5-Fluoro-2-hydroxybenzonitrile
- CAS No.
- 91407-41-9
- Chemical Name:
- 5-Fluoro-2-hydroxybenzonitrile
- Synonyms
- 2-Cyano-4-fluorophenol;5-Fluoro-2-hydroxybenzonitrile;2-hydroxy-5-fluorobenzonitrile;Benzonitrile, 5-fluoro-2-hydroxy-
- CBNumber:
- CB72640924
- Molecular Formula:
- C7H4FNO
- Molecular Weight:
- 137.11
- MDL Number:
- MFCD11846513
- MOL File:
- 91407-41-9.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319-H335 |
| Precautionary statements | P271-P260-P280 |
| HS Code | 2926907090 |
5-Fluoro-2-hydroxybenzonitrile price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS27528 | 5-Fluoro-2-hydroxybenzonitrile 98% | 91407-41-9 | 1g | $35 | 2026-06-04 | Buy |
| Activate Scientific | AS27528 | 5-Fluoro-2-hydroxybenzonitrile 98% | 91407-41-9 | 5g | $143 | 2026-06-04 | Buy |
| Activate Scientific | AS27528 | 5-Fluoro-2-hydroxybenzonitrile 98% | 91407-41-9 | 25g | $324 | 2026-06-04 | Buy |
| Matrix Scientific | 076820 | 5-Fluoro-2-hydroxybenzonitrile | 91407-41-9 | 1.00g | $195 | 2026-05-18 | Buy |
| Matrix Scientific | 076820 | 5-Fluoro-2-hydroxybenzonitrile | 91407-41-9 | 5.00g | $720 | 2026-05-18 | Buy |
5-Fluoro-2-hydroxybenzonitrile Chemical Properties, Uses, Production
Synthesis
![4-Fluoro-2-[(1E)-(hydroxyiMino)Methyl]phenol](/CAS/20150408/GIF/91407-40-8.gif)
91407-40-8
91407-41-9
5-Fluoro-2-hydroxybenzaldehyde oxime (920 mg, 5.93 mmol) was used as a raw material and dissolved in acetic anhydride (15 mL). Subsequently, a solution consisting of KOH (2 g) dissolved in H2O (10 mL) and ethanol (10 mL) was added to the mixture. The reaction mixture was heated at 80 °C for 2 h, after which it was cooled to room temperature. The pH of the reaction solution was adjusted to 7 with 6N HCl and then extracted twice with a solvent mixture of isopropanol/dichloromethane (1:3, v/v). The organic layers were combined and dried with anhydrous sodium sulfate. The resulting residue was purified by silica gel column chromatography using hexane/ethyl acetate (5:1, v/v) as eluent to afford the target product 2-hydroxy-5-fluorobenzonitrile (800 mg, 100% yield). The mass spectrum (DCI/NH3) showed m/z 136 (M + 1)+. 1H NMR (500 MHz, DMSO-d6) δ ppm: 6.99 (dd, J = 9.05, 4.37 Hz, 1H), 7.36 (td, J = 9.05, 3.12 Hz, 1H), 7.53 (dd, J = 8.42, 3.43 Hz, 1H). 11.04 (m, 1H).
References
[1] Patent: WO2005/111003, 2005, A1. Location in patent: Page/Page column 131
[2] Patent: EP2258697, 2010, A1. Location in patent: Page/Page column 40
[3] Patent: CN107778216, 2018, A. Location in patent: Paragraph 0023; 0024
[4] Patent: CN107778215, 2018, A. Location in patent: Paragraph 0023; 0024
5-Fluoro-2-hydroxybenzonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
5-Fluoro-2-hydroxybenzonitrile Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 18201 | 56 |
| Tianjin Ji Ping Jia Chemical Co., Ltd. | 18622448868 | jpjchem@163.com | China | 473 | 62 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Sichuan Yuehe Bio-Pharmaceutical Co.,Ltd | 028-82729560 17365561851 | tangzhichen@yuehepharm.com | China | 212 | 58 |
| Mashilabs (Shanghai) Co.,Ltd. | 19916721580 | mafarm@126.com | China | 4534 | 58 |
| Nanjing ERan Biological Pharmaceutical Co., Ltd. | 13770809694 | googlexu_0114@sina.com | China | 992 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
