BVT 2733
- CAS No.
- 376640-41-4
- Chemical Name:
- BVT 2733
- Synonyms
- BVT2733, >98%;BVT 2733(BVT.2733);BVT.2733 >=98% (HPLC);BVT 2733, 10 mM in DMSO;3-chloro-2-methyl-N-(4-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)thiazol-2-yl)benzenesulfonamide;3-chloro-2-methyl-N-[4-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-2-thiazolyl]-benzenesulfonamide;BENZENESULFONAMIDE, 3-CHLORO-2-METHYL-N-[4-[2-(4-METHYL-1-PIPERAZINYL)-2-OXOETHYL]-2-THIAZOLYL]-;3-CHLORO-2-METHYL-N-[4-[2-(4-METHYLPIPERAZIN-1-YL)-2-OXOETHYL]-1,3-THIAZOL-2-YL]BENZENESULFONAMIDE;HFD,CIA,BVT-2733,J774.1,arthritis,macrophage,collagen,inhibit,BVT2733,BVT 2733,disease,adipocyte,Inhibitor,obesity
- CBNumber:
- CB72667358
- Molecular Formula:
- C17H21ClN4O3S2
- Molecular Weight:
- 428.96
- MDL Number:
- MFCD13152134
- MOL File:
- 376640-41-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 636.9±65.0 °C(Predicted) |
|---|---|
| Density | 1.427±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | ≥42.9 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
| form | solid |
| pka | 6.36±0.10(Predicted) |
| color | Off-white to pink |
| InChI | 1S/C17H21ClN4O3S2/c1-12-14(18)4-3-5-15(12)27(24,25)20-17-19-13(11-26-17)10-16(23)22-8-6-21(2)7-9-22/h3-5,11H,6-10H2,1-2H3,(H,19,20) |
| InChIKey | YDPRNGAPPNPYQQ-UHFFFAOYSA-N |
| SMILES | O=S(C1=C(C)C(Cl)=CC=C1)(NC2=NC(CC(N3CCN(C)CC3)=O)=CS2)=O |
| FDA UNII | 2EGD70329U |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| HS Code | 2935909099 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
|
BVT 2733 price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1205 | BVT.2733 ≥98% (HPLC) | 376640-41-4 | 25MG | $347 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML1205 | BVT.2733 ≥98% (HPLC) | 376640-41-4 | 5MG | $121 | 2025-07-31 | Buy |
| Cayman Chemical | 22203 | BVT 2733 ≥98% | 376640-41-4 | 5mg | $99 | 2026-04-30 | Buy |
| Cayman Chemical | 22203 | BVT 2733 ≥98% | 376640-41-4 | 10mg | $189 | 2026-04-30 | Buy |
| Cayman Chemical | 22203 | BVT 2733 ≥98% | 376640-41-4 | 25mg | $440 | 2026-04-30 | Buy |
BVT 2733 Chemical Properties, Uses, Production
Uses
BVT 2733 is a selective inhibitor of 11β-hydroxysteroid dehydrogenase type 1.
Biological Activity
ki: 1 μm using 11-dehydrocorticosterone as substratebvt 2733 is a novel, small molecule, non-steroidal, and selective inhibitor of 11beta-hydroxysteroid dehydrogenase type 1 (11β-hsd1).11β-hsd1 has been reported to alter glucocorticoid hormone action in target tissues for insulin action and is suggested to play a key role in glucose homeostasis.
in vitro
bvt 2733 was identified as a novel type 1 selective inhibitor of murine 11β-hsd1 (ki 1 μmol/l), which did not inhibit mouse 11β-hsd type 2 at a concentration as high as 200 μmol/l (corresponding to a ki >33 μmol/l). therefore, the selectivity of bvt 2733 for the 11β-hsd type 1 enzyme over the type 2 enzyme was estimated to be at least 30-fold based on the ki values [1].
in vivo
in mice, bvt 2733 treatment could lower hepatic pepck and glucose-6-phosphatase mrna, serum insulin and blood glucose concentrations compared with vehicle treated mice. in contrast, hepatic 11beta-hydroxysteroid dehydrogenase type 1 mrna, liver function marker enzyme expression including alanine aminotransferase, aspartate aminotransferase and alkaline phosphatases, body weight as well as daily food intake were not changed by the treatment of bvt 2733 [1].
References
[1] alberts p,engblom l,edling n,forsgren m,klingstrm g,larsson c,rnquist-nii y,ohman b,abrahmsén l. selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice. diabetologia.2002 nov;45(11):1528-32.
BVT 2733 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| Shanghai JiYi Biotechnology Co. Ltd. | 13621943973 | sales@shjiyipharmatech.com | China | 1166 | 55 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| D&C Chemicals | +86-21-58447131 | 1724405207@qq.com | China | 470 | 55 |
| ShangHai Siyan Biological Technology Co., Ltd. | 021-50908862，442785678，326799392 18721037013 | siyansales@126.com | China | 9612 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Guangzhou QiYun Biotechnology Co., Ltd. | 020-61288194 61288195 | 505721671@qq.com | China | 3853 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai QianYan Bio-technology Co., Ltd | 02781293128 | orders@biochemsafebuy.com | China | 9904 | 55 |
View Latest Price from BVT 2733 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-14 | BVT 2733
376640-41-4
|
$37.00-125.00 | 99.64% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-09-06 | 3-chloro-2-methyl-N-(4-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)thiazol-2-yl)benzenesulfonamide
376640-41-4
|
$1.00 | 1KG | 95%~99% | Career Henan Chemical Co |
-
- BVT 2733
376640-41-4
- $37.00-125.00
- 99.64%
- TargetMol Chemicals Inc.
-
- 3-chloro-2-methyl-N-(4-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)thiazol-2-yl)benzenesulfonamide
376640-41-4
- $1.00
- 95%~99%
- Career Henan Chemical Co
