2,4-Dichloro-6,7-dimethoxyquinazoline
- CAS No.
- 27631-29-4
- Chemical Name:
- 2,4-Dichloro-6,7-dimethoxyquinazoline
- Synonyms
- TIMTEC-BB SBB000972;Doxazosin Impurity 6;Doxazosin iMpurity E;Doxazosin EP IMpurity E;7-diMethoxyquinoazoline;Doxazosin Related CoMpound E;Doxazosin Mesilate Impurity E;2,4-Dichloro-6,7-dimethoxyquin;Doxazosin Mesilate EP Impurity E;Doxazosin USP Related Compound E
- CBNumber:
- CB7289392
- Molecular Formula:
- C10H8Cl2N2O2
- Molecular Weight:
- 259.09
- MDL Number:
- MFCD00051733
- MOL File:
- 27631-29-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Doxazosin Related Compound E certified reference material, pharmaceutical secondary standard | PHR3309 | 50mg | $592 |
| 2,4-Dichloro-6,7-dimethoxyquinazoline 97% | 550868 | 25g | $108 |
| Doxazosin Related Compound E United States Pharmacopeia (USP) Reference Standard | 1225474 | 20mg | $1300 |
| 2,4-Dichloro-6,7-dimethoxyquinazoline >98.0%(HPLC)(N) | D3746 | 5g | $188 |
| 2,4-Dichloro-6,7-dimethoxyquinazoline | D434230 | 25g | $175 |
| More product size | |||
| Melting point | 175-178 °C (lit.) |
|---|---|
| Boiling point | 340.5±42.0 °C(Predicted) |
| Density | 1.5369 (rough estimate) |
| refractive index | 1.6100 (estimate) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| pka | -0.49±0.30(Predicted) |
| form | Crystalline Powder |
| color | Pale yellow to beige |
| Water Solubility | Insoluble in water. |
| Sensitive | Moisture Sensitive |
| BRN | 190331 |
| CAS DataBase Reference | 27631-29-4(CAS DataBase Reference) |
| FDA UNII | B6720H065I |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 37/39-26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29334900 | |||||||||
| NFPA 704 |
|
2,4-Dichloro-6,7-dimethoxyquinazoline price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR3309 | Doxazosin Related Compound E certified reference material, pharmaceutical secondary standard | 27631-29-4 | 50mg | $592 | 2025-07-31 | Buy |
| Sigma-Aldrich | 550868 | 2,4-Dichloro-6,7-dimethoxyquinazoline 97% | 27631-29-4 | 25g | $108 | 2025-07-31 | Buy |
| Sigma-Aldrich | 1225474 | Doxazosin Related Compound E United States Pharmacopeia (USP) Reference Standard | 27631-29-4 | 20mg | $1300 | 2025-07-31 | Buy |
| TCI Chemical | D3746 | 2,4-Dichloro-6,7-dimethoxyquinazoline >98.0%(HPLC)(N) | 27631-29-4 | 5g | $188 | 2025-07-31 | Buy |
| TRC | D434230 | 2,4-Dichloro-6,7-dimethoxyquinazoline | 27631-29-4 | 25g | $175 | 2021-12-16 | Buy |
2,4-Dichloro-6,7-dimethoxyquinazoline Chemical Properties,Uses,Production
Chemical Properties
pale yellow to beige crystalline powder
Uses
An intermediate in the preparation of potential inhibitors of epidermal growth factor receptor kinases. An intermediate in the preparation of Terazosin (T105000).
Uses
2,4-Dichloro-6,7-dimethoxyquinazoline is used as an intermediate in the preparation of potential inhibitors of epidermal growth factor receptor kinases. It is also used as an intermediate in the preparation of terazosin.
Synthesis
28888-44-0
27631-29-4
The general procedure for the synthesis of 2,4-dichloro-6,7-dimethoxyquinazoline from 6,7-dimethoxy-2,4-quinazolinedione was as follows: in a 100 mL three-necked flask equipped with a reflux condenser, 6,7-dimethoxy-2,4-quinazolinedione (1.00 g) and phosphorus triclosan (15 mL; 24.77 g; 161.53 mmol) were added, the reaction mixture was refluxed at 100 °C in an oil bath with stirring for 24 hours. Upon completion of the reaction, the reaction solution was cooled to room temperature and the reaction was quenched by slowly pouring it into an ice-water mixture under vigorous stirring. The precipitated solid was collected by vacuum filtration and the crude product was purified by silica gel column chromatography using dichloromethane as eluent.
References
[1] Journal of Medicinal Chemistry, 1986, vol. 29, # 5, p. 627 - 629
[2] European Journal of Medicinal Chemistry, 2014, vol. 71, p. 1 - 14
[3] Patent: WO2004/13091, 2004, A2. Location in patent: Page 34-35
[4] The Journal of organic chemistry, 2002, vol. 67, # 23, p. 8284 - 8286
[5] Journal of the Chemical Society, 1948, p. 1759,1765
2,4-Dichloro-6,7-dimethoxyquinazoline Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29734 | 60 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6369 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29799 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
View Lastest Price from 2,4-Dichloro-6,7-dimethoxyquinazoline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-03-04 | 2,4-Dichloro-6,7-dimethoxyquinazoline
27631-29-4
|
US $1.10 / g | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2019-12-25 | 2,4-Dichloro-6,7-dimethoxyquinazoline
27631-29-4
|
US $1.00 / g | 1g | 99% | 10000KGS | Career Henan Chemical Co |
-
- 2,4-Dichloro-6,7-dimethoxyquinazoline
27631-29-4
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
-
- 2,4-Dichloro-6,7-dimethoxyquinazoline
27631-29-4
- US $1.00 / g
- 99%
- Career Henan Chemical Co
