7-3-1-6(2-4-7)8-9(14)12-5-13-10(8)15/h1-5H,(H2,12,13,14,15)
InChIKey	PIUMVXYVNAISNG-UHFFFAOYSA-N
SMILES	C1NC(O)=C(C2=CC=C(Br)C=C2)C(=O)N=1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P280-P305+P351+P338
HS Code	2933599590

4(1H)-PyriMidinone, 5-(4-broMophenyl)-6-hydroxy- price More Price(23)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
AK Scientific	0056AP	4(1H)-Pyrimidinone,5-(4-bromophenyl)-6-hydroxy	706811-25-8	1g	$80	2021-12-16	Buy
Apolloscientific	OR55029	5-(4-Bromophenyl)pyrimidine-4,6-diol	706811-25-8	1g	$182	2021-12-16	Buy
SynQuest Laboratories	4H56-9-9D	5-(4-Bromophenyl)pyrimidine-4,6-diol	706811-25-8	1g	$200	2021-12-16	Buy
Apolloscientific	OR55029	5-(4-Bromophenyl)pyrimidine-4,6-diol	706811-25-8	5g	$508	2021-12-16	Buy
SynQuest Laboratories	4H56-9-9D	5-(4-Bromophenyl)pyrimidine-4,6-diol	706811-25-8	5G	$560	2021-12-16	Buy

Product number	Packaging	Price	Buy
0056AP	1g	$80	Buy
OR55029	1g	$182	Buy
4H56-9-9D	1g	$200	Buy
OR55029	5g	$508	Buy
4H56-9-9D	5G	$560	Buy

4(1H)-PyriMidinone, 5-(4-broMophenyl)-6-hydroxy- Chemical Properties,Uses,Production

Uses

5-(4-Bromophenyl)pyrimidine-4,6-diol is used in preparation of pharmaceutical intermediate of Macitentan.

Synthesis

77287-34-4

2-(4-BROMOPHENYL)-PROPANEDIOIC ACID, 1,3-MDIETHYL ESTER

149506-35-4

4(1H)-PyriMidinone, 5-(4-broMophenyl)-6-hydroxy-

706811-25-8

To a stirred solution of 100 g of dimethyl 2-(4-bromophenyl)malonate (0.348 mol) dissolved in 400 cm3 methanol at 20-25 °C, 30 g of formamide (0.66 mol) and 30 g of sodium methanolate (0.555 mol) were added sequentially. The reaction mixture was heated to 70 °C and maintained at this temperature until the reaction was complete (monitored by HPLC). After completion of the reaction, methanol was removed by distillation under reduced pressure at 70°C to give a syrupy substance. The syrup was cooled to 25-30 °C and diluted with 2 dm3 water. The pH of the solution was adjusted to 2-2.5 with concentrated hydrochloric acid and this pH was maintained for 45 min. The precipitated solid was collected by filtration and washed with water until the filtrate reached pH 7-7.5. The product was blotted dry and dried under reduced pressure at 100°C to give the crude product 5-(4-bromophenyl)-6-hydroxypyrimidin-4(1H)-one. The crude product was dissolved in 500 cm3 methanol and heated to 60-65°C and kept for 1 hour. The reaction mixture was then cooled to 25-30°C and left to stand for 30 minutes. The resulting solid was filtered, washed with methanol and dried under reduced pressure at 50-55°C to give the pure product 5-(4-bromophenyl)-6-hydroxypyrimidin-4(1H)-one. Yield: 70 g (75.25%); HPLC purity: 99.5%; melting point: 176-180 °C. The spectral data of the obtained compounds were in agreement with literature reports [8].

