2-Benzyloxy-3-dibenzylaMino-5-fluoro-6-Methyl-benzoic acid phenyl ester
- CAS No.
- 1253799-29-9
- Chemical Name:
- 2-Benzyloxy-3-dibenzylaMino-5-fluoro-6-Methyl-benzoic acid phenyl ester
- Synonyms
- EOS-61973;TP-353, 10 mM in DMSO;Eravacycline intermediate D;2-(Benzyloxy)-3-(benzylamino)-5-fluorine-6-Methylbenzoic acid;2- (benzyloxy) -3- (benzylamino) -5-fluoro-6-methylbenzoic acid;2-Benzyloxy-3-dibenzylaMino-5-fluoro-6-Methyl-benzoic acid phenyl ester;phenyl 2-(benzyloxy)-3-(dibenzylamino)-5-fluoro-6-methylbenzoate TP-353;3-[Bis(phenylmethyl)amino]-5-fluoro-6-methyl-2-(phenylmethoxy)benzoic acid phenyl ester;Benzoic acid, 3-[bis(phenylmethyl)amino]-5-fluoro-6-methyl-2-(phenylmethoxy)-, phenyl ester
- CBNumber:
- CB72682632
- Molecular Formula:
- C35H30FNO3
- Molecular Weight:
- 531.62
- MDL Number:
- MFCD28142365
- MOL File:
- 1253799-29-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Phenyl2-(Benzyloxy)-3-(dibenzylamino)-5-fluoro-6-methylbenzoate | P399543 | 5mg | $60 |
| Phenyl2-(benzyloxy)-3-(dibenzylamino)-5-fluoro-6-methylbenzoate | 2930DV | 100mg | $347 |
| PHENYL 2-(BENZYLOXY)-3-(DIBENZYLAMINO)-5-FLUORO-6-METHYLBENZOATE 95.00% | HCH0418622 | 5MG | $496.31 |
| Phenyl2-(benzyloxy)-3-(dibenzylamino)-5-fluoro-6-methylbenzoate | 1253799299 | 1g | $400 |
| Phenyl2-(benzyloxy)-3-(dibenzylamino)-5-fluoro-6-methylbenzoate 95+% | CM248497 | 1g | $262 |
| More product size | |||
| Boiling point | 695.5±55.0 °C(Predicted) |
|---|---|
| Density | 1?+-.0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 2.69±0.50(Predicted) |
| InChIKey | VRXGVVAMXZXKNA-UHFFFAOYSA-N |
| SMILES | C(OC1=CC=CC=C1)(=O)C1=C(C)C(F)=CC(N(CC2=CC=CC=C2)CC2=CC=CC=C2)=C1OCC1=CC=CC=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H332-H312 |
| Precautionary statements | P280-P302+P352-P312-P322-P363-P501-P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501 |
2-Benzyloxy-3-dibenzylaMino-5-fluoro-6-Methyl-benzoic acid phenyl ester price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | P399543 | Phenyl2-(Benzyloxy)-3-(dibenzylamino)-5-fluoro-6-methylbenzoate | 1253799-29-9 | 5mg | $60 | 2021-12-16 | Buy |
| AK Scientific | 2930DV | Phenyl2-(benzyloxy)-3-(dibenzylamino)-5-fluoro-6-methylbenzoate | 1253799-29-9 | 100mg | $347 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0418622 | PHENYL 2-(BENZYLOXY)-3-(DIBENZYLAMINO)-5-FLUORO-6-METHYLBENZOATE 95.00% | 1253799-29-9 | 5MG | $496.31 | 2021-12-16 | Buy |
| Alichem | 1253799299 | Phenyl2-(benzyloxy)-3-(dibenzylamino)-5-fluoro-6-methylbenzoate | 1253799-29-9 | 1g | $400 | 2021-12-16 | Buy |
| Chemenu | CM248497 | Phenyl2-(benzyloxy)-3-(dibenzylamino)-5-fluoro-6-methylbenzoate 95+% | 1253799-29-9 | 1g | $262 | 2021-12-16 | Buy |
2-Benzyloxy-3-dibenzylaMino-5-fluoro-6-Methyl-benzoic acid phenyl ester Chemical Properties,Uses,Production
Uses
Phenyl 2-(benzyloxy)-3-(dibenzylamino)-5-fluoro-6-methylbenzoate (CAS# 1253799-29-9) is most frequently used as a building block in the synthesis of tetracycline antibiotics.
Synthesis
1207284-89-6
100-39-0
1253799-29-9
To a solution of 500 g of the compound (CAS:1207284-89-6) in 4.25 L of N-methylpyrrolidone was added N,N-diisopropylethylamine (620 mL), followed by benzyl bromide (425 mL, 2.5 equiv). The reaction mixture was heated at 100 °C for 18 h, after which it was cooled to 80 °C and treated with 25% w/w aqueous triethylamine solution for 10 min. The mixture was stirred at room temperature for 25 minutes and subsequently cooled to 15 °C and water (10 L) was added to precipitate the product. After 3 h of precipitation, the resulting light-colored suspension was filtered and washed with 2 L of water and subsequently dried. The crude product (750 g) was dissolved in 4.1 L of toluene and filtered through silica gel to give 762 g of yellow solid. This solid was recrystallized by acetone/heptane to give a final 606 g of the target compound 2-(benzyloxy)-3-(benzylamino)-5-fluoro-6-methylbenzoic acid (80% yield) as a white solid. Its 1H NMR (400 MHz, CDCl3) data were as follows: δ 7.48-7.03 (m, 20H), 6.60 (d, J=11.5 Hz, 1H), 5.31 (s, 2H), 4.33 (s, 4H), 2.30 (s, 3H).
References
[1] Patent: WO2010/126607, 2010, A2. Location in patent: Page/Page column 172/251
2-Benzyloxy-3-dibenzylaMino-5-fluoro-6-Methyl-benzoic acid phenyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13456 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 12081 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32434 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15142 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| Shanghai Likang New Materials Co., Limited | +86-16631818819 +86-17736933208 | 3684455296@qq.com | China | 9300 | 58 |
| Shenzhen Nexcon Pharmatechs Ltd. | +86-0755-89396905 +86-18025329037 | admin@nexconn.com | China | 3147 | 58 |
