Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>(S)-(+)-Glycidyl Phthalimide

(S)-(+)-Glycidyl Phthalimide

(S)-(+)-Glycidyl Phthalimide Structure
(S)-(+)-Glycidyl Phthalimide structure
CAS No.
161596-47-0
Chemical Name:
(S)-(+)-Glycidyl Phthalimide
Synonyms
PHTHAL;(S)-N-Glycidylphthalimide;(S)-2-OXIRANYLMETHYL-ISOINDOLE-1,3-DIONE;S-Glycidyl Phthalamide;2-[[(2S)-oxiran-2-yl]methyl]isoindoline-1,3-dione;2-[(2S)-ox;(S)-(+)-GL;2-Amino-8-picoline;Rivaroxaban Impurity R;Linezolid EPP Impurity
CBNumber:
CB7273483
Molecular Formula:
C11H9NO3
Molecular Weight:
203.19
MDL Number:
MFCD04973350
MOL File:
161596-47-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-12 09:10:49
Product description Number Pack Size Price
(S)-(+)-N-(2,3-Epoxypropyl)phthalimide ≥99.0% (GC) 671606 1g $31.4
(S)-N-Glycidylphthalimide >98.0%(GC) G0328 5g $44
(S)-N-Glycidylphthalimide >98.0%(GC) G0328 25g $126
(S)-N-Glycidylphthalimide ≥98%(GC) 39547 5G $45.37
(S)-N-Glycidylphthalimide ≥98%(GC) 39547 25G $155.53
More product size
Request For Quotation

(S)-(+)-Glycidyl Phthalimide Properties

Melting point 102 °C
Boiling point 347.4±15.0 °C(Predicted)
Density 1.446±0.06 g/cm3(Predicted)
vapor pressure 0.001-2.17Pa at 25-90.25℃
refractive index 10 ° (C=2.2, CHCl3)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility Chloroform (Slightly), Ethyl Acetate (Slightly)
pka -2.24±0.20(Predicted)
form Solid
color White
optical activity Consistent with structure
InChI InChI=1S/C11H9NO3/c13-10-8-3-1-2-4-9(8)11(14)12(10)5-7-6-15-7/h1-4,7H,5-6H2/t7-/m0/s1
InChIKey DUILGEYLVHGSEE-ZETCQYMHSA-N
SMILES C1(=O)C2=C(C=CC=C2)C(=O)N1C[C@H]1CO1
LogP 1.2 at 40℃
FDA UNII 9GA7C6L4S5
UNSPSC Code 12352111
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS05,GHS08
Signal word  Danger
Hazard statements  H318-H341
Precautionary statements  P201-P202-P305+P351+P338+P310-P308+P313-P405-P501-P280-P305+P351+P338
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  41
Safety Statements  26-39
WGK Germany  2
HS Code  29252900
Storage Class 13 - Non Combustible Solids
Hazard Classifications Eye Dam. 1
REACH Registrations Active
NFPA 704
0
2 0

(S)-(+)-Glycidyl Phthalimide price More Price(47)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 671606 (S)-(+)-N-(2,3-Epoxypropyl)phthalimide ≥99.0% (GC) 161596-47-0 1g $31.4 2023-06-20 Buy
TCI Chemical G0328 (S)-N-Glycidylphthalimide >98.0%(GC) 161596-47-0 5g $44 2026-04-30 Buy
TCI Chemical G0328 (S)-N-Glycidylphthalimide >98.0%(GC) 161596-47-0 25g $126 2026-04-30 Buy
Chem-Impex 39547 (S)-N-Glycidylphthalimide ≥98%(GC) 161596-47-0 5G $45.37 2026-05-19 Buy
Chem-Impex 39547 (S)-N-Glycidylphthalimide ≥98%(GC) 161596-47-0 25G $155.53 2026-05-19 Buy
Product number Packaging Price Buy
671606 1g $31.4 Buy
G0328 5g $44 Buy
G0328 25g $126 Buy
39547 5G $45.37 Buy
39547 25G $155.53 Buy

(S)-(+)-Glycidyl Phthalimide Chemical Properties,Uses,Production

Chemical Properties

White powder

Uses

(S)-(+)-Glycidyl Phthalimide is a phthalimide derivative used as an intermediate in the preparation of the antibiotic Linezolid (L466500). It is also a key intermediate of rivaroxaban.

Application

(S)-(+)-glycidyl phthalimide is primarily used as a key chiral intermediate in the synthesis of rivaroxaban, a structural unit for linezolid and antifungal thiazolidinones/oxazolidinones, a reference standard for rivaroxaban impurity 92 in quality control, and a chiral source for the synthesis of complex organic molecules with chiral hydroxyl/amino groups.