References

[1] Monatshefte fur Chemie, 2018, vol. 149, # 3, p. 653 - 661

4(1H)-PyriMidinone, 5-(4-broMophenyl)-6-hydroxy- Preparation Products And Raw materials

Raw materials

formamide Formamidine acetate 2-(4-BROMOPHENYL)-PROPANEDIOIC ACID, 1,3-MDIETHYL ESTER Sodium Methoxide Methanol

Preparation Products

4(1H)-PyriMidinone, 5-(4-broMophenyl)-6-hydroxy- Suppliers

Global( 127)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Suzhou Biosyntech Co., Ltd	+86-13921151340	sales2@biosyntech-suzhou.com	China	104	58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	+86-13017695106 +86-13676922317	jiuyitime@fdachem.com	China	9029	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29852	58
Zhejiang ZETian Fine Chemicals Co. LTD	+8618957127338	stella@zetchem.com	China	2161	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10035	58
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	12151	58

Supplier	Advantage
Suzhou Biosyntech Co., Ltd	58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58
Jinan Carbotang Biotech Co.,Ltd.	58
Standardpharm Co. Ltd.	58
Fuxin Pharmaceutical	58
Zhengzhou Alfa Chemical Co.,Ltd	58

View Lastest Price from 4(1H)-PyriMidinone, 5-(4-broMophenyl)-6-hydroxy- manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-07-24	5-(4-Bromophenyl)-6-hydroxy-4(1H)-pyrimidinone 706811-25-8	US $2.00-5.00 / kg	1kg	99%	100kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2023-07-19	5-(4-Bromophenyl)pyrimidine-4,6-diol 706811-25-8	US $30.00 / KG	1KG	99%	20 Tons	Wuhan wingroup Pharmaceutical Co., Ltd
2019-07-07	4(1H)-PyriMidinone, 5-(4-broMophenyl)-6-hydroxy- 706811-25-8	US $0.00 / KG	1KG	90%-99.9%	500kg	Career Henan Chemical Co

5-(4-Bromophenyl)-6-hydroxy-4(1H)-pyrimidinone
706811-25-8
US $2.00-5.00 / kg
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

5-(4-Bromophenyl)pyrimidine-4,6-diol
706811-25-8
US $30.00 / KG
99%
Wuhan wingroup Pharmaceutical Co., Ltd

4(1H)-PyriMidinone, 5-(4-broMophenyl)-6-hydroxy-
706811-25-8
US $0.00 / KG
90%-99.9%
Career Henan Chemical Co

4(1H)-PyriMidinone, 5-(4-broMophenyl)-6-hydroxy- Spectrum

4(1H)-PyriMidinone, 5-(4-broMophenyl)-6-hydroxy-(706811-25-8)¹HNMR

706811-25-8(4(1H)-PyriMidinone, 5-(4-broMophenyl)-6-hydroxy-)Related Search:

Macitidine related impurities PropylsulfaMide CarbaMic acid, N-[(propylaMino)sulfonyl]-, phenylMethyl ester N-Propylsulfuric diamide-sodium SulfaMide, N-propyl-,(potassiuM salt)(1:1)

Macitentan impurity A 5-Bromo-2-chloropyrimidine 5-(4-Bromophenyl)-4,6-dichloropyrimidine 2-(4-BROMOPHENYL)-PROPANEDIOIC ACID, 1,3-MDIETHYL ESTER Macitentan impurity B

macitentan ACT 080803 Macitentan IMpurity Masitatin impurity 1 NA

Macitidine impurity 2 Masitatin impurity 3 Macitidine impurity 5

1of4

4(1H)-PyriMidinone, 5-(4-broMophenyl)-6-hydroxy- 5-(4-broMophenyl)pyriMidine-4,6(1H,5H)-dione 5-(4-broMophenyl)-6-hydroxy- 4(1H)-PyriMidinone 5-(4-broMophenyl)pyriMidine-4,6-diol 5-(4-Bromophenyl)-6-hydroxypyrimidin-4(1H)-one Macitentan Impurity 25 5-(4-Bromophenyl)-4,6-pyrimidinediol 5-(4-bromophenyl)-4-hydroxy-1H-pyrimidin-6-one 5-(4-bromophenyl)-6-hydroxypyrimidin-4(3H)-one Macitentan Impurity 25 CRS 5-(4-Bromophenyl)-4,6-dihydroxpyrimidine (1H)-PyriMidinone, 5-(4-broMophenyl)-6-hydroxy- 706811-25-8