(5-METHOXYPYRIDIN-2-YL)METHANOL
- CAS No.
- 127978-70-5
- Chemical Name:
- (5-METHOXYPYRIDIN-2-YL)METHANOL
- Synonyms
- KML-64;KML-95;5-Methoxy-2-PyridineMethanol;3-Methoxy-6-pyridinemethanol;(5-Methoxy-2-pyridyl)methanol;5-Methoxy pyridine-2-methanol;2-Pyridinemethanol, 5-methoxy-;(5-METHOXYPYRIDIN-2-YL)METHANOL;(5-Methoxypyridine-2-yl)methanol;5-methoxy-2-hydroxymethylpyridine
- CBNumber:
- CB7300273
- Molecular Formula:
- C7H9NO2
- Molecular Weight:
- 139.15
- MDL Number:
- MFCD08235020
- MOL File:
- 127978-70-5.mol
| Product description | Number | Pack Size | Price |
| (5-Methoxypyridin-2-yl)methanol | M226555 | 500mg | $200 |
| (5-Methoxypyridine-2-yl)methanol ≥97.0% | CS-W006204 | 5g | $300 |
| (5-Methoxypyridine-2-yl)methanol ≥97.0% | CS-W006204 | 1g | $109 |
| (5-Methoxypyridine-2-yl)methanol 95+% | 119057 | 1g | $360 |
| (5-Methoxypyridine-2-yl)methanol ≥97.0% | CS-W006204 | 10g | $529 |
| More product size | |||
| Boiling point | 262℃ |
|---|---|
| Density | 1.155 |
| Flash point | 112℃ |
| storage temp. | Inert atmosphere,Room Temperature |
| pka | 13.22±0.10(Predicted) |
| Appearance | White to light yellow Solid |
| InChI | InChI=1S/C7H9NO2/c1-10-7-3-2-6(5-9)8-4-7/h2-4,9H,5H2,1H3 |
| InChIKey | YSGIZFIQWAPBLG-UHFFFAOYSA-N |
| SMILES | C1(CO)=NC=C(OC)C=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933399990 |
(5-METHOXYPYRIDIN-2-YL)METHANOL price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | M226555 | (5-Methoxypyridin-2-yl)methanol | 127978-70-5 | 500mg | $200 | 2021-12-16 | Buy |
| ChemScene | CS-W006204 | (5-Methoxypyridine-2-yl)methanol ≥97.0% | 127978-70-5 | 5g | $300 | 2021-12-16 | Buy |
| ChemScene | CS-W006204 | (5-Methoxypyridine-2-yl)methanol ≥97.0% | 127978-70-5 | 1g | $109 | 2021-12-16 | Buy |
| Matrix Scientific | 119057 | (5-Methoxypyridine-2-yl)methanol 95+% | 127978-70-5 | 1g | $360 | 2021-12-16 | Buy |
| ChemScene | CS-W006204 | (5-Methoxypyridine-2-yl)methanol ≥97.0% | 127978-70-5 | 10g | $529 | 2021-12-16 | Buy |
(5-METHOXYPYRIDIN-2-YL)METHANOL Chemical Properties,Uses,Production
Uses
(5-Methoxypyridin-2-yl)methanol is used in preparation of substituted pyrrolopyridinones as HPK1 antagonists and uses thereof.
Synthesis
75342-32-4
127978-70-5
Compound 12 (CAS: 75342-32-4, 1.40 g, 7.7 mmol) was used as raw material, which was dissolved in methanol (30 mL) and excess potassium hydroxide was added. The reaction mixture was heated to reflux for 2 hours. After completion of the reaction, the solvent was removed by rotary evaporator under reduced pressure. The residue was extracted by partitioning with dichloromethane (20 mL) and water (20 mL). The organic phase was separated, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give compound 13 (5-methoxypyridine-2-methanol) as a light yellow oil (1.00 g, 93% yield). The product was characterized by 1H NMR (CDCl3): δ 1.82 (s, 1H), 3.87 (s, 3H), 4.70 (s, 2H), 7.18-7.24 (m, 2H), 8.25 (d, 1H, J = 2.8 Hz); GC/MS analysis showed m/z 140 (M++1, 3%), 139 (M+, 44%), 138 ( 100%), 110 (71%).
References
[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 14, p. 3913 - 3924
[2] Patent: US6194437, 2001, B1
[3] Patent: US2006/14945, 2006, A1. Location in patent: Page/Page column 40
[4] Journal of Medicinal Chemistry, 1992, vol. 35, # 3, p. 438 - 450
[5] Patent: WO2007/120729, 2007, A2. Location in patent: Page/Page column 40
(5-METHOXYPYRIDIN-2-YL)METHANOL Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Hangzhou Cyanochem Co., Ltd. | +86 17788583750 | sales@cyanochem.com | CHINA | 281 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29795 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10236 | 58 |
| Shanxi Xuanran Import and Export Trade Co., Ltd. | +8617735180244 | mike_yan@xuanranglobal.com | CHINA | 4017 | 58 |
View Lastest Price from (5-METHOXYPYRIDIN-2-YL)METHANOL manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2020-01-09 | 5-METHOXYPYRIDIN-2-YL)METHANOL
127978-70-5
|
US $5.50 / KG | 1KG | 98%min | 1kg1-100kg | Career Henan Chemical Co |
-
- 5-METHOXYPYRIDIN-2-YL)METHANOL
127978-70-5
- US $5.50 / KG
- 98%min
- Career Henan Chemical Co
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