Synthesis

Phthalimide and (S)-1-substituent propylene oxide are used as raw materials, a reaction occurs under the action of a catalyst to generate 2-((S)-3-substituent-2-hydroxypropyl isodihydroindole-1,3-dione, and finally (S)-glycidyl phthalimide is generated by means of a ring-closure reaction.
(S)-( )-GLYCIDYL PHTHALIMIDE

References

[1] Patent: WO2004/112787, 2004, A1. Location in patent: Page 17-18
[2] Patent: WO2004/113301, 2004, A1. Location in patent: Page 18
[3] Tetrahedron Asymmetry, 1996, vol. 7, # 6, p. 1641 - 1648
[4] Heterocycles, 2006, vol. 67, # 2, p. 561 - 566
[5] Chemical communications (Cambridge, England), 2003, # 4, p. 468 - 469

(S)-(+)-Glycidyl Phthalimide synthesis

148857-42-5
161596-47-0
Synthesis of (S)-(+)-Glycidyl Phthalimide from (S)-2-(3-chloro-2-hydroxypropyl)isoindoline-1,3-dione

(S)-(+)-Glycidyl Phthalimide Preparation Products And Raw materials

Raw materials

(S)-2-(3-chloro-2-hydroxypropyl)isoindoline-1,3-dione 1H-Isoindol-1-one, 3-hydroxy- (S)-Oxiranemethanol (S)-(+)-Epichlorohydrin (R)-(-)-Epichlorohydrin
Potassium phthalimide (R)-(+)-Glycidol Triphenylphosphine Diethyl azodicarboxylate Tetrahydrofuran

1of2

Preparation Products

2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione

(S)-(+)-Glycidyl Phthalimide Suppliers

Global( 673)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Rochi Pharmaceutical Co.,Ltd.
21-38751876 +8615000076078 info@rochipharma.com China 505 58
Hefei TianRui Pharmaceutical Chemical Co., Ltd.
+86-0551-68665055 +86-+86-18616906106 sales@trywchem.com China 187 58
Beijing Mediking Biopharm Co., Ltd
+undefined15901403431 sales01@mediking.cn China 150 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-86-13131129325 +8613131129325 sales1@chuanghaibio.com China 5233 58
Henan Bao Enluo International TradeCo.，LTD 		+86-17331933971 deasea125996@gmail.com China 2472 58
Anhui Ruihan Technology Co., Ltd 		+8617756083858 daisy@anhuiruihan.com China 973 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20124 58
airuikechemical co., ltd. 		+86-18353166132 sales02@airuikechemical.com China 983 58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD 		+86-15350851019; +8615350851019 admin@86-ss.com China 999 58
Handan City Zechi trading Co., LTD 		+8619003396151 13165586887@163.com China 475 58
Supplier Advantage
Shanghai Rochi Pharmaceutical Co.,Ltd.
58
Hefei TianRui Pharmaceutical Chemical Co., Ltd.
58
Beijing Mediking Biopharm Co., Ltd
58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Henan Bao Enluo International TradeCo.，LTD 		58
Anhui Ruihan Technology Co., Ltd 		58
Henan Fengda Chemical Co., Ltd 		58
airuikechemical co., ltd. 		58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD 		58
Handan City Zechi trading Co., LTD 		58

View Lastest Price from (S)-(+)-Glycidyl Phthalimide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(S)-(+)-N-(2,3-Epoxypropyl)phthalimide pictures 2026-05-25 (S)-(+)-N-(2,3-Epoxypropyl)phthalimide
161596-47-0
 US $0.00 / g 1g 98.0% 10kg/month WUHAN FORTUNA CHEMICAL CO., LTD
(S)-(+)-Glycidyl Phthalimide pictures 2026-05-24 (S)-(+)-Glycidyl Phthalimide
161596-47-0
 US $100.00-75.00 / kg 1kg 99% 5000Ton HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
(S)-N-Glycidylphthalimide pictures 2026-05-11 (S)-N-Glycidylphthalimide
161596-47-0
 US $0.00 / removed 99.46% 10g TargetMol Chemicals Inc.

(S)-(+)-Glycidyl Phthalimide Spectrum

(S)-(+)-GLYCIDYL PHTHALIMIDE(161596-47-0)1HNMR

161596-47-0((S)-(+)-Glycidyl Phthalimide)Related Search:

N-(Chloromethyl)phthalimide 4-(4-AMINOPHENYL)MORPHOLIN-3-ONE Rivaroxaban iMpurity 5 Rivaroxaban Impurity 43 Rivaroxaban Impurity 34
1,2-Cyclohexanedione 4-(4-NITROPHENYL)MORPHOLIN-3-ONE 4-[4-(N-(3-chloro-(2R)-2-hydroxy-1-propyl)aMino)phenyl]Morpholin-3-one (S)-4-(4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one.HCl 5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE
Ethyl (R)-(-)-4-cyano-3-hydroxybutyate 3-MORPHOLINONE, 4-[4-[(5S)-5-(AMINOMETHYL)-2-OXO-3-OXAZOLIDINYL]PHENYL]- 5-Chloro-2-thiophenecarboxylic Acid m-(Trifluoromethyl)phenylacetic acid 2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione
AcetaMide, N-[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]- Rivaroxaban Impurity 38 (S)-(+)-Epichlorohydrin

