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ChemicalBook >> CAS DataBase List >>PyriMido[5',4':5,6]pyriMido[1,2-a]benziMidazol-5(6H)-one, 6-(2,6-diMethylphenyl)-2-[[4-(4-Methyl-1-piperazinyl)phenyl]aMino]-

PyriMido[5',4':5,6]pyriMido[1,2-a]benziMidazol-5(6H)-one, 6-(2,6-diMethylphenyl)-2-[[4-(4-Methyl-1-piperazinyl)phenyl]aMino]-

PyriMido[5',4':5,6]pyriMido[1,2-a]benziMidazol-5(6H)-one, 6-(2,6-diMethylphenyl)-2-[[4-(4-Methyl-1-piperazinyl)phenyl]aMino]- Structure
PyriMido[5',4':5,6]pyriMido[1,2-a]benziMidazol-5(6H)-one, 6-(2,6-diMethylphenyl)-2-[[4-(4-Methyl-1-piperazinyl)phenyl]aMino]- structure
CAS No.
847950-09-8
Chemical Name:
PyriMido[5',4':5,6]pyriMido[1,2-a]benziMidazol-5(6H)-one, 6-(2,6-diMethylphenyl)-2-[[4-(4-Methyl-1-piperazinyl)phenyl]aMino]-
Synonyms
Lck Inhibitor;Lck Inhibitor 25;TC-S 7003 (Lck Inhibitor);6-(2,6-Dimethylphenyl)-2-[[4-(4-methyl-1-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-one;6-(2,6-Dimethylphenyl)-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-one;PyriMido[5',4':5,6]pyriMido[1,2-a]benziMidazol-5(6H)-one, 6-(2,6-diMethylphenyl)-2-[[4-(4-Methyl-1-piperazinyl)phenyl]aMino]-
CBNumber:
CB72628328
Molecular Formula:
C31H30N8O
Molecular Weight:
530.62
MDL Number:
MFCD18782603
MOL File:
847950-09-8.mol
Last updated:2025-04-17 18:22:24
Request For Quotation

PyriMido[5',4':5,6]pyriMido[1,2-a]benziMidazol-5(6H)-one, 6-(2,6-diMethylphenyl)-2-[[4-(4-Methyl-1-piperazinyl)phenyl]aMino]- Properties

Boiling point 809.1±75.0 °C(Predicted)
Density 1.36±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
form crystalline solid
pka 7.87±0.42(Predicted)
color Light yellow to yellow

PyriMido[5',4':5,6]pyriMido[1,2-a]benziMidazol-5(6H)-one, 6-(2,6-diMethylphenyl)-2-[[4-(4-Methyl-1-piperazinyl)phenyl]aMino]- price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC T127030 TC-S7003 847950-09-8 10mg $235 2021-12-16 Buy
ApexBio Technology A3539 Lck Inhibitor 847950-09-8 10mg $292 2021-12-16 Buy
American Custom Chemicals Corporation CHM0292993 6-(2,6-DIMETHYLPHENYL)-2-[[4-(4-METHYL-1-PIPERAZINYL)PHENYL]AMINO]-PYRIMIDO-[5',4',5,6]PYRIMIDO-[1,2-A]BENZIMIDAZOL-5(6H)-ONE 95.00% 847950-09-8 5MG $505.4 2021-12-16 Buy
ChemScene CS-1448 Lck Inhibitor 98.98% 847950-09-8 5mg $142 2021-12-16 Buy
ApexBio Technology A3539 Lck Inhibitor 847950-09-8 5mg $183 2021-12-16 Buy
Product number Packaging Price Buy
T127030 10mg $235 Buy
A3539 10mg $292 Buy
CHM0292993 5MG $505.4 Buy
CS-1448 5mg $142 Buy
A3539 5mg $183 Buy

PyriMido[5',4':5,6]pyriMido[1,2-a]benziMidazol-5(6H)-one, 6-(2,6-diMethylphenyl)-2-[[4-(4-Methyl-1-piperazinyl)phenyl]aMino]- Chemical Properties,Uses,Production

Uses

TC-S 7003 is a novel, potent and orally active inhibitor of Lymphocyte Specific Kinase (Lck).

in vivo

Lck 抑制剂 (0-60 mg/kg；口服每天一次；从第 9 天到第 17 天) 显示出对关节炎的剂量依赖性抑制[1]。
Lck 抑制剂 (口服5 mg/kg) 处理显示Cmax、AUC0-∞、tmax和F%分别为82 ng/mL、862 ng h/mL，和 17%，分别[1]。

Animal Model:Male Lewis rat (adjuvant-inducedarthritis model) [1]
Dosage:0, 30, and 60 mg/kg
Administration:P.o.; once daily; from day 9 today 17
Result:Showed a dose-dependent inhibition of arthritis, with an ED50 estimated at 24 mg/kg.
Animal Model:Sprague-Dawley Rats[1]
Dosage:P.o. (Pharmacokinetic Analysis)
Administration:5 mg/kg
Result:The Cmax, AUC0-∞, tmax and F% were 82 ng/mL, 862 ng h/mL, and 17%, respectively.

storage

Store at -20°C

PyriMido[5',4':5,6]pyriMido[1,2-a]benziMidazol-5(6H)-one, 6-(2,6-diMethylphenyl)-2-[[4-(4-Methyl-1-piperazinyl)phenyl]aMino]- Preparation Products And Raw materials

Raw materials

Preparation Products

PyriMido[5',4':5,6]pyriMido[1,2-a]benziMidazol-5(6H)-one, 6-(2,6-diMethylphenyl)-2-[[4-(4-Methyl-1-piperazinyl)phenyl]aMino]- Suppliers

Global( 72)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32376 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8467 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7552 61
AdooQ BioScience, LLC +1 (866) 930-6790 info@adooq.com United States 2782 58
SPIRO PHARMA eric_feng1954@126.com China 9248 55
Guangzhou QiYun Biotechnology Co., Ltd. 020-61288194 61288195 505721671@qq.com China 3866 58
Shanghai Chaolan Chemical Technology Center 021-QQ：65489617 15618227136 Sales@ATKchemical.com China 9364 58
Beijing Solarbio Science & Tecnology Co., Ltd. 010-50973130 17801761073 3193328036@qq.com China 29763 68
Supplier Advantage
TargetMol Chemicals Inc. 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58
Haoyuan Chemexpress Co., Ltd. 61
AdooQ BioScience, LLC 58
SPIRO PHARMA 55
Guangzhou QiYun Biotechnology Co., Ltd. 58
Shanghai Chaolan Chemical Technology Center 58
Beijing Solarbio Science & Tecnology Co., Ltd. 68

847950-09-8(PyriMido[5',4':5,6]pyriMido[1,2-a]benziMidazol-5(6H)-one, 6-(2,6-diMethylphenyl)-2-[[4-(4-Methyl-1-piperazinyl)phenyl]aMino]-)Related Search:

N-Methylaniline Dimethyl N,N-Dimethylaniline Phenylsilane Lck Inhibitor
PyriMido[5',4':5,6]pyriMido[1,2-a]benziMidazol-5(6H)-one, 6-(2,6-diMethylphenyl)-2-[[4-(4-Methyl-1-piperazinyl)phenyl]aMino]- Lck Inhibitor 6-(2,6-Dimethylphenyl)-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-one 6-(2,6-Dimethylphenyl)-2-[[4-(4-methyl-1-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-one TC-S 7003 (Lck Inhibitor) Lck Inhibitor 25 847950-09-8 C31H30N8O