Entacapone (sodiuM salt)
- CAS No.
- 1047659-02-8
- Chemical Name:
- Entacapone (sodiuM salt)
- Synonyms
- Entacapone Sodium;Entacapone (sodiuM salt);Sodium (E)-4-(2-cyano-3-(diethylamino)-3-oxoprop-1-en-1-yl)-2-hydroxy-6-nitrophenolate
- CBNumber:
- CB72681998
- Molecular Formula:
- C14H14N3NaO5
- Molecular Weight:
- 329.29
- MDL Number:
- MFCD28346924
- MOL File:
- 1047659-02-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501 |
Entacapone (sodiuM salt) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | XRB65902 | Entacapone sodium | 1047659-02-8 | 10mg | $762 | 2026-06-05 | Buy |
| Biosynth | XRB65902 | Entacapone sodium | 1047659-02-8 | 25mg | $1429 | 2026-06-05 | Buy |
| Biosynth | XRB65902 | Entacapone sodium | 1047659-02-8 | 50mg | $1988.5 | 2026-06-05 | Buy |
| ApexBio Technology | B1090 | Entacapone sodium salt | 1047659-02-8 | 10mg | $56 | 2026-05-06 | Buy |
| ApexBio Technology | B1090 | Entacapone sodium salt | 1047659-02-8 | 100mg | $166 | 2026-05-06 | Buy |
Entacapone (sodiuM salt) Chemical Properties, Uses, Production
Uses
Entacapone sodium salt is a potent, reversible, peripherally acting and orally active catechol-O-methyltransferase (COMT) inhibitor. Entacapone sodium salt inhibits COMT from rat brain, erythrocytes and liver with IC50 values of 10 nM, 20 nM, and 160 nM, respectively. Entacapone sodium salt is selective for COMT over other catecholamine metabolizing enzymes, including MAO-A, MAO-B, phenolsulphotransferase M (PST-M) and PST-P (IC50s>50 μM). Entacapone sodium salt can be used for the research of Parkinson's disease[1]. Entacapone sodium salt serves as as a inhibit of FTO demethylation with an IC50 of 3.5 μM, can be used for the research of metabolic disorders[2].
in vivo
Entacapone sodium salt (oral administration; 600 mg/kg per day; 3-9 weeks) results in a dose-response effect dose-response effect. After 3 weeks, mouse body weight are decreased by 10.1% compared to controls, and shows similar food intakefat mass and fat mass ratio reduced after Entacapone sodium salt treatment. Entacapone sodium salt also increases the energy expenditure of mice: reductions in total cholesterol (17.6%), low-density lipoprotein cholesterol (31.0%), and triglycerides (10.2%) in mice[2].
References
[1] E Nissinen, et al. Biochemical and pharmacological properties of a peripherally acting catechol-O-methyltransferase inhibitor Entacapone sodium salt . Naunyn Schmiedebergs Arch Pharmacol. 1992 Sep;346(3):262-6. DOI:10.1007/BF00173538
[2] Shiming Peng, et al. Identification of Entacapone sodium salt as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1. Sci Transl Med DOI:10.1126/scitranslmed.aau7116
Entacapone (sodiuM salt) Preparation Products And Raw materials
Raw materials
Preparation Products
Entacapone (sodiuM salt) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9909 | 65 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | sales@linyuepharm.com | China | 5731 | 55 |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4648 | 60 |
| Chengdu Saint - Kay Biotechnology Co., Ltd. | 028-85157043 15882256948 | 676046971@qq.com | China | 4183 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Jinan ponder chemical co. LTD | 0531-0000 | thinklifescience@163.com | China | 19684 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8137 | 58 |
View Latest Price from Entacapone (sodiuM salt) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-21 | Entacapone sodium salt
1047659-02-8
|
$1520.00-2500.00 | 10g | TargetMol Chemicals Inc. | |||
 |
2025-07-19 | Entacapone sodium salt
1047659-02-8
|
$1520.00-2500.00 | 10g | TargetMol Chemicals Inc. |
-
- Entacapone sodium salt
1047659-02-8
- $1520.00-2500.00
- TargetMol Chemicals Inc.
-
- Entacapone sodium salt
1047659-02-8
- $1520.00-2500.00
- TargetMol Chemicals Inc.
