3-Fluoro-2-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzonitrile
- CAS No.
- 624741-47-5
- Chemical Name:
- 3-Fluoro-2-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzonitrile
- Synonyms
- Butylhydroxyanisole Impurity 11;6-Cyano-2-fluorobenzeneboronicacidpinacolester,96%;(2-CYANO-6-FLUOROPHENYL)BORONIC ACID PINACOL ESTER;6-Cyano-2-fluorobenzeneboronic acid pinacol ester, 96%;3-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)ben;3-Fluoro-2-(tetraMethyl-1,3,2-dioxaborolan-2-yl)benzonitrile;Benzonitrile, 3-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
- CBNumber:
- CB72640757
- Molecular Formula:
- C13H15BFNO2
- Molecular Weight:
- 247.07
- MDL Number:
- MFCD18729920
- MOL File:
- 624741-47-5.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| HS Code | 2931900090 | |||||||||
| NFPA 704 |
|
3-Fluoro-2-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzonitrile price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | F598643 | 3-Fluoro-2-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile | 624741-47-5 | 100mg | $65 | 2021-12-16 | Buy |
| AK Scientific | V6953 | 3-Fluoro-2-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile | 624741-47-5 | 1g | $317 | 2021-12-16 | Buy |
| Matrix Scientific | 092681 | 3-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile 95+% | 624741-47-5 | 250mg | $341 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | BOR0006622 | 3-FLUORO-2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZONITRILE 95.00% | 624741-47-5 | 1G | $573.3 | 2021-12-16 | Buy |
| Matrix Scientific | 092681 | 3-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile 95+% | 624741-47-5 | 1g | $756 | 2021-12-16 | Buy |
3-Fluoro-2-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzonitrile Chemical Properties,Uses,Production
Synthesis
73183-34-3
425379-16-4
624741-47-5
2-Bromo-3-fluorobenzonitrile (1.20 g, 6.00 mmol), dried potassium acetate (1.18 g, 12.0 mmol) and bis(pinacolato)diboron (1.75 g, 6.89 mmol) were mixed in 1,4-dioxane (14.7 ml). The mixture was degassed by nitrogen bubbling for 50 min, followed by addition of dimethyl sulfoxide (0.3 ml). Dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct (0.1481 g, 0.181 mmol) was then added and again degassed for 10 min. The reaction mixture was heated at 90°C for 18 hours in a nitrogen atmosphere. After completion of the reaction, it was cooled to room temperature, filtered through glass fiber paper and the solids were washed with a small amount of dichloromethane. The filtrates were combined and concentrated by vacuum evaporation. The residue was partitioned between 2M NaOH aqueous solution (21 ml) and ether (20 ml). The aqueous layer was acidified to pH 5 with concentrated hydrochloric acid (3 ml) to induce precipitation of the solid. The mixture was allowed to stand in a refrigerator for 3 days, the precipitate was collected by filtration, washed with water and dried in vacuum to give 6-cyano-2-fluorophenylboronic acid pinacol ester (0.9191 g, 62%) as a white solid. The product was characterized by 1H NMR (360 MHz, DMSO-d6): δ 1.34 (12H, s), 7.55-7.59 (1H, m), 7.69-7.75 (2H, m).
References
[1] Patent: WO2003/93272, 2003, A1. Location in patent: Page/Page column 37
[2] Organic Letters, 2011, vol. 13, # 6, p. 1366 - 1369
3-Fluoro-2-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
3-Fluoro-2-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzonitrile Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
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| Aceschem Inc. | +1-817863-6948 +1-（817）863-6948 | sales@aceschem.com | United States | 19632 | 58 |
| Shanghai Scochem Technology Co., Ltd | +86-021-33758897 +86-13701882790 | sales@scochem.com | China | 1977 | 58 |
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| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Allfluoro pharmaceutical co. ltd. | +86-400-0216110 +86-15958047586 | sales@allfluoro.com | China | 11385 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30123 | 84 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9498 | 58 |
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