1of4

(S)-2-OXIRANYLMETHYL-ISOINDOLE-1,3-DIONE (S)-(+)-GLYCIDYL PHTHALIMIDE (S)-GLYCIDYL PHTHALIMIDE 2-[[(2S)-oxiran-2-yl]methyl]isoindole-1,3-dione Rivaroxaban Impurity 39 2-((2S)-OXIRANYLMETHYL)-1H-ISOINDOLE-1,3(2H)-DIONE (S)-(+)-N-(2,3-Epoxypropyl)phthalimide 2-[(2S)-oxiran-2-ylmethyl]-1H-isoindole-1,3(2H)-dione Rivaroxaban Intermediate 2 2-[(2S)-ox 2-[(2S)-2-oxiranyl Methyl]-1H-isoindole-1,3(2H)-dione (2S)-2-(OXIRANYLMETHYL)-1H-ISOINDOLE-1,3(2H)-DIONE (S)-2-OXIRANYLMETHYL-ISOINDOLE-1,3-DIONE (S)-(+)-GLYCIDYL PHTHALIMIDE (S)-GLYCIDYL PHTHALIMIDE 2-((2S)-OXIRANYLMETHYL)-1H-ISOINDOLE-1,3(2H)-DIONE 2-[(2S)-ox 2-[(2S)-2-oxiranyl Methyl]-1H-isoindole-1,3(2H)-dione (S)-4-(oxiran-2-ylMethyl)isoindoline-1,3-dione 1H-Isoindole-1,3(2H)-dione, 2-[(2S)-2-oxiranylMethyl]- N-(S)-Glycidylphthalimide (S)-(+)-N-(2,3-Epoxypropyl)pthalaMide (S)-N-GlycidylphthaliMide, ee: 97.5% (S)-(+)-N-(2,3-Epoxypropyl)phthaliMide >=99.0% (GC) (S)-N-GlycidylphthaliMide, ee: 98% (S)-(+)-GLYCIDYL PHTHALIdime (S)-N-Glycidylphthalimide, 98.5%, ee: 97.5% (S)-N-Glycidylphthalimide, 98.5%, ee: 98% PHTHAL Rivaroxaban Impurity R Linezolid EPP Impurity 2-{[(2S)-oxiran-2-yl]methyl}-2,3-dihydro-1H-isoindole-1,3-dione (S)-(+)-GLYCIDYL PHTHALIMIDEONE (S)-N-Glycidylphthalimide> (S)-(+)-GL S-Glycidyl Phthalamide (S)-(+)-GLYCIDYL PHTHALIMIDE ISO 9001：2015 REACH Rivaroxaban intermediates，(S)-(+)-Glycidyl Phthalimide (S)- (+) - (2,3-Epoxypropyl) phthalimide 2-Amino-8-picoline 2-[[(2S)-oxiran-2-yl]methyl]isoindoline-1,3-dione (S)-N-Glycidylphthalimide, ≥99% (s)-2-oxiranylmethyl-isoindole-1,3-dione/(S)-(+)-Glycidyl Phthalimide (2S)-2-Oxiranylmethyl-isoindole-1,3-dione (S)-2-Oxiranylmethyl-isoindole-1,3-dione (or) (S) (+)- Glycidyl Phthalimide S)-2-(Oxiran-2-ylmethyl)isoindoline-1,3-ion 2-[(2s)-oxirane-2yl methyl]-1H-isoindole-1,3(2H)-dione ( S ) -2- ( Oxiran - 2 - ylmethyl ) -1H - isoindole - 1,3 ( 2H ) dione (S)-Glycidyl Phthalimide or (S)-2-(oxiran-2-ylmethyl)isoindoline-1,3-dione 2-(((S)-Oxiran-2yl)Methyl)Isoindoline-1,3-Dione (S)-2-(oxiran-2-ylmethyl isoindoline-1,3-dione (or) (S)-N-Glycidylphthalimide (S)-N-Glycidylphthalimide, ≥ 98.0% (S)-(+)-N-(2,3-Epoxypropyl)phthalimide or (S)-N-Glycidylphthalimide (S)-N-Glycidylphthalimide, 10 mM in DMSO (S)-(+)-N-(2,3-Epoxypropyl)phthalimide (S)-(+)-N-(2,3-Epooypropyl)pththalimide S(+) -Glycidyl phthamide (S)-N-Glycidylphthalimide 161596-47-0 161592-47-0 61596-47-0 Intermediate of Rivaroxaban