GSK 2830371
- CAS No.
- 1404456-53-6
- Chemical Name:
- GSK 2830371
- Synonyms
- GSK 2830371;GSK 2830371 USP/EP/BP;GSK 2830371, 10 mM in DMSO;PPM1D Phosphatase Inhibitor II, GSK2830371;(S)-5-((5-chloro-2-methylpyridin-3-ylamino)methyl)-N-(3-cyclopentyl-1-(cyclopropylamino)-1-oxopropan-2-yl)thiophene-2-carboxamide;5-[[(5-Chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cycloprpylamino)-2-oxoethyl]-2-thiophenecarboxamide;5-[[(5-Chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cyclopropylamino)-2-oxoethyl]-2-thiophenecarboxamide;2-Thiophenecarboxamide, 5-[[(5-chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cyclopropylamino)-2-oxoethyl]-;GSK 2830371 (S)-5-(((5-chloro-2-methylpyridin-3-yl)amino)methyl)-N-(3-cyclopentyl-1-(cyclopropylamino) -1-oxopropan-2-yl)thiophene-2-carboxamide
- CBNumber:
- CB72682001
- Molecular Formula:
- C23H29ClN4O2S
- Molecular Weight:
- 461.02
- MDL Number:
- MFCD28009442
- MOL File:
- 1404456-53-6.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| GSK2830371 ≥98% (HPLC) | SML1048 | 5mg | $132 |
| GSK2830371 ≥98% (HPLC) | SML1048 | 25mg | $489 |
| GSK2830371 ≥98% | 16973 | 1mg | $32 |
| GSK2830371 ≥98% | 16973 | 5mg | $100 |
| GSK2830371 ≥98% | 16973 | 10mg | $184 |
| Boiling point | 704.1±60.0 °C(Predicted) |
|---|---|
| Density | 1.30±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble20mg/mL, clear |
| form | powder |
| pka | 13.29±0.46(Predicted) |
| color | white to beige |
| InChIKey | IVDUVEGCMXCMSO-FQEVSTJZSA-N |
| SMILES | [s]1c(ccc1C(=O)N[C@@H](CC4CCCC4)C(=O)NC3CC3)CNc2c(ncc(c2)Cl)C |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
GSK 2830371 price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1048 | GSK2830371 ≥98% (HPLC) | 1404456-53-6 | 5mg | $132 | 2025-07-31 | Buy |
| Sigma-Aldrich | SML1048 | GSK2830371 ≥98% (HPLC) | 1404456-53-6 | 25mg | $489 | 2025-07-31 | Buy |
| Cayman Chemical | 16973 | GSK2830371 ≥98% | 1404456-53-6 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 16973 | GSK2830371 ≥98% | 1404456-53-6 | 5mg | $100 | 2024-03-01 | Buy |
| Cayman Chemical | 16973 | GSK2830371 ≥98% | 1404456-53-6 | 10mg | $184 | 2024-03-01 | Buy |
GSK 2830371 Chemical Properties,Uses,Production
Uses
GSK 2830371 is used in biological studies as allosteric Wip1(wild-type p54-induced phosphatase) inhibition through flap-subdomain interaction.
Biochem/physiol Actions
GSK2830371 is an orally active allosteric inhibitor of wild-type p53-induced phosphatase (Wip1, also known as PPM1D/ PP2Cδ), an oncogenic type 2C serine/threonine phosphatase that negatively regulates key proteins in the DNA damage–response pathway. GSK2830371 is selective for Wip1 with an IC50 of 6 nM against Wip1 compared to >10 μM IC50 for PPM1A & PPM1K, and >30 μM IC50 for 22 other phosphatases tested. GSK2830371 is believed to interact with the flap subdomain located near the Wip1 catalytic site, a feature that distinguishes Wip1 from other members of the protein phosphatase 2C (PP2C) family. GSK2830371 increased phosphorylation of Wip1 substrates and caused growth inhibition in both hematopoietic tumor cell lines and Wip1-amplified breast tumor cells harboring wild-type TP53.
in vivo
In a pharmacodynamic assay, orally administered GSK 2830371 increases phosphorylation of Chk2 (T68) and p53 (S15) and decreased Wip1protein concentrations in DOHH2 tumors. Following 14 d of oral dosing at 150 mg per kg body weight, BID (twice daily) and TID (thrice daily), GSK 2830371 inhibits the growth of DOHH2 tumor xenografts by 41% and 68%, respectively. Comparable tumor growth inhibition is observed in mice treated BID with either 75 or 150 mg per kg body weight. Greater tumor growth inhibition with the TID schedule is consistent with a short half-life of GSK 2830371 in mice and suggests that sustained inhibition of Wip1 may be required for maximal antitumor effect[1].
storage
Store at -20°C
GSK 2830371 Preparation Products And Raw materials
GSK 2830371 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32469 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 18866 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 24597 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39043 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
View Lastest Price from GSK 2830371 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-13 | GSK 2830371
1404456-53-6
|
US $48.00-153.00 / mg | 99.85% | 10g | TargetMol Chemicals Inc. |
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- GSK 2830371
1404456-53-6
- US $48.00-153.00 / mg
- 99.85%
- TargetMol Chemicals Inc